(+)-alpha-Dihydrotetrabenazine
- CAS No.
- 3466-75-9
- Chemical Name:
- (+)-alpha-Dihydrotetrabenazine
- Synonyms
- DIHYDROTETRABENAZINE;DTBZ;Hydroxy Tetrabenazine;Tetrabenazine Impurity 38;(+)-ALPHA-DIHYDROTETRABEZINE;(+)-alpha-Dihydrotetrabenazine;Hydroxy Tetrabenazine - Mixture of cis and trans Isomers;2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-;2H-BENZO[A]QUINOLIZINE-2-OL, 1,3,4,6,7,11B-HEXAHYDRO-3-ISOBUTYL-9,10-DIMETHOXY-;3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
- CBNumber:
- CB0716932
- Molecular Formula:
- C19H29NO3
- Molecular Weight:
- 319.44
- MDL Number:
- MFCD20275194
- MOL File:
- 3466-75-9.mol
- MSDS File:
- SDS
| Boiling point | 457.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform: soluble; Methanol: soluble |
| form | A solid |
| pka | 14.75±0.40(Predicted) |
| CAS DataBase Reference | 3466-75-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
(+)-alpha-Dihydrotetrabenazine price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27182 | Dihydrotetrabenazine ≥98%(mixtureofisomers) | 3466-75-9 | 500μg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 27182 | Dihydrotetrabenazine ≥98%(mixtureofisomers) | 3466-75-9 | 1mg | $253 | 2026-04-30 | Buy |
| Biosynth | FH76515 | Hydroxy tetrabenazine - Mixture of cis and trans Isomers | 3466-75-9 | 500mg | $290 | 2026-06-04 | Buy |
| Biosynth | FH76515 | Hydroxy tetrabenazine - Mixture of cis and trans Isomers | 3466-75-9 | 1000mg | $480 | 2026-06-04 | Buy |
| Biosynth | FH76515 | Hydroxy tetrabenazine - Mixture of cis and trans Isomers | 3466-75-9 | 2000mg | $1620 | 2026-06-04 | Buy |
(+)-alpha-Dihydrotetrabenazine Chemical Properties, Uses, Production
Description
Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
Chemical Properties
Colourless solid
Uses
Dihydrotetrabenazine (DHTBZ) is the active metabolite of Tetrabenazine (HY-B0590). Dihydrotetrabenazine is the inhibitor for human vesicular monoamine transporter 2 (VMAT2), that reduces monoamine content in presynaptic neurons, and can be used in movement disorder research[1].
Definition
ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines.
References
[1] Chen JJ, et al., Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. Clin Ther. 2012 Jul;34(7):1487-504. DOI:10.1016/j.clinthera.2012.06.010
(+)-alpha-Dihydrotetrabenazine Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-alpha-Dihydrotetrabenazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 9999 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
View Latest Price from (+)-alpha-Dihydrotetrabenazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-02 | (+)-ALPHA-DIHYDROTETRABENAZINE
3466-75-9
|
1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- (+)-ALPHA-DIHYDROTETRABENAZINE
3466-75-9
- $0.10
- 99%
- Shaanxi Dideu Medichem Co. Ltd
