Trolox
- CAS No.
- 53188-07-1
- Chemical Name:
- Trolox
- Synonyms
- TROLOX;(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID;troloxc;TROLOX(R);trolox tm;238813-1G;TROLOXTM C;Trolox(R),97%;Trolox, 97% 1GR;Trolox, 97% 5GR
- CBNumber:
- CB7188583
- Molecular Formula:
- C14H18O4
- Molecular Weight:
- 250.29
- MDL Number:
- MFCD00006846
- MOL File:
- 53188-07-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 187-189 °C (lit.) |
|---|---|
| Boiling point | 313.42°C (rough estimate) |
| Density | 1.0616 (rough estimate) |
| refractive index | 1.4970 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH. |
| form | Crystalline Powder |
| pka | 3.35±0.20(Predicted) |
| color | White to faintly beige |
| Water Solubility |
water: 0.5mg/mL (slightly soluble) ethanol: 150mg/mL methanol: soluble |
| BRN | 1384051 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17) |
| InChIKey | GLEVLJDDWXEYCO-UHFFFAOYSA-N |
| SMILES | C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1 |
| CAS DataBase Reference | 53188-07-1(CAS DataBase Reference) |
| FDA UNII | S18UL9710X |
| EPA Substance Registry System | 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1) |
| UNSPSC Code | 12352205 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DJ2273000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
Trolox price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 238813 | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% | 53188-07-1 | 1g | $85.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 238813 | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% | 53188-07-1 | 5g | $213 | 2026-04-30 | Buy |
| TCI Chemical | H0726 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid >98.0%(GC)(T) | 53188-07-1 | 1g | $67 | 2026-04-30 | Buy |
| TCI Chemical | H0726 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid >98.0%(GC)(T) | 53188-07-1 | 5g | $193 | 2026-04-30 | Buy |
| Cayman Chemical | 10011659 | Trolox ≥98% | 53188-07-1 | 250mg | $43 | 2026-04-30 | Buy |
Trolox Chemical Properties,Uses,Production
Description
Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3
Chemical Properties
white to fainly beige crystalline powder
Uses
An antioxidant derived from water-soluble vitamin E
Uses
Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows. Neuroprotective product.
Definition
ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.
Application
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. lt is commonly used as a standard or positive control in antioxidant assays. In addition, trolox is used to assessthe role of oxidative injury in processes like neuronal cell death and aging. It is effective as adjunctivetherapy in the treatment of certain cancers.
General Description
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.
Mechanism of action
Trolox can protect against oxidative stress, genotoxicity and inflammation induced by CS through ROS scavenging mechanism, and serve as a potential antioxidant prevention strategy against oxidative injury of ATII cells in CS-related lung diseases.
Synthesis
86646-83-5
56305-04-5
Example 7: Synthesis of 6-hydroxy-2,5,7,8-tetramethylbenzodihydropyran-2-carboxylic acid The 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid ester (137.3 kg) obtained in Example 6 was dissolved in methanol (137.3 kg) in a 2000 L reactor equipped with a glass liner. Subsequently, a solution containing water (411 kg) and sodium hydroxide (27 kg) was slowly added dropwise to the reaction mixture over a period of 2 hours and the hydrolysis reaction was carried out at 80 °C for 2 hours. After completion of the reaction, the hydrolysis mixture was neutralized with a solution of potassium bisulfate (91.9 kg) dissolved in water (411.9 kg) at 80 °C for 2 hours. The reaction mixture was separated by centrifugation and the obtained crystals were collected and dried using a conical dryer to finally obtain 6-hydroxy-2,5,7,8-tetramethylbenzodihydropyran-2-carboxylic acid (130.2 kg) in white powder form. The reaction score based on 6-hydroxy-2,3,5-trimethylbenzene and the results of high performance liquid chromatography (HPLC) analysis were as follows: Conversion yield: 99.9% Separation yield: 99.3% Chemical purity: 99.6%
storage
Store at +4°C
References
[1] KENNETH D. MASSEY Karen P B. Free radical damage in neonatal rat cardiac myocyte cultures: Effects of α-tocopherol, trolox, and phytol[J]. Free Radical Biology and Medicine, 1990, 8 5: Pages 449-458. DOI:10.1016/0891-5849(90)90058-q
[2] Q CHEN A I C. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.[J]. Molecular Pharmacology, 1998, 53 4: 638-648. DOI:10.1124/mol.53.4.638
[3] MARIA G. SALGO William A P. Trolox Inhibits Peroxynitrite-Mediated Oxidative Stress and Apoptosis in Rat Thymocytes[J]. Archives of biochemistry and biophysics, 1996, 333 2: Pages 482-488. DOI:10.1006/abbi.1996.0418
Trolox Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| hubei PharmaStandard Co., Ltd. | 027-19050701 13545374703 | cbbspring@163.com | China | 424 | 58 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Guizhou Yituo Chemical Technology Co., Ltd | 18628235590 | wuliming@yituochem.cn | China | 1247 | 58 |
| Shanghai URChem Limited | +86-021-50890968，021-50891159 +86-18601776121 | danny@urchem.com | China | 639 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
Related articles
- Antioxidant effects and research of Trolox
- Trolox is a hydrophilic analogue of vitamin E. Trolox has been used as a standard antioxidant in antioxidant capacity assays.
- May 9,2024
View Lastest Price from Trolox manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-26 | Trolox
53188-07-1
|
$42.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-19 | 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic?acid
53188-07-1
|
$1490.00 | 98 | 5000 Kg | R&D Scientific Inc. | ||
 |
2025-06-27 | 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
53188-07-1
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Trolox
53188-07-1
- $42.00
- 99.89%
- TargetMol Chemicals Inc.
-
- 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic?acid
53188-07-1
- $1490.00
- 98
- R&D Scientific Inc.
-
- 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
53188-07-1
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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