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3-N-Boc-Aminomethylpiperidine

3-N-Boc-Aminomethylpiperidine Structure
3-N-Boc-Aminomethylpiperidine structure
CAS No.
142643-29-6
Chemical Name:
3-N-Boc-Aminomethylpiperidine
Synonyms
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE;PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;3-BOC-AMINOPIPERIDINE;3-BOC-3-AMINOPIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE;3-N-BOC-AMINOMETHYL PIPERIDINE;3-BOC-AMINOMETHYL PIPERIDINE 98%;(±)-3-(Boc-aminomethyl)piperidine;3-AMINOPIPERIDINE, 3-BOC PROTECTED;(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
CBNumber:
CB5205644
Molecular Formula:
C11H22N2O2
Molecular Weight:
214.31
MDL Number:
MFCD01632454
MOL File:
142643-29-6.mol
MSDS File:
SDS
Last updated:2026-05-28 01:16:45
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3-N-Boc-Aminomethylpiperidine Properties

Melting point 60-70 °C(lit.)
Boiling point 321.8±15.0 °C(Predicted)
Density 0.981
storage temp. 2-8°C
pka 12.71±0.46(Predicted)
form solid
color White
BRN 7023643
InChI 1S/C11H22N2O2/c1-11(2,3)15-10(14)13-8-9-5-4-6-12-7-9/h9,12H,4-8H2,1-3H3,(H,13,14)
InChIKey KHPQHXGYYXYTDN-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)NCC1CCCNC1
CAS DataBase Reference 142643-29-6(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C,Xi
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3259 8/PG 2
WGK Germany  3
Hazard Note  Irritant
HazardClass  8
HS Code  29333990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
NFPA 704
0
3 0

3-N-Boc-Aminomethylpiperidine price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 653896 3-(Boc-aminomethyl)piperidine 95% 142643-29-6 1g $95 2023-06-20 Buy
AstaTech B56684 3-N-BOC-AMINOMETHYL PIPERIDINE 98% 142643-29-6 1G $43 2026-04-30 Buy
AstaTech B56684 3-N-BOC-AMINOMETHYL PIPERIDINE 98% 142643-29-6 5G $89 2026-04-30 Buy
AstaTech B56684 3-N-BOC-AMINOMETHYL PIPERIDINE 98% 142643-29-6 25G $206 2026-04-30 Buy
Apolloscientific OR5910 3-(Aminomethyl)piperidine, 3-BOC protected 95% 142643-29-6 1g $21 2026-06-04 Buy
Product number Packaging Price Buy
653896 1g $95 Buy
B56684 1G $43 Buy
B56684 5G $89 Buy
B56684 25G $206 Buy
OR5910 1g $21 Buy

3-N-Boc-Aminomethylpiperidine Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

Reagent for:

  • Preparation of 9-substituted phenanthrene-based tylophorine analogs
  • Enzymatic acylation

Uses

Reagent for:
Preparation of Tylophorine analogs
Enzymatic acylation

Synthesis

tert-butyl ((1-benzylpiperidin-3-yl)methyl)carbamate

220031-61-8

3-N-Boc-Aminomethylpiperidine

142643-29-6

To a solution of tert-butyl (1-benzylpiperidin-3-yl)methylcarbamate (2.05 g, 6.74 mmol, 1.0 equiv) in methanol (40 mL) was added 10% Pd(OH)2/C (0.21 g, 10 wt%). Cyclohexene (6.80 mL, 67.40 mmol, 10.0 eq.) was added to the reaction system under argon protection. The resulting suspension was refluxed under argon atmosphere for 20 hours. Upon completion of the reaction, it was filtered through a Celite pad (Celite 577 fine) and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of dichloromethane/methanol/triethylamine (3:1:0.1, v/v/v) to afford 1.31 g of the target compound 3-Boc-aminomethylpiperidine as a colorless viscous oil. Yield: 91%; Thin Layer Chromatography Rf = 0.33 (dichloromethane/methanol/triethylamine = 3:1:0.1); 1H NMR (400 MHz, CDCl3) δ: 1.08 (qd, J = 11.2, 4.0 Hz, 1H, CH2CHAHBCH), 1.42 (s, 9H, 3 x CH3), 1.45-1.52 (m, 1H. CHAHBCH2CH), 1.58-1.70 (m, 2H, CHAHBCHAHBCH), 1.76-1.82 (m, 1H, CH), 2.32 (t, J = 11.2 Hz, 1H, NHCHAHBCH), 2.52-2.60 (m, 2H, CH2CHAHBNH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCOHBCH), 2.97-3.03 (m, 3H, CH2NHCO 3H, CH2NHCO + CH2CHAHBNH), 3.06 (dd, J = 11.6, 3.2 Hz, 1H, NHCHAHBCH), 4.63 (br s, 1H, NHCO); 13C NMR (100 MHz, CDCl3) δ: 24.99, 27.97, 28.27, 36.86, 43.74, 45.90, 49.54, 78.28, 155.86; ESI-HRMS m/z calculated C11H23N2O2 [M+H]+ 215.1760, measured 215.1763; IR (KBr) υ: 3385, 2978, 2934, 1685, 1528, 1458, 1367, 1272, 1254, 1174, 1009 cm-1 1174, 1009 cm-1.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4442 - 4452
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 633 - 645
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139

3-N-Boc-Aminomethylpiperidine synthesis

220031-61-8
142643-29-6
Synthesis of 3-N-Boc-Aminomethylpiperidine from tert-butyl ((1-benzylpiperidin-3-yl)methyl)carbamate

3-N-Boc-Aminomethylpiperidine Preparation Products And Raw materials

Raw materials

L-Glutamic acid dimethyl ester hydrochloride acetonitrile Hexane Ammonium hydroxide Ethanol
Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate Sodium borohydride Triethylamine
Methanesulfonyl chloride 1,4-Dioxane Ethyl acetate Sodium bicarbonate Dichloromethane
Magnesium sulfate Citric acid tert-butyl ((1-benzylpiperidin-3-yl)methyl)carbamate

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Preparation Products

3-N-Boc-Aminomethylpiperidine Suppliers

Global Suppliers ( 166)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
Chembest Research Laboratories Limited 61
Alfa Aesar 84
ForeChem (Nantong) Technology Co.,Ltd. 61
Capot Chemical Co., Ltd 66
Sichuan Guanghan Bio-Tech Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60

View Latest Price from 3-N-Boc-Aminomethylpiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-N-Boc-Aminomethylpiperidine pictures 2025-04-04 3-N-Boc-Aminomethylpiperidine
142643-29-6
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
3-N-Boc-Aminomethylpiperidine pictures 2019-07-06 3-N-Boc-Aminomethylpiperidine
142643-29-6
 $1.00 1KG 95% 500KG Career Henan Chemical Co

3-N-Boc-Aminomethylpiperidine Spectrum

3-N-Boc-Aminomethylpiperidine(142643-29-6)1HNMR

142643-29-6 (3-N-Boc-Aminomethylpiperidine) Related Search:

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2-Piperidylmethylamine Trimethylphosphine oxide 2-Boc-aminomethylpyrrolidine

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3-N-BOC-AMINOMETHYL PIPERIDINE 1,1-diMethylethyl [(piperidin-3-yl)-Methyl]carbaMate tert-Butyl [(piperidin-3-yl)methyl]carbamate, 3-{[(tert-Butoxycarbonyl)amino]methyl}piperidine (3-Piperidinylmethyl)-carbamic acid 1,1-dimethylethyl ester Carbamic acid, N-(3-piperidinylmethyl)-, 1,1-dimethylethyl ester (+/-)-3-(Boc-aminomethyl)piperidine >=98.0% (TLC) tert-butyl N-(piperidin-3-ylmethyl)carbamate 3-AMINOPIPERIDINE, 3-BOC PROTECTED (3-AMINOMETHYL, N-BOC PROTECTED)PIPERIDINE (+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE 3-BOC-AMINOMETHYL PIPERIDINE 3-BOC-AMINOPIPERIDINE TERT-BUTYL (PIPERIDIN-3-YLMETHYL) CARBAMATE TERT-BUTYL N-(3-PIPERIDYLMETHYL)CARBAMATE (S)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER (R,S)-(BOC-3-AMINOMETHYL)-PIPERIDINE (R)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER 3-Aminopiperidine, 3-BOC protected 97% 3-BOC-3-AMINOPIPERIDINE 3-BOC-AMINOMETHYL PIPERIDINE 98% (Piperidin-3-ylmethyl) carbamic acid tert-butyl ester, tert-Butyl (piperidin-3-ylmethyl) carbamate 3-(Aminomethyl)piperidine, 3-BOC protected tert-butyl (piperidin-3-ylmethyl)carbamate(SALTDATA: FREE) (R,S)-3-(Boc-aminomethyl)-piperidine N-[(3S)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER Carbamic acid, (3-piperidinylmethyl)-, 1,1-dimethylethyl ester (^+)-3-(Boc-aminomethyl)piperidine,98% (±)-3-(Boc-aminomethyl)piperidine (±)-3-(Boc-aminomethyl)piperidine, CAS 142643-29-6 3-(Boc-aminomethyl)piperidine - [A12322] TERT-BUTYL PIPERIDIN-3-YLCARBAMATE 142643-29-6 142643-23-6 C5H10NCH2NHCO2C4H9 Piperidines Heterocyclic Building Blocks Building Blocks pharmacetical Amines Pyrans, Piperidines &Piperazines Piperidine API intermediates Pyrans, Piperidines & Piperazines