ChemicalBook >> CAS DataBase List >>L-Glutamic acid dimethyl ester hydrochloride

L-Glutamic acid dimethyl ester hydrochloride

L-Glutamic acid dimethyl ester hydrochloride structure

CAS No.: 23150-65-4

Chemical Name:: L-Glutamic acid dimethyl ester hydrochloride

Synonyms: DIMETHYL L-GLUTAMATE HYDROCHLORIDE;PF-1;L-Glutamic Acid Dimethyl Ester HCl;Glu(Ome)2.Hcl;GLU(OME)-OMEHCL;H-GLU(OME)-OME HCL;L-Glu(OMe)-OMe·HCl;H-L-Glu(Me)-OMe*HCl;L-Glutamic acid dime;DiMethyl-L-GlutaMate

CBNumber:: CB0682345

Molecular Formula:: C7H14ClNO4

Molecular Weight:: 211.64

MDL Number:: MFCD00038879

MOL File:: 23150-65-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:49:10

Request For Quotation

L-Glutamic acid dimethyl ester hydrochloride Properties

Melting point	89-90°C
alpha	26 º (c=5% in H2O)
refractive index	26 ° (C=5, H2O)
storage temp.	2-8°C
solubility	Methanol, Water
form	Powder
color	White
optical activity	[α]20/D +26.0±1°, c = 5% in H2O
Water Solubility	Soluble in water, methanol (50 mg/ml).
Sensitive	Hygroscopic
BRN	4238829
Stability	Hygroscopic
Major Application	peptide synthesis
InChI	InChI=1/C7H13NO4.ClH/c1-11-6(9)4-3-5(8)7(10)12-2;/h5H,3-4,8H2,1-2H3;1H/t5-;/s3
InChIKey	MFUPLHQOVIUESQ-JEDNCBNOSA-N
SMILES	[C@@H](N)(C(=O)OC)CCC(=O)OC.Cl \|&1:0,r\|
CAS DataBase Reference	23150-65-4(CAS DataBase Reference)
FDA UNII	185VC5X3PF
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H319

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

29224999

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		1

L-Glutamic acid dimethyl ester hydrochloride price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	49560	L-Glutamic acid dimethyl ester hydrochloride ≥99.0% (dried material, AT)	23150-65-4	10g	$101	2026-04-30	Buy
Sigma-Aldrich	49560	L-Glutamic acid dimethyl ester hydrochloride ≥99.0% (dried material, AT)	23150-65-4	50g	$323	2026-04-30	Buy
TCI Chemical	D3353	Dimethyl L-Glutamate Hydrochloride >98.0%(N)(T)	23150-65-4	5g	$41	2026-04-30	Buy
TCI Chemical	D3353	Dimethyl L-Glutamate Hydrochloride >98.0%(N)(T)	23150-65-4	25g	$160	2026-04-30	Buy
Usbiological	278438	L-Glutamic acid dimethyl ester hydrochloride	23150-65-4	50g	$350	2026-06-03	Buy

Product number	Packaging	Price	Buy
49560	10g	$101	Buy
49560	50g	$323	Buy
D3353	5g	$41	Buy
D3353	25g	$160	Buy
278438	50g	$350	Buy

L-Glutamic acid dimethyl ester hydrochloride Chemical Properties, Uses, Production

Chemical Properties

Crystalline

Uses

L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate.

Uses

L-Glutamic acid dimethyl ester hydrochloride is used as a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-86-0

L-Glutamic acid dimethyl ester hydrochloride

23150-65-4

To a 500 mL four-necked flask equipped with a stirrer, thermometer and reflux condenser (connected to a 30% aqueous sodium hydroxide solution absorption unit), 300 g of methanol, 14.7 g (0.10 mol) of L-glutamic acid, and 30.0 g (0.25 mol) of thionyl chloride were added sequentially. The reaction mixture was heated to 60-63 °C and the reaction was stirred at this temperature for 7 hours. Upon completion of the reaction, the system was cooled to 20-25 °C, followed by the passage of nitrogen to displace the hydrogen chloride gas in the system for 30 min. Next, the excess thionyl chloride and methanol were recovered by distillation. To the residue, 100 g of methyl tert-butyl ether was added and pulped, followed by filtration to collect the solid. Upon drying, 20.8 g of L-glutamic acid dimethyl ester hydrochloride was obtained as a white solid. The product was analyzed by high performance liquid chromatography (HPLC) with 99.5% purity and 98.1% yield.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 24, p. 6144 - 6153
[2] Archiv der Pharmazie, 2005, vol. 338, # 5-6, p. 281 - 290
[3] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 18, p. 6273 - 6290
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 777 - 793
[5] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0053; 0054

L-Glutamic acid dimethyl ester hydrochloride synthesis

Synthesis of L-Glutamic acid dimethyl ester hydrochloride from Methanol and L-Glutamic acid

L-Glutamic acid dimethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

L-(+)-Glutamic acid hydrochloride L-Glutamic acid 5-methyl ester Methanol 2,2-Dimethoxypropane DL-Glutamic acid

L-Glutamic acid Chlorotrimethylsilane

1of2

Preparation Products

3-N-Boc-Aminomethylpiperidine 1H-Indole, 5-methoxy-2,4-dimethyl- 5-methyl L-2-aminoglutarate hydrochloride

L-Glutamic acid dimethyl ester hydrochloride Suppliers

Global Suppliers ( 392)

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Xiaqing Technological Co., Ltd.	519-519-88783621 13906127738	xjq@xialichem.com	China	143	70
NINGBO INNO PHARMCHEM CO.,LTD.	15558396803	sales@nbinno.com	China	135	58
Hubei Hengluyuan Technology co.ltd	027-88188016 18717196322	1764683941@qq.com	China	5944	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64

Supplier	Advantage
Changzhou Xiaqing Technological Co., Ltd.	70
NINGBO INNO PHARMCHEM CO.,LTD.	58
Hubei Hengluyuan Technology co.ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64

View Latest Price from L-Glutamic acid dimethyl ester hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	H-L-Glu(OMe)-OMe.HCl 23150-65-4	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-11	L-Glutamic acid dimethyl ester hydrochloride 23150-65-4	1KG	98.0%	1000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-04-04	L-Glutamic acid dimethyl ester hydrochloride 23150-65-4	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

H-L-Glu(OMe)-OMe.HCl
23150-65-4
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

L-Glutamic acid dimethyl ester hydrochloride
23150-65-4
$0.00
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

L-Glutamic acid dimethyl ester hydrochloride
23150-65-4
98%
Henan Aochuang Chemical Co.,Ltd.

L-Glutamic acid dimethyl ester hydrochloride Spectrum

L-Glutamic acid dimethyl ester hydrochloride(23150-65-4)¹HNMR

23150-65-4 (L-Glutamic acid dimethyl ester hydrochloride) Related Search:

Topotecan hydrochloride Dimethyl sulfate Dimethyl phosphite Dimethyl phthalate Dimethyl ether

Dimethyl fumarate Dimethyl adipate Dacthal Dimethyl oxalate L-Glutamic acid

L-(+)-Glutamic acid hydrochloride Dimethyl carbonate L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride L-Glutamic acid di-tert-butyl ester hydrochloride Dimethyl sulfoxide

N,N-Dimethylformamide Ethane Diethyl L-glutamate hydrochloride

1of4

H-GLU(OME)-OME HCL GLUTAMIC ACID(OME)-OME HCL Dimethyl L-glutamate hydrochloride~H-Glu(OMe)-OMe.HCl dimethyl L-2-aminoglutarate hydrochloride L-GUTAMINSAURE-DIMETHYLESTER HYDROCHLORIDE DimethylL-glutamateHCl~H-Glu(OMe)-OMe.HCl GLU(OME)-OMEHCL H-L-Glu(Me)-OMe*HCl L-Glutamic acid di-methy ester hydrochloride L-GLUTAMIC ACID-A,Y-DIMETHYLESTER HYDROCHLORIDE dimethyl-L-glutamate HCl L-Glutamic acid dimethyl ester hydrochloride, 98+% Glu(Ome)2.Hcl H-Glu-(OMe)-OMe hydrochloride L-Glutamic acid dimethyl ester hydrochloride ,99% L-Glutamic acid dime DiMethyl-L-GlutaMate (S)-DiMethyl 2-aMinopentanedioate hydrochloride L-Glutamic Acid Dimethyl Ester Hydrochloride H-Glu(OMe)-OMe.HCl L-GlutaMic acid diMethyl ester hydrochloride, 99%, pure diMethyl (2S)-2-aMinopentanedioate hydrochloride L-GlutaMic acid diMethyl ester hydrochlorid L-GlutaMic acid diMethyl es L-GlutaMic acid diMethyl ester hydrochloride >=99.0% (dried Material, AT) DiMethyl L-GlutaMate Hydrochloride , 98.0%(N&T L-Glu(OMe)-OMe·HCl L-Glutamic acid dimethyl ester hydrochloride≥ 98% (HPLC) L-Glutamic acid dimethyleester hydrochloride (S)-DIMETHYL 2-AMINOPENTANEDIOATE HCL Glutamic acid dimethyl ester hydrochloride DIMETHYL L-GLUTAMATE HYDROCHLORIDE L-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE L-GLUTAMIC ACID-ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE L-GLUTAMIC ACID ALPHA,GAMMA-DIMETHYL ESTER HYDROCHLORIDE SALT DimethylL-GlutamateHydrochloride> L-Glutamic acid, 1,5-dimethyl ester, hydrochloride (1:1) imethyl(2S)-2-aminopentanedioate,hydrochloride L-GLUTAMIC ACID DIMETHYL ESTER HYDROCHLORIDE 23150-65-4 L-Glutamic acid dimethyl ester hydrochloride USP/EP/BP H-L-Glu(OMe)-OMe.HCl L-glutamic dimethyl ester hydrochloride L-Glutaic Acid dimethyl ester.HCL Arginine Impurity(Hydrochloride) L-Glutamic acid dimethyl ester hydrochloride L-Glutamic Acid Dimethyl Ester HCl PF-1 23150-65-4 C9H17NO4HCl C9H18NO4Cl CH3OCOCH2CH2CHNH2COOCH3HCl C7H14NO4Cl Specialty Synthesis Peptide Synthesis Amino Acid Derivatives AMINE Amino Acid Methyl Esters Protected & Labeled Amino Acids Amino Acids (C-Protected)