5-NITROTHIOPHENE-2-CARBOXALDEHYDE
- CAS No.
- 4521-33-9
- Chemical Name:
- 5-NITROTHIOPHENE-2-CARBOXALDEHYDE
- Synonyms
- 5-NITROTHIOPHENE-2-CARBALDEHYDE;5-NITRO-2-THIOPHENECARBOXALDEHYDE;AKOS 93853;5-Nitrothiophene-2-c;LABOTEST-BB LT00112375;Mefloquineb Impurity 8;5-Nitrothiophen-2-carbaldehyd;5-NITRO-2-THIOPHENECARBALDEHYDE;5-Nitro-2-thiophennecarbaldehyde;5-NITROTHIOPHENE-2-CARBOXALDEHYDE
- CBNumber:
- CB0686631
- Molecular Formula:
- C5H3NO3S
- Molecular Weight:
- 157.15
- MDL Number:
- MFCD00005433
- MOL File:
- 4521-33-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Nitro-2-thiophenecarboxaldehyde 98% | 302295 | 5g | $122 |
| 5-Nitro-2-thiophenecarboxaldehyde 98% | 302295 | 25g | $512 |
| 5-Nitrothiophene-2-carboxaldehyde | TRC-N565510-5G | 5g | $91 |
| 5-Nitrothiophene-2-carboxaldehyde | TRC-N565510-1G | 1g | $59 |
| 5-Nitrothiophene-2-carboxaldehyde | TRC-N565510-10G | 10g | $140 |
| More product size | |||
| Melting point | 75-77 °C (lit.) |
|---|---|
| Boiling point | 118-120 °C(Press: 3-4 Torr) |
| Density | 1.534±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | acetone: soluble1%, clear, yellow |
| form | Solid |
| color | Brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 120540 |
| InChI | InChI=1S/C5H3NO3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3H |
| InChIKey | CHTSWZNXEKOLPM-UHFFFAOYSA-N |
| SMILES | C1(C=O)SC([N+]([O-])=O)=CC=1 |
| CAS DataBase Reference | 4521-33-9(CAS DataBase Reference) |
| FDA UNII | NB6CXG7SPH |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-NITROTHIOPHENE-2-CARBOXALDEHYDE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 302295 | 5-Nitro-2-thiophenecarboxaldehyde 98% | 4521-33-9 | 5g | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | 302295 | 5-Nitro-2-thiophenecarboxaldehyde 98% | 4521-33-9 | 25g | $512 | 2023-06-20 | Buy |
| TRC | TRC-N565510-5G | 5-Nitrothiophene-2-carboxaldehyde | 4521-33-9 | 5g | $91 | 2026-06-03 | Buy |
| TRC | TRC-N565510-1G | 5-Nitrothiophene-2-carboxaldehyde | 4521-33-9 | 1g | $59 | 2026-06-03 | Buy |
| TRC | TRC-N565510-10G | 5-Nitrothiophene-2-carboxaldehyde | 4521-33-9 | 10g | $140 | 2026-06-03 | Buy |
5-NITROTHIOPHENE-2-CARBOXALDEHYDE Chemical Properties,Uses,Production
Uses
5-Nitrothiophene-2-carboxaldehyde is a reagent that is used in the activity of mefloquine-oxazolidine derivatives against multidrug-resistant Mycobacterium tuberculosis.
Uses
5-Nitro-2-thiophenecarboxaldehyde was used in preparation of 2, 3-dihydro-2-(5-nitro-2-thienyl) quinazolin-4-(1H)-ones and various novel oxime ether derivatives, anti-protozoan agents.
General Description
Diastereoselectivity in [4+2] cycloaddition of 1-methoxy-2-methyl-3-(trimethylsiloxy)-1,3-pentadiene with 5-nitro-2-thiophenecarboxaldehyde was investigated.
Synthesis
98-03-3
4521-33-9
57500-53-5
General procedure for the synthesis of 5-nitrothiophene-2-carbaldehyde and 4-nitrothiophene-2-carbaldehyde from 2-thiophenecarboxaldehyde: Step 1: Synthesis of 4-nitrothiophene-2-carbaldehyde (1) Fuming nitric acid (40 mL) was mixed with concentrated sulfuric acid (31 mL) and slowly added to a cooled solution of thiophene-2-carbaldehyde (20 g, 17.8 mmol) in concentrated sulfuric acid (4 mL). The reaction was carried out in an ice-salt bath and stirring was continued for 5 min after addition. Subsequently, the reaction was quenched by the addition of ice water and the mixture was extracted with ether. The combined ether extracts were washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a brown oily crude product. 1H NMR analysis of the crude product showed a mixture of 4-nitrothiophene-2-carboxaldehyde and 5-nitrothiophene-2-carboxaldehyde in the ratio of about 40:60. Separation of the mixture by column chromatography (eluent: 30-50% dichloromethane/hexanes) gave 4-nitrothiophene-2-carboxaldehyde in 40% yield as a light yellow solid.1H NMR (CDCl3) δ (ppm). 9.95 (s, 1H), 8.63 (s, 1H), 8.27 (s, 1H).
References
[1] Journal of Chemical Research, Miniprint, 1997, # 9, p. 2001 - 2013
[2] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 46
[3] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 1, p. 162 - 165
[4] Bulletin de la Societe Chimique de France, 1963, p. 479 - 484
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 1378
5-NITROTHIOPHENE-2-CARBOXALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Qiangshan New Material Co.,Ltd. | +86-13951653990 | jjx35259720@hotmail.com | China | 27 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3999 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +86-15689548120 | linda@zhongda-biotech.com | China | 184 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5742 | 58 |
View Lastest Price from 5-NITROTHIOPHENE-2-CARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 5-NITROTHIOPHENE-2-CARBOXALDEHYDE
4521-33-9
|
$11.00-25.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-10-23 | 5-NITROTHIOPHENE-2-CARBOXALDEHYDE
4521-33-9
|
$8.50-151.00 | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2023-11-09 | 2-Thiophenecarboxaldehyde,5-nitro-
4521-33-9
|
$200.00 | 1g | 98% | 10tons | qingdao future trading Co., Ltd |
-
- 5-NITROTHIOPHENE-2-CARBOXALDEHYDE
4521-33-9
- $11.00-25.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-NITROTHIOPHENE-2-CARBOXALDEHYDE
4521-33-9
- $8.50-151.00
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
-
- 2-Thiophenecarboxaldehyde,5-nitro-
4521-33-9
- $200.00
- 98%
- qingdao future trading Co., Ltd
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