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2,3,6-Trimethylphenol

2,3,6-Trimethylphenol structure

CAS No.: 2416-94-6

Chemical Name:: 2,3,6-Trimethylphenol

Synonyms: 2,3,6-Trimethylpenol;Phenol,2,3,6-trimethyl-;FEMA 3963;2,3,6-trimethyl;Trimethylphenol,95%;2,3,6-Trimethy/pheno;2,3,6-TRIMETHYLPHENOL;3-HYDROXYPSEUDOCUMENE;2,3,6-trimethyl-pheno;Ibrutinib Impurity 151

CBNumber:: CB0717010

Molecular Formula:: C9H12O

Molecular Weight:: 136.19

MDL Number:: MFCD00002229

MOL File:: 2416-94-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:50:15

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2,3,6-Trimethylphenol Properties

Melting point	59-62 °C(lit.)
Boiling point	215°C
Density	0.940
refractive index	1.5115 (estimate)
FEMA	3963 \| 2,3,6-TRIMETHYLPHENOL
FLAVIS Number	04.085 \| 2,3,6-Trimethylphenol
Flash point	100
storage temp.	Inert atmosphere,Room Temperature
solubility	methanol: 0.1 g/mL, clear
pka	10.77±0.15(Predicted)
form	powder to crystal
color	White to Orange to Green
Odor	char. antiseptic odor
Water Solubility	1.42g/L at 25℃
JECFA Number	737
Henry's Law Constant	2.5×10⁰ mol/(m³Pa) at 25℃, Duchowicz et al. (2020)
Major Application	flavors and fragrances
Cosmetics Ingredients Functions	PERFUMING
InChI	1S/C9H12O/c1-6-4-5-7(2)9(10)8(6)3/h4-5,10H,1-3H3
InChIKey	QQOMQLYQAXGHSU-UHFFFAOYSA-N
SMILES	Cc1ccc(C)c(O)c1C
LogP	2.80
CAS DataBase Reference	2416-94-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	2,3,6-TRIMETHYLPHENOL
EWG's Food Scores	1
FDA UNII	05WKL2L5LJ
NIST Chemistry Reference	Phenol, 2,3,6-trimethyl-(2416-94-6)
EPA Substance Registry System	2,3,6-Trimethylphenol (2416-94-6)
UNSPSC Code	12352100
NACRES	NA.05

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Danger

Hazard statements

H315-H317-H318-H314

Precautionary statements

P260h-P301+P330+P331-P303+P361+P353-P501a-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P280-P305+P351+P338

Hazard Codes

C,Xi

Risk Statements

37/38-41-36/37/38-34-43-38

Safety Statements

26-39-24/25-45-36/37/39-36/37

RIDADR

UN 2430 8/PG 3

WGK Germany

TSCA

TSCA listed

HS Code

2907.19.2000

HazardClass

PackingGroup

III

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1

Hazardous Substances Data

2416-94-6(Hazardous Substances Data)

REACH Registrations

Active

NFPA 704

	1
2		0

2,3,6-Trimethylphenol price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T0877	2,3,6-Trimethylphenol >98.0%(GC)	2416-94-6	25g	$22	2026-04-30	Buy
TCI Chemical	T0877	2,3,6-Trimethylphenol >98.0%(GC)	2416-94-6	500g	$149	2026-04-30	Buy
Usbiological	291424	2,3,6-Trimethylphenol Asreported	2416-94-6	250g	$365	2026-06-03	Buy
Biosynth	FT54823	2,3,6-Trimethylphenol	2416-94-6	2kg	$900	2026-06-04	Buy
Biosynth	FT54823	2,3,6-Trimethylphenol	2416-94-6	1kg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
T0877	25g	$22	Buy
T0877	500g	$149	Buy
291424	250g	$365	Buy
FT54823	2kg	$900	Buy
FT54823	1kg	$900	Buy

2,3,6-Trimethylphenol Chemical Properties, Uses, Production

Chemical Properties

White or light yellow solid

Uses

2,3,6-Trimethylphenol is used as intermediate for synthetic vitamin E. It is used for manufacturing 2, 3, 5-Trimethylhydroquinone. It is used as intermediate for antioxidants and plastics. It is used as a comonomer for the modification of polyphenylene oxide resins.

Definition

ChEBI: 2,3,6-Trimethylphenol is a hydroxytoluene.

Production Methods

2,3,6-Trimethylphenol is produced selectively by gas phase methylation of m-cresol with methanol at 300–460 ℃ under normal pressure on ortho-selective metal oxide catalysts, as used for the selective methylation of phenol. The reaction occurs in multitube reactors with a fixed catalyst. The reaction temperature to be maintained depends on the catalyst used in each case. Iron oxide catalysts modified with oxides of other metals (e.g., Zn, Cr and Sn, or Mg and Si) are particularly suitable for the process.

Aroma threshold values

Aroma characteristics at 1.0%: sharp smoky phenolic, latakia tobaccolike, tarlike, spicy eugenol and slightly cooling.

Taste threshold values

Taste characteristics at 5 ppm: phenolic, tobaccolike, tarry, medicinal with burnt and woody nuances.

Synthesis Reference(s)

The Journal of Organic Chemistry, 37, p. 2340, 1972 DOI: 10.1021/jo00979a029

Flammability and Explosibility

Non flammable

2,3,6-Trimethylphenol synthesis

Synthesis of 2,3,6-Trimethylphenol from Methanol and m-Cresol

2,3,6-Trimethylphenol Preparation Products And Raw materials

Raw materials

3-Pentanone 4-Methyl-2-pentanone 2,5,6-trimethylcyclohex-2-en-1-one 1-(Trimethylsilyl)-1-propyne 2,5-Dimethylphenol

Methanol 2,3-dimethylphenol 2,5-Dimethylfuran m-Cresol Propyne

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Preparation Products

2,3,6-Trimethylphenol Suppliers

Global Suppliers ( 283)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Xinyue Chemical Co., Ltd.	18116267768	645908973@qq.com	China	124	58
Hangzhou J&H Chemical Co., Ltd.	0571-87396432	sales@jhechem.com	China	14879	59
Weifang QianJin Fine Chemical Co., Ltd.	18753684562	1577399715@qq.COM	China	1773	55
Zibo tailize Chemical Co. , Ltd.	0533-5200592 13173271895	283531267@qq.com	China	24	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Nanjing Datang Chemical Co., Ltd	025-85431992 13951889900	vip@chemdatang.com	China	100	66

Supplier	Advantage
Shanghai Xinyue Chemical Co., Ltd.	58
Hangzhou J&H Chemical Co., Ltd.	59
Weifang QianJin Fine Chemical Co., Ltd.	55
Zibo tailize Chemical Co. , Ltd.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Nanjing Datang Chemical Co., Ltd	66

View Latest Price from 2,3,6-Trimethylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-24	2,3,6-Trimethylphenol 2416-94-6		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-25	2,3,6-Trimethylphenol 2416-94-6	$3.00-9.00		99%		ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-05-28	2,3,6-Trimethylphenol 2416-94-6	$60.00	1KG	99.9%	100000kg	Hebei Chuanghai Biotechnology Co,.LTD

2,3,6-Trimethylphenol
2416-94-6
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2,3,6-Trimethylphenol
2416-94-6
$3.00-9.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2,3,6-Trimethylphenol
2416-94-6
$60.00
99.9%
Hebei Chuanghai Biotechnology Co,.LTD

2,3,6-Trimethylphenol Spectrum

2,3,6-Trimethylphenol(2416-94-6)MS 2,3,6-Trimethylphenol(2416-94-6)¹HNMR 2,3,6-Trimethylphenol(2416-94-6)¹³CNMR 2,3,6-Trimethylphenol(2416-94-6)IR1 2,3,6-Trimethylphenol(2416-94-6)IR2 2,3,6-Trimethylphenol(2416-94-6)Raman

2416-94-6 (2,3,6-Trimethylphenol) Related Search:

2,6-Dimethylphenol Xylenol o-Cresol 4-Trifluoromethylphenol m-Cresol

p-Cresol BORON TRIFLUORIDE-PHENOL COMPLEX (1:2) 3-Trifluoromethylphenol ATRANORIN β-Tocopherol

Trimethylhydroquinone Mycophenolic acid 2,3,5-Trimethylphenol Fumarprotocetraric acid 2,3,5,6-Tetramethyl phenol

Picric acid 2-Hydroxy-3-isopropyl-6-methylbenzoic acid Trolox

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FEMA 3963 3-HYDROXYPSEUDOCUMENE 2,3,6-TRIMETHYLPHENOL 1-Hydroxy-2,3,6-trimethylbenzene 2,3,6-trimethyl-pheno Trimethylphenol,95% 2 3 6-TRIMETHYLPHENOL 97+% 2,3,6-TRIMETHYLPHENOL 95+% 2,3,6- threeMethyl phenol 2,3,6-Trimethylphenol > 2,3,6-Trimethylphenol USP/EP/BP 2,3,6-Trimethy/pheno Ibrutinib Impurity 151 2,3,6-trimethyl 2,3,6-Trimethylphenol 99.5% 2,3,6-Trimethylpenol Phenol,2,3,6-trimethyl- 2416-94-6 ALCOHOL Building Blocks Organic Building Blocks Phenols Oxygen Compounds Phenoles and thiophenoles Organic Building Blocks Oxygen Compounds Phenols Alphabetical Listings Flavors and Fragrances Q-Z Aromatic Phenols