METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
- CAS No.
- 89524-99-2
- Chemical Name:
- METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
- Synonyms
- methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate;Ac-Gly(PO(OMe)2-OMe;Ac-α-phosphonoglycine trimethyl ester;Trimethyl α-(Acetamido)phosphonoacetate;Trimethyl Alpha-(Acetamido)phosphonoacetate;METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE;methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate;Methyl alpha-(acetylamino)-alpha-(dimethoxyphosphoryl)acetate;Acetic acid, (acetylaMino)(diMethoxyphosphinyl)-, Methyl ester;Acetic acid,2-(acetylaMino)-2-(diMethoxyphosphinyl)-, Methyl ester
- CBNumber:
- CB0708892
- Molecular Formula:
- C7H14NO6P
- Molecular Weight:
- 239.16
- MDL Number:
- MFCD08443722
- MOL File:
- 89524-99-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Trimethyl Alpha-(Acetamido)phosphonoacetate | TRC-M219250-50MG | 50mg | $72 |
| Trimethyl Alpha-(Acetamido)phosphonoacetate | TRC-M219250-500MG | 500mg | $173 |
| Trimethyl Alpha-(Acetamido)phosphonoacetate | TRC-M219250-100MG | 100mg | $97 |
| Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | OR310623 | 1g | $55 |
| Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | OR310623 | 5g | $161 |
| More product size | |||
| Melting point | 88.0-88.5℃ |
|---|---|
| Boiling point | 385.3±32.0 °C(Predicted) |
| Density | 1.253±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.20±0.46(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C7H14NO6P/c1-5(9)8-6(7(10)12-2)15(11,13-3)14-4/h6H,1-4H3,(H,8,9) |
| InChIKey | MXNIODZSMNMILW-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C(NC(C)=O)P(OC)(OC)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P261-P271-P280 |
| HazardClass | IRRITANT |
| HS Code | 2915390090 |
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M219250-50MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 50mg | $72 | 2026-06-03 | Buy |
| TRC | TRC-M219250-500MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 500mg | $173 | 2026-06-03 | Buy |
| TRC | TRC-M219250-100MG | Trimethyl Alpha-(Acetamido)phosphonoacetate | 89524-99-2 | 100mg | $97 | 2026-06-03 | Buy |
| Apolloscientific | OR310623 | Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | 89524-99-2 | 1g | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR310623 | Methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate 97% | 89524-99-2 | 5g | $161 | 2026-06-04 | Buy |
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Chemical Properties,Uses,Production
Uses
Trimethyl α-(Acetamido)phosphonoacetate can be prepared to use as HDAC inhibitor to treat cell proliferative diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.
Synthesis
108-24-7
![methyl ([(benzyloxy)carbonyl]amino)-(dimethoxyphosphoryl)acetate](/CAS/20180601/GIF/100945-15-1.gif)
100945-15-1
89524-99-2
GENERAL STEPS: Compound C152 (12.65 g, 38.2 mmol) and acetic anhydride (9.02 mL, 95.5 mmol) were dissolved in methanol (100 mL), and the mixed solution was transferred to a Parr autoclave. 10% Pd/C catalyst (0.640 g) was added and the hydrogenation reaction was carried out at 45 psi hydrogen pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give an oil. The oil was placed in a depressurized environment and reduced pressure was applied to solidify it. The resulting white solid was dissolved in a small amount of ethyl acetate and pentane was slowly added with vigorous stirring until a precipitate began to form. The precipitate was separated by filtration to give methyl 2-acetamido-2-(dimethoxyphosphoryl)acetate (C153) as a white powder in 87% yield. Mass spectrometry (chemical ionization, CI) analysis showed a molecular ion peak (M+H)+ m/z of 240 for C7H14NO6P.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 8, p. 1277 - 1286
[2] Synthesis, 1984, # 1, p. 53 - 60
[3] Organic Syntheses, 2011, vol. 88, p. 152 - 161
[4] Tetrahedron, 2007, vol. 63, # 51, p. 12740 - 12746
[5] Patent: WO2004/39815, 2004, A2. Location in patent: Page 52 - 53
METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16511 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2023-12-04 | METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
89524-99-2
|
98 | 100kg | Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | |||
 |
2023-06-26 | methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
|
$200.00 | 10kg | 99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd |
-
- methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE
89524-99-2
- 98
- Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
-
- methyl 2-acetamido-2-dimethoxyphosphorylacetate
89524-99-2
- $200.00
- 99%
- Hebei Mingeng Biotechnology Co., Ltd
89524-99-2(METHYL-2-N-(ACETYLAMINO)-DIMETHYL PHOSPHONO ACETATE)Related Search:
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