ChemicalBook >> CAS DataBase List >>(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
![(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Structure](CAS/GIF/135911-02-3.gif)
- CAS No.
- 135911-02-3
- Chemical Name:
- (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
- Synonyms
- RP 67580;Rp 68651;7,7-Diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one;(3aR,7aR)-Octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-4H-isoindol;(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one;(3aR,7aR)-2-(1-Imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenylhexahydro-1H-isoindol-4(2H)-one;4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar-cis)-;4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar,7ar)-
- CBNumber:
- CB0709086
- Molecular Formula:
- C29H30N2O2
- Molecular Weight:
- 438.56
- MDL Number:
- MFCD00903364
- MOL File:
- 135911-02-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-09-12 18:48:28
| storage temp. | Store at +4°C |
|---|---|
| solubility | Soluble to 100 mM in ethanol and to 50 mM in DMSO |
| form | Powder |
| EWG's Food Scores | 1 |
| FDA UNII | 49U9M41BGY |
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 256506 | RP 67580 Asreported | 135911-02-3 | 10mg | $480 | 2026-06-03 | Buy |
| Usbiological | 256506 | RP 67580 Asreported | 135911-02-3 | 50mg | $1338 | 2026-06-03 | Buy |
| ChemScene | CS-0028951 | RP 67580 99.05% | 135911-02-3 | 5mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0028951 | RP 67580 99.05% | 135911-02-3 | 10mg | $325 | 2026-06-04 | Buy |
| ApexBio Technology | B6810 | RP 67580 | 135911-02-3 | 10mg | $594 | 2026-05-06 | Buy |
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Chemical Properties,Uses,Production
Uses
RP 67580 is a neurokinin-1 receptor (NK1) antagonist.
Biological Activity
Potent and selective tachykinin NK 1 receptor antagonist (K i values are 2.9 nM and > 10 μ M for rat NK 1 , and rat NK 2 and NK 3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.
in vivo
RP 67580 (0.03-1 mg/kg; i.v.; single dose) significantly inhibits neurogenic inflammation.
| Animal Model: | Male albino Sprague-Dawley rats |
| Dosage: | 0.03, 0.1, 0.3, 1 mg/kg |
| Administration: | i.v.; single dose |
| Result: | Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg. |
storage
Store at -20°C
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Preparation Products And Raw materials
Raw materials
Preparation Products
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Suppliers
Global( 36)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4979 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5987 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
View Lastest Price from (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one manufacturers
135911-02-3((3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one)Related Search:
RP 67580
(3aR,7aR)-Octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-4H-isoindol
4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar,7ar)-
4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar-cis)-
7,7-Diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
Rp 68651
(3aR,7aR)-2-(1-Imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenylhexahydro-1H-isoindol-4(2H)-one
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
135911-02-3
C29H30N2O2
Tachykinin receptor
