(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one

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(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one manufacturers

  • RP 67580
  • RP 67580 pictures
  • 2025-12-22
  • CAS:135911-02-3
  • Purity:
  • Supply Ability: 10g
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Basic information
Product Name:(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
Synonyms:RP 67580;(3aR,7aR)-Octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-4H-isoindol;4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar,7ar)-;4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar-cis)-;7,7-Diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one;Rp 68651;(3aR,7aR)-2-(1-Imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenylhexahydro-1H-isoindol-4(2H)-one;(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one
CAS:135911-02-3
MF:C29H30N2O2
MW:438.56
EINECS:
Product Categories:Tachykinin receptor
Mol File:135911-02-3.mol
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Structure
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Chemical Properties
storage temp. Store at +4°C
solubility Soluble to 100 mM in ethanol and to 50 mM in DMSO
form Powder
Safety Information
MSDS Information
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Usage And Synthesis
UsesRP 67580 is a neurokinin-1 receptor (NK1) antagonist.
Biological ActivityPotent and selective tachykinin NK 1 receptor antagonist (K i values are 2.9 nM and > 10 μ M for rat NK 1 , and rat NK 2 and NK 3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels.
in vivo

RP 67580 (0.03-1 mg/kg; i.v.; single dose) significantly inhibits neurogenic inflammation.

Animal Model:Male albino Sprague-Dawley rats
Dosage:0.03, 0.1, 0.3, 1 mg/kg
Administration:i.v.; single dose
Result:Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg.
storageStore at -20°C
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one Preparation Products And Raw materials
Tag:(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one(135911-02-3) Related Product Information
(3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one RP67580, [methoxyphenyl-3,5-3H]- 4,4-Diphenylcyclohexanone 1-(Diethylamino)pentan-3-one cis-Octahydroisoindole 4-Phenylcyclohexanone 2-[(dimethylamino)methyl]cyclohexan-1-one