Methyl-2-N-(acetylamino)-dimethyl phosphono acetate
- CAS No.
- 89524-99-2
- Chemical Name:
- Methyl-2-N-(acetylamino)-dimethyl phosphono acetate
- Synonyms
- methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate;Ac-Gly(PO(OMe)2-OMe;Ac-α-phosphonoglycine trimethyl ester;Trimethyl a-(Acetamido)phosphonoacetate;Trimethyl α-(Acetamido)phosphonoacetate;Trimethyl N-acetyl-α-phosphonoglycinate;Trimethyl Alpha-(Acetamido)phosphonoacetate;Methyl-2-N-(acetylamino)-dimethyl phosphono acetate;methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate;Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate
- CBNumber:
- CB0708892
- Molecular Formula:
- C7H14NO6P
- Molecular Weight:
- 239.16
- MDL Number:
- MFCD08443722
- MOL File:
- 89524-99-2.mol
- MSDS File:
- SDS
| Melting point | 88.0-88.5℃ |
|---|---|
| Boiling point | 385.3±32.0 °C(Predicted) |
| Density | 1.253±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.20±0.46(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C7H14NO6P/c1-5(9)8-6(7(10)12-2)15(11,13-3)14-4/h6H,1-4H3,(H,8,9) |
| InChIKey | MXNIODZSMNMILW-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C(NC(C)=O)P(OC)(OC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P261-P271-P280 |
| HazardClass | IRRITANT |
| HS Code | 2915390090 |
Methyl-2-N-(acetylamino)-dimethyl phosphono acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M219250-50MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 50mg | $72 | 2026-06-03 | Buy |
| TRC | TRC-M219250-500MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 500mg | $173 | 2026-06-03 | Buy |
| TRC | TRC-M219250-100MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 100mg | $97 | 2026-06-03 | Buy |
| Apolloscientific | OR310623 | Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | 89524-99-2 | 1g | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR310623 | Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | 89524-99-2 | 5g | $161 | 2026-06-04 | Buy |
Methyl-2-N-(acetylamino)-dimethyl phosphono acetate Chemical Properties, Uses, Production
Uses
Trimethyl α-(Acetamido)phosphonoacetate can be prepared to use as HDAC inhibitor to treat cell proliferative diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.
Synthesis
108-24-7
![methyl ([(benzyloxy)carbonyl]amino)-(dimethoxyphosphoryl)acetate](/CAS/20180601/GIF/100945-15-1.gif)
100945-15-1
89524-99-2
GENERAL STEPS: Compound C152 (12.65 g, 38.2 mmol) and acetic anhydride (9.02 mL, 95.5 mmol) were dissolved in methanol (100 mL), and the mixed solution was transferred to a Parr autoclave. 10% Pd/C catalyst (0.640 g) was added and the hydrogenation reaction was carried out at 45 psi hydrogen pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give an oil. The oil was placed in a depressurized environment and reduced pressure was applied to solidify it. The resulting white solid was dissolved in a small amount of ethyl acetate and pentane was slowly added with vigorous stirring until a precipitate began to form. The precipitate was separated by filtration to give methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate (C153) as a white powder in 87% yield. Mass spectrometry (chemical ionization, CI) analysis showed a molecular ion peak (M+H)+ m/z of 240 for C7H14NO6P.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 8, p. 1277 - 1286
[2] Synthesis, 1984, # 1, p. 53 - 60
[3] Organic Syntheses, 2011, vol. 88, p. 152 - 161
[4] Tetrahedron, 2007, vol. 63, # 51, p. 12740 - 12746
[5] Patent: WO2004/39815, 2004, A2. Location in patent: Page 52 - 53
Methyl-2-N-(acetylamino)-dimethyl phosphono acetate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xinyang Longye Chemical Products Co., Ltd. | 15737681111 | 705829620@qq.com | China | 293 | 58 |
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | targsense@qq.com | China | 110 | 65 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Nanjin Cynthia chemicals Technology Co.,Ltd | 0550-5618439 15951861180 | cynthiachem@163.com | China | 291 | 62 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3829 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
View Latest Price from Methyl-2-N-(acetylamino)-dimethyl phosphono acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2023-12-04 | METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
89524-99-2
|
98 | 100kg | Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | |||
 |
2023-06-26 | methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
|
$200.00 | 10kg | 99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd |
-
- methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
89524-99-2
- 98
- Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
-
- methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
- $200.00
- 99%
- Hebei Mingeng Biotechnology Co., Ltd
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