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ChemicalBook >> CAS DataBase List >>2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Structure
2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid structure
CAS No.
40003-41-6
Chemical Name:
2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid
Synonyms
IFLAB-BB F2124-0223;2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC A&;2-BroMo-4-Methyl-5-thiazolecarboxylic acid;2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID;2-Bromo-4-Methyl Thiazole-4-Carboxylic Acid;5-Thiazolecarboxylic acid, 2-bromo-4-methyl-;2-Bromo-4-methylthiazole-5-carboxylic acid 96%;2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid;JR-13563, 2-Bromo-4-methylthiazole-5-carboxylic acid, 97%
CBNumber:
CB0685184
Molecular Formula:
C5H4BrNO2S
Molecular Weight:
222.06
MDL Number:
MFCD03822128
MOL File:
40003-41-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:27
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2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Properties

Melting point 158 °C (dec.)
Boiling point 349.5±22.0 °C(Predicted)
Density 1.895±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
form powder to crystal
pka 2.16±0.37(Predicted)
color White to Light yellow to Light orange
InChI 1S/C5H4BrNO2S/c1-2-3(4(8)9)10-5(6)7-2/h1H3,(H,8,9)
InChIKey HMSQZHBSTZZNGI-UHFFFAOYSA-N
SMILES Cc1nc(Br)sc1C(O)=O
CAS DataBase Reference 40003-41-6
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P280
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
WGK Germany  3
HS Code  2934100090
Storage Class 11 - Combustible Solids
Hazard Classifications Skin Sens. 1

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 646008 2-Bromo-4-methylthiazole-5-carboxylic acid 96% 40003-41-6 1g $79.8 2023-06-20 Buy
Sigma-Aldrich 646008 2-Bromo-4-methylthiazole-5-carboxylic acid 96% 40003-41-6 5g $308 2023-06-20 Buy
TCI Chemical B5336 2-Bromo-4-methylthiazole-5-carboxylic Acid >98.0%(T) 40003-41-6 1g $101 2026-04-30 Buy
Usbiological 159427 2-Bromo-4-methyl-5-thiazolecarboxylic Acid 40003-41-6 2.5g $531 2026-06-03 Buy
Apolloscientific OR450004 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid >98% 40003-41-6 5g $21 2026-06-04 Buy
Product number Packaging Price Buy
646008 1g $79.8 Buy
646008 5g $308 Buy
B5336 1g $101 Buy
159427 2.5g $531 Buy
OR450004 5g $21 Buy

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Chemical Properties, Uses, Production

Uses

2-Bromo-4-methyl-5-thiazolecarboxylic Acid, is a heterocyclic building block used for the preparation of various chemicals. It is used in the synthesis of new azole Antifungals.

Synthesis

ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

22900-83-0

2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID

40003-41-6

General procedure for the synthesis of 2-bromo-4-methylthiazole-5-carboxylic acid from ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate: 5N aqueous NaOH solution (15 mL) was added to a solution of ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (1 mmol) in ethanol (20 mL), and the reaction mixture was stirred for 14 h at room temperature. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled and neutralized with concentrated hydrochloric acid. The organic layer was extracted with ethyl acetate (EtOAc) and the organic phase was dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by column chromatography using silica gel (60-120 mesh) as stationary phase and gradient elution with a mixed solvent of ethyl acetate and petroleum ether, which ultimately afforded 2-bromo-4-methylthiazole-5-carboxylic acid as an off-white solid in 76% yield. The structure of the product was confirmed by 1H NMR (CDCl3, δ: 13.19, s, 1H; 2.54, s, 3H) and mass spectrometry (ESI-MS, m/z: 223 [M+H]+).

References

[1] Patent: EP2604268, 2015, B1. Location in patent: Paragraph 0150-0151
[2] Russian Journal of General Chemistry, 2016, vol. 86, # 7, p. 1722 - 1729
[3] Zh. Obshch. Khim., 2016, vol. 86, # 7, p. 1722 - 1729,8
[4] Justus Liebigs Annalen der Chemie, 1890, vol. 259, p. 298
[5] Roczniki Chemii, 1972, vol. 46, p. 1647 - 1658

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid synthesis

67899-00-7
40003-41-6
Synthesis of 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid from 2-Amino-4-methylthiazole-5-carboxylic acid

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

2-Amino-4-methylthiazole-5-carboxylic acid Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate Ethyl 2-amino-4-methylthiazole-5-carboxylate Sodium hydroxide Water
Ethanol

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Preparation Products

2-Bromo-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide 2-Bromo-N-(3,4-difluorobenzyl)-4-methylthiazole-5-carboxamide

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Suppliers

Global Suppliers ( 121)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
skychemical Co.Ltd 021-20958197 20965099 sales@skychemical.com China 1182 57
Shanghai Xiannuo Biotechnology Co., Ltd. 021-50718719 13918719472 China 978 58
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62
skychemical Co.Ltd 57
Shanghai Xiannuo Biotechnology Co., Ltd. 58
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Thermo Fisher Scientific 75
Shanghai T&W Pharmaceutical Co., Ltd. 58

View Latest Price from 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IFLAB-BB F2124-0223 pictures 2026-08-07 IFLAB-BB F2124-0223
40003-41-6
 $1.00-1.50 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd
2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID pictures 2020-02-17 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
40003-41-6
 $7.00 1KG 99% 100KG Career Henan Chemical Co

2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid Spectrum

2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID(40003-41-6)1HNMR

40003-41-6 (2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid) Related Search:

Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate 2-Bromo-4-(trifluoromethyl)thiazole-5-carboxylic acid ethyl ester 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid 2-Bromo-4-methylthiazole 4-Methylthiazole
4-Methylthiazole-5-carboxylic acid 5-Thiazolecarboxylicacid,2-bromo-4-methyl-,methylester(9CI) 2-Bromo-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid 5-Thiazolecarboxylicacid,2-bromo-4-(1,1-dimethylethyl)-,ethylester(9CI)

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IFLAB-BB F2124-0223 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID 2-BROMO-4-METHYLTHIAZOLE-5-CARBOXYLIC A& 2-BroMo-4-Methyl-5-thiazolecarboxylic acid 2-Bromo-4-methylthiazole-5-carboxylic acid 96% 5-Thiazolecarboxylic acid, 2-bromo-4-methyl- JR-13563, 2-Bromo-4-methylthiazole-5-carboxylic acid, 97% 2-Bromo-4-Methyl Thiazole-4-Carboxylic Acid 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid 40003-41-6 Thiazoles Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Thiazoles ThiazolesHeterocyclic Building Blocks Building Blocks