Delta12-prostaglandin J2
- CAS No.
- 87893-54-7
- Chemical Name:
- Delta12-prostaglandin J2
- Synonyms
- C05958;Δ12-PGJ2;DELTA12-PGJ2;12-PROSTAGLANDIN J2;Δ12-Prostaglandin J2;Delta12-prostaglandin J2;TUXFWOHFPFBNEJ-GJGHEGAFSA-N;Δ12-PGJ2 (Δ12-Prostaglandin J2);Δ12-PGJ2 (Δ12-Prostaglandin J2);Delta12-PGJ2 (Delta12-Prostaglandin J2)
- CBNumber:
- CB0706050
- Molecular Formula:
- C20H30O4
- Molecular Weight:
- 334.45
- MDL Number:
- MFCD00065805
- MOL File:
- 87893-54-7.mol
- MSDS File:
- SDS
| Boiling point | 531.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.111±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12, |
| form | Liquid |
| pka | 4.75±0.10(Predicted) |
| color | Colorless to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
Delta12-prostaglandin J2 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18550 | Δ12-Prostaglandin J2 ≥95% | 87893-54-7 | 100μg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 18550 | Δ12-Prostaglandin J2 ≥95% | 87893-54-7 | 500μg | $195 | 2026-04-30 | Buy |
| Cayman Chemical | 18550 | Δ12-Prostaglandin J2 ≥95% | 87893-54-7 | 1mg | $344 | 2026-04-30 | Buy |
| ChemScene | CS-0062433 | Delta-12-Prostaglandin J2 99.0% | 87893-54-7 | 100μg(2.99mM*100μLinMethylacetate) | $102 | 2026-06-04 | Buy |
| aablocks | AA004E11 | Δ12-PGJ2 ≥95% | 87893-54-7 | 1mg | $344 | 2026-05-28 | Buy |
Delta12-prostaglandin J2 Chemical Properties, Uses, Production
Description
Δ12-
Uses
Δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 μg/ml. Δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.
Uses
delta12-PGJ2 (delta12-Prostaglandin J2) is a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity.
Definition
ChEBI: 13,14-dihydro-Delta(12)-prostaglandin J2 is a member of the class of prostaglandins J that is prosta-5,9,12-trien-1-oic acid carrying oxo and hydsroxy substituents at positions 11 and 15 respectively (the 5Z,12E,15S-stereoisomer). It has a role as an antineoplastic agent and an antiviral agent. It is a prostaglandins J and a secondary alcohol. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 13,14-dihydro-Delta(12)-prostaglandin J2(1-).
IC 50
Human Endogenous Metabolite
References
[1] F. FITZPATRICK M W. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.[J]. The Journal of Biological Chemistry, 1983, 17 1: 11713-11718. DOI: 10.1016/s0021-9258(17)44287-6
[2] T KATO. Antitumor activity of delta 7-prostaglandin A1 and delta 12-prostaglandin J2 in vitro and in vivo.[J]. Cancer research, 1986, 46 7: 3538-3542.
[3] Y HIRATA. Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine.[J]. The Journal of Biological Chemistry, 1988, 263 32: 16619-16625.
[4] B M FORMAN. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.[J]. Cell, 1995, 83 5: 803-812. DOI: 10.1016/0092-8674(95)90193-0
[5] VICTORIA GóMEZ-ABELLáN . Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish[J]. Developmental and comparative immunology, 2015, 52 2: Pages 182-191. DOI: 10.1016/j.dci.2015.04.017
[6] RALF SCHRDER. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.[J]. PLoS ONE, 2012: e33329. DOI: 10.1371/journal.pone.0033329
Delta12-prostaglandin J2 Preparation Products And Raw materials
Raw materials
Preparation Products
Delta12-prostaglandin J2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 | 2853117764@yongstandards.com | China | 9999 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
