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Diethyl 2-propylImidazoledicarbonate

Diethyl 2-propylImidazoledicarbonate Structure
Diethyl 2-propylImidazoledicarbonate structure
CAS No.
144689-94-1
Chemical Name:
Diethyl 2-propylImidazoledicarbonate
Synonyms
OMSTint-C;Olmesartan Impurity 17;2-propyl-, diethyl ester;Intermediate of olmesartan;carbonic acid carboxy ester;4,5-diethyl-2-propyl-1H-imidazole;Diethyl 2-propylImidazoledicarbote;2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL;Diethyl 2-propylImidazoledicarbonate;OlMesartan IMidazole Diethyl Ester IMpurity
CBNumber:
CB0712929
Molecular Formula:
C12H18N2O4
Molecular Weight:
254.28
MDL Number:
MFCD08062365
MOL File:
144689-94-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:51:22
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Diethyl 2-propylImidazoledicarbonate Properties

Melting point 86 °C
Boiling point 400.9±25.0 °C(Predicted)
Density 1.160±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form powder to crystal
pka 9.25±0.10(Predicted)
color White to Yellow to Orange
CAS DataBase Reference 144689-94-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2933998090
NFPA 704
0
2 0

Diethyl 2-propylImidazoledicarbonate price More Price(77)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D3765 Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T) 144689-94-1 5g $42 2026-04-30 Buy
TCI Chemical D3765 Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T) 144689-94-1 25g $169 2026-04-30 Buy
Usbiological 237339 Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate 144689-94-1 1g $156 2026-06-03 Buy
Usbiological 237339 Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate 144689-94-1 5g $186 2026-06-03 Buy
Usbiological 237339 Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate 144689-94-1 25g $325 2026-06-03 Buy
Product number Packaging Price Buy
D3765 5g $42 Buy
D3765 25g $169 Buy
237339 1g $156 Buy
237339 5g $186 Buy
237339 25g $325 Buy

Diethyl 2-propylImidazoledicarbonate Chemical Properties,Uses,Production

Uses

Diethyl 2-propylImidazoledicarbonate is an intermediate in the synthesis of Olmesartan Medoxomil.

Chemical Properties

Light Yellow Solid

Uses

An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)

Synthesis

2-Propyl-1H-imidazole-4,5-dicarboxy acid

58954-23-7

Ethanol

64-17-5

Diethyl 2-propylImidazoledicarbonate

144689-94-1

General procedure for the synthesis of diethyl 2-propyl-4,5-imidazoledicarboxylate from 2-propyl-1H-imidazole-4,5-dicarboxylic acid and ethanol: 48 mmol of 2-n-propylimidazole-4,5-dicarboxylic acid (synthesized in Example 3) was added to a four-necked flask with 152 mL of ethanol. 20.22 g (165 mmol) of thionyl chloride was added slowly dropwise at liquid temperature over 1 hour and 40 minutes. Subsequently 0.91 g (51 mmol) of water was added and the reaction solution was cooled to room temperature. The reaction mixture was heated to reflux for 5 hours (liquid temperature: 74 °C to room temperature). Upon completion of the reaction, the precipitated inorganic salt was removed by filtration. The filtrate was concentrated and partitioned for extraction by adding 50 mL of ethyl acetate and 60 mL of saturated aqueous sodium bicarbonate. After adjusting the pH of the aqueous layer to 7, 20 mL of ethyl acetate was added. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product of diethyl 2-propyl-4,5-imidazoledicarboxylate. To the crude product, 13.06 g of ethyl acetate and 1.07 g of ethanol were added, concentrated to a product weight of 14.5 g and crystallized. After filtration, it was dried under vacuum at 50°C to obtain diethyl 2-propyl-4,5-imidazoledicarboxylate. The first to third crystals were obtained sequentially by recrystallizing the mother liquor and repeating the recrystallization process according to the same method as in Example 1. By HPLC analysis, the yield was 9.50 g (77%) and the HPLC purity was 99.7% for the first crystal, 99.7% for the second crystal and 99.0% for the third crystal, respectively.

References

[1] Organic Preparations and Procedures International, 2006, vol. 38, # 4, p. 410 - 412
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 323 - 338
[3] Patent: JP5688696, 2015, B2. Location in patent: Paragraph 0097

Diethyl 2-propylImidazoledicarbonate Preparation Products And Raw materials

Raw materials

2-Propyl-1H-imidazole-4,5-dicarboxy acid Butyramidine hydrochloride 2-Chloro-3-oxo-succinic acid diethyl ester Ethanol Thionyl chloride

Preparation Products

4-(1-Hydroxy-1-methylpropyl)-2-propyl-1H-Imidazole-5-carboxylic acidethylester Trityl Olmesartan Medoxomil diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate 1H-Imidazole-5-carboxylic acid, 4-(1-ethyl-1-hydroxypropyl)-2-propyl-, ethyl ester

Diethyl 2-propylImidazoledicarbonate Suppliers

Global( 298)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from Diethyl 2-propylImidazoledicarbonate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diethyl 2-propylImidazoledicarbonate pictures 2026-09-11 Diethyl 2-propylImidazoledicarbonate
144689-94-1
 1KG 98%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Diethyl 2-propylImidazoledicarbonate pictures 2026-06-30 Diethyl 2-propylImidazoledicarbonate
144689-94-1
 1kg 98% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Olmesartan Medoxomil Impurity 27 pictures 2026-03-12 Olmesartan Medoxomil Impurity 27
144689-94-1
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD

Diethyl 2-propylImidazoledicarbonate Spectrum

Diethyl 2-propylImidazoledicarbonate(144689-94-1)1HNMR

144689-94-1(Diethyl 2-propylImidazoledicarbonate)Related Search:

2-Propyl-1H-imidazole-4,5-dicarboxy acid OlMesartan Lactone IMpurity 1-(4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone OlMesartan Ethyl Ester IMpurity 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one
Olmesartan medoxomil impurity I Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Trityl olMesartan MedoxoMil iMpurity II OlMesartan Methyl Ester OlMesartan interMediate iMpurity II
4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan MedoxoMil Butyl IMpurity Olmesartan Impurity 12 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole 4,5-Dimethyl-1,3-dioxol-2-one
4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Olmesartan Olmesartan Impurity 10

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2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL 2-Propylimidazoledicarboxylic acid diethyl ester 2-PROPYL-4,5-IMIDAZOLEDICARBOXYLIC ACID DIETHYL ESTER 98.0% 2-propyl-, diethyl ester 1H-Imidazole-4,5-dicarboxylic acid, 2-propyl-, 4,5-diethyl ester 2-proyl-4,5-imidazoledicarboxylic acid diethyl ester 4,5-diethyl 2-propyl-1H-iMidazole-4,5-dicarboxylate 2-Propyl-1H-iMidazole-4,5-dicarboxylic Acid 4,5-Diethyl Ester OlMesartan IMidazole Diethyl Ester IMpurity 2-Propyl-1H-imidazol-4,5-dicarboxylic acid 4,5-diethyl ester 2-propy-1H-imidazole-4,5-dicarboxylic acid diethyl ester 4,5-diethyl-2-propyl-1H-imidazole carbonic acid carboxy ester Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylat Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate Diethyl 2-propylImidazoledicarbote 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXY ACID DIETHYL ESTER 2-PROPYL-1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID DIETHYL ESTER 1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID,2-PROPYL-DIETHYL ESTER DIETHYL 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLATE Diethyl 2-propylImidazoledicarbonate 2-propyl-1H-imidazole-4,5-dicarboxyaciddiethyl Olmesartan Impurity 17 OMSTint-C Diethyl2-Propyl-1H-imidazole-4,5-dicarboxylate> Diethyl 2-propylImidazoledicarbonate USP/EP/BP Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate Molecular Formula: C12H18N2O4 Molecular Weight: 254.28 Olmesartan Imidazole Diethyl Ester Impurity 2-Propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester Intermediate of olmesartan Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate (Olmesartan Impurity) 144689-94-1 C12H18O4N2 Aromatics Intermediates Organic acids Pharmaceutical material and intermeidates