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(+)-alpha-Dihydrotetrabenazine manufacturers
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| | (+)-alpha-Dihydrotetrabenazine Basic information |
| Product Name: | (+)-alpha-Dihydrotetrabenazine | | Synonyms: | 2H-BENZO[A]QUINOLIZINE-2-OL, 1,3,4,6,7,11B-HEXAHYDRO-3-ISOBUTYL-9,10-DIMETHOXY-;2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-;1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol;Hydroxy Tetrabenazine;(+)-ALPHA-DIHYDROTETRABEZINE;9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol;Hydroxy Tetrabenazine - Mixture of cis and trans Isomers;2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)- | | CAS: | 3466-75-9 | | MF: | C19H29NO3 | | MW: | 319.44 | | EINECS: | | | Product Categories: | | | Mol File: | 3466-75-9.mol |  |
| | (+)-alpha-Dihydrotetrabenazine Chemical Properties |
| Boiling point | 457.8±45.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: soluble; Methanol: soluble | | form | A solid | | pka | 14.75±0.40(Predicted) | | CAS DataBase Reference | 3466-75-9 |
| | (+)-alpha-Dihydrotetrabenazine Usage And Synthesis |
| Description | Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum. | | Chemical Properties | Colourless solid | | Uses | Dihydrotetrabenazine (DHTBZ) is the active metabolite of Tetrabenazine (HY-B0590). Dihydrotetrabenazine is the inhibitor for human vesicular monoamine transporter 2 (VMAT2), that reduces monoamine content in presynaptic neurons, and can be used in movement disorder research[1]. | | Definition | ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines. | | References | [1] Chen JJ, et al., Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. Clin Ther. 2012 Jul;34(7):1487-504. DOI:10.1016/j.clinthera.2012.06.010 |
| | (+)-alpha-Dihydrotetrabenazine Preparation Products And Raw materials |
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