5-Nitrothiophene-2-carboxylic acid
- CAS No.
- 6317-37-9
- Chemical Name:
- 5-Nitrothiophene-2-carboxylic acid
- Synonyms
- BUTTPARK 121\04-13;5 - nitro-thiophene;RARECHEM AL BO 0544;5-Nitro-2-thenoic acid;2-Carboxy-5-nitrothiophe;2-Carboxy-5-nitrothiophene;5-nitro-2-thiophenecarboxylic;5-Nitro-2-ThiphenecarboxylicAcid;5-Nitrothiophene-2-carboxylicaci;5-Nitro-2thiaphene-carboxylic acid
- CBNumber:
- CB2197443
- Molecular Formula:
- C5H3NO4S
- Molecular Weight:
- 173.15
- MDL Number:
- MFCD00159552
- MOL File:
- 6317-37-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Nitro-2-thiophenecarboxylic Acid >97.0%(GC)(T) | N0940 | 5g | $67 |
| 5-Nitro-2-thiophenecarboxylic Acid >97.0%(GC)(T) | N0940 | 25g | $265 |
| 5-Nitrothiophene-2-carboxylic acid Asreported | 285400 | 25g | $375 |
| 5-Nitrothiophene-2-carboxylic acid Asreported | 285400 | 50g | $531 |
| 5-Nitrothiophene-2-carboxylic acid Asreported | 285400 | 100g | $744 |
| More product size | |||
| Melting point | 154-159℃ |
|---|---|
| Boiling point | 367.2±27.0 °C(Predicted) |
| Density | 1.676±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 2.69±0.10(Predicted) |
| form | Solid |
| color | Pale yellow |
| InChIKey | UNEPVPOHGXLUIR-UHFFFAOYSA-N |
| CAS DataBase Reference | 6317-37-9(CAS DataBase Reference) |
| FDA UNII | JL3FTQ5YCK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
5-Nitrothiophene-2-carboxylic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | N0940 | 5-Nitro-2-thiophenecarboxylic Acid >97.0%(GC)(T) | 6317-37-9 | 5g | $67 | 2026-04-30 | Buy |
| TCI Chemical | N0940 | 5-Nitro-2-thiophenecarboxylic Acid >97.0%(GC)(T) | 6317-37-9 | 25g | $265 | 2026-04-30 | Buy |
| Usbiological | 285400 | 5-Nitrothiophene-2-carboxylic acid Asreported | 6317-37-9 | 25g | $375 | 2026-06-03 | Buy |
| Usbiological | 285400 | 5-Nitrothiophene-2-carboxylic acid Asreported | 6317-37-9 | 50g | $531 | 2026-06-03 | Buy |
| Usbiological | 285400 | 5-Nitrothiophene-2-carboxylic acid Asreported | 6317-37-9 | 100g | $744 | 2026-06-03 | Buy |
5-Nitrothiophene-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
Solid
Uses
5-Nitrothiophene-2-carboxylic Acid is a reagent used in the preparation of benzothiophene amides which fuctions as nicotinamide ribosyltransferase inhibitors with potential antitumor and anticancer activities. It also functions as an intermediate in varying organic transformations.
Synthesis Reference(s)
Canadian Journal of Chemistry, 44, p. 2881, 1966 DOI: 10.1139/v66-428
Journal of Medicinal Chemistry, 34, p. 2112, 1991
Synthesis
4521-33-9
6317-37-9
General procedure for the synthesis of 5-nitrothiophene-2-carboxylic acid from 5-nitrothiophene-2-carboxaldehyde: 5-nitrothiophene-2-carboxaldehyde (1.685 g, 10.72 mmol) was dissolved in dioxane (30 mL) with sulfamic acid (1.249 g, 12.87 mmol) and cooled down to 0 °C. Subsequently, an aqueous solution of sodium chlorite (1.940 g, 21.44 mmol) was added slowly and dropwise (14 mL). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. A second batch of 5-nitrothiophene-2-carbaldehyde (1.966 g, 12.51 mmol) was treated at the same molar ratio under the same conditions. The two reaction mixtures were combined and extracted by partitioning with ethyl acetate and water. The organic phase was extracted twice with 5% NaHCO3 solution and discarded. The basic aqueous phase was adjusted to pH=2 with 2N HCl and extracted twice with ethyl acetate. The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 5-nitrothiophene-2-carboxylic acid (Int.53) (3.6 g, 20.79 mmol, MS/ESI+ 173.9 [MH]+).
References
[1] Patent: US4220793, 1980, A
[2] Patent: WO2004/18480, 2004, A1. Location in patent: Page 155
[3] Helvetica Chimica Acta, 2002, vol. 85, # 12, p. 4485 - 4517
5-Nitrothiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8927 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29094 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15050 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | sale03@alfachem.cn | China | 9858 | 58 |
View Lastest Price from 5-Nitrothiophene-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Nitrothiophene-2-carboxylic acid
6317-37-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2024-11-26 | 5-Nitrothiophene-2-carboxylic acid
6317-37-9
|
1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
 |
2022-03-11 | 5-nitrothiophene-2-carboxylic acid
6317-37-9
|
$750.00 | 1kg | 98% | 200kg | Nanjing Qiangshan New Material Co.,Ltd. |
-
- 5-Nitrothiophene-2-carboxylic acid
6317-37-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Nitrothiophene-2-carboxylic acid
6317-37-9
- 98%
- Nanjing Fred Technology Co., Ltd
-
- 5-nitrothiophene-2-carboxylic acid
6317-37-9
- $750.00
- 98%
- Nanjing Qiangshan New Material Co.,Ltd.
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