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4-Chloro-3-nitroanisole

4-Chloro-3-nitroanisole structure

CAS No.: 10298-80-3

Chemical Name:: 4-Chloro-3-nitroanisole

Synonyms: 1-CHLORO-4-METHOXY-2-NITROBENZENE;2-CHLORO-5-METHOXYNITROBENZENE;dioxoaMine;Eramod Impurity 2;Iguratimod Impurity 4;Iguratimod Impurity 30;4-chloro-3-nitro-anisol;4-CHLORO-3-NITROANISOLE;3-NITRO-4-CHLOROANISOLE;4-CHLORO-3-NITROANISOLE,98%

CBNumber:: CB0736059

Molecular Formula:: C7H6ClNO3

Molecular Weight:: 187.58

MDL Number:: MFCD00007077

MOL File:: 10298-80-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:52:55

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4-Chloro-3-nitroanisole Properties

Melting point	41-43 °C (lit.)
Boiling point	293°C
Density	1.366
refractive index	1.6000 (estimate)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
color	White to Amber
BRN	640872
InChI	InChI=1S/C7H6ClNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
InChIKey	HISHUMDTGXICEZ-UHFFFAOYSA-N
SMILES	C1(Cl)=CC=C(OC)C=C1[N+]([O-])=O
CAS DataBase Reference	10298-80-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

BZ8580000

Hazard Note

Irritant

HS Code

29093090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
1		0

4-Chloro-3-nitroanisole price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	116289	4-Chloro-3-nitroanisole 98%	10298-80-3	25g	$96.4	2023-06-20	Buy
TCI Chemical	C1225	4-Chloro-3-nitroanisole >98.0%(GC)	10298-80-3	25g	$119	2026-04-30	Buy
Usbiological	267401	4-Chloro-3-nitroanisole Asreported	10298-80-3	25g	$319	2026-06-03	Buy
Usbiological	267401	4-Chloro-3-nitroanisole Asreported	10298-80-3	50g	$432	2026-06-03	Buy
Usbiological	267401	4-Chloro-3-nitroanisole Asreported	10298-80-3	100g	$531	2026-06-03	Buy

Product number	Packaging	Price	Buy
116289	25g	$96.4	Buy
C1225	25g	$119	Buy
267401	25g	$319	Buy
267401	50g	$432	Buy
267401	100g	$531	Buy

4-Chloro-3-nitroanisole Chemical Properties,Uses,Production

Chemical Properties

beige to ochre powder

Uses

4-Chloro-3-nitroanisole can be used as disperse azo dyes.

Uses

4-chloro-3-nitroanisole is used to synthesize a group of derivatives of 7-methanesulfonylamino-6-phenoxychromone at the pyrone and phenoxy rings.

Synthesis

96-96-8

10298-80-3

In a reaction vessel, a concentrated phosphoric acid solution with a mass fraction of 80% and 100 mL of water were added, followed by 4-amino-3-nitroanisole (2) 0.25 mol. The stirring speed was controlled to 230 rpm and the temperature of the solution was lowered to 9 °C. A solution configured from potassium nitrite 0.25 mol dissolved in 100 mL of water was added slowly. A further 200 mL of potassium bisulfite solution with a mass fraction of 55% was added to the reaction vessel, the reaction temperature was maintained at 8 °C, and the reaction lasted for 50 min. 0.30 mol of stannous bromide was dissolved in 130 mL of concentrated potassium chloride solution, and the diazonium salt solution was rapidly added to the stannous bromide solution at 19 °C and allowed to stand for 5 hours. Subsequently, the temperature of the solution was gradually raised to 70 °C until no gas escaped. The distillate was collected by steam distillation and extracted with acetone. The extracts were combined and washed sequentially with sodium bicarbonate solution and potassium chloride solution and finally dehydrated by activated alumina. After recovery of acetone, 43.71 g of yellow solid 4-chloro-3-nitroanisole was obtained in 93% yield.

References

[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: CN104292107, 2016, B. Location in patent: Paragraph 0030; 0031
[3] Patent: CN105439868, 2016, A. Location in patent: Paragraph 0014; 0015
[4] Tetrahedron Letters, 2010, vol. 51, # 51, p. 6769 - 6771
[5] Organic Process Research and Development, 2017, vol. 21, # 1, p. 44 - 51

4-Chloro-3-nitroanisole Preparation Products And Raw materials

Raw materials

Azoic Diazo Component 1 4-Methoxy-2-nitrobenzoic acid Phosphoric acid TIN (II) BROMIDE Potassium bisulfate

Potassium chloride

1of2

Preparation Products

4-Bromo-3-nitroanisole 6-Methoxy-2,3-dihydro-1H-indole 4-Chloro-3-nitrophenol 2-Chloro-5-methoxyaniline

4-Chloro-3-nitroanisole Suppliers

Global( 394)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Buddy Chemical Technology Co., Ltd.	18351236123	buddychem@foxmail.com	China	232	58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.	21-54820552 17702105771	188738128@qq.com	China	300	66
Panjin Greenchem Technology Co., Ltd.	13121959385	chemrocking@bjgreenchem.com	China	223	58
GUANGZHOU AANPHARM TECHNOLOGY CO.,LTD	020-86211473 13925088720	linda@aanpharm.com	China	3641	58
CHANGZHOU GARDE PHARMTECH CO.,LTD	18006124028	gardepharm@163.com	China	119	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Changzhou Buddy Chemical Technology Co., Ltd.	58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.	66
Panjin Greenchem Technology Co., Ltd.	58
GUANGZHOU AANPHARM TECHNOLOGY CO.,LTD	58
CHANGZHOU GARDE PHARMTECH CO.,LTD	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84

View Lastest Price from 4-Chloro-3-nitroanisole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	4-Chloro-3-nitroanisole 10298-80-3	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-05-28	4-Chloro-3-nitroanisole 10298-80-3	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-05-18	4-Chloro-3-nitroanisole 10298-80-3		1kg	98%		Hefei Lbao Physical & Chemical Science Co.,Ltd

4-Chloro-3-nitroanisole
10298-80-3
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

4-Chloro-3-nitroanisole
10298-80-3
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

4-Chloro-3-nitroanisole
10298-80-3
$0.00
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

4-Chloro-3-nitroanisole Spectrum

4-Chloro-3-nitroanisole(10298-80-3)¹HNMR 4-Chloro-3-nitroanisole(10298-80-3)IR 4-Chloro-3-nitroanisole(10298-80-3)FT-IR

10298-80-3(4-Chloro-3-nitroanisole)Related Search:

Azoic Diazo Component 1 4-Methyl-3-nitroanisole 1-Chloro-3-nitrobenzene 4-Bromo-3-nitroanisole 2-Chloro-3-nitrobenzoic acid

4-CHLORO-3-METHYLANISOLE 2-Methyl-3-nitroanisole 4-Chloro-3-nitrobenzoic acid 4-Nitrobenzoic acid 4-Chloro-3-nitrobenzonitrile

N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Iguratimod Impurity 10 Iguratimod N-(4-(2-aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-hydroxy-2-phenoxyphenyl]-

Iguratimod Impurity 11 Phenol Iguratimod Impurity 2

1of4

2-Nitro-4-methoxychlorobenzene 2-CHLORO-5-METHOXYNITROBENZENE 4-CHLORO-3-NITROANISOLE 4-chloro-3-nitro-anisol 4-Chloro-3-Nitroanisole98%(Gc) Benzene, 1-chloro-4-methoxy-2-nitro- 4-methoxy-2-nitrochlorobenzene 3-NITRO-4-CHLOROANISOLE 4-CHLORO-3-NITROANISOLE,98% 1-Chloro-2-nitro-4-methoxybenzene 2-Chloro-5-methoxy-1-nitrobenzene 4-Chloro-3-nitroanisole,1-Chloro-4-methoxy-2-nitrobenzene dioxoaMine 2-Chloro-5-methoxynitrobenzene, 1-Chloro-4-methoxy-2-nitrobenzene, 4-Chloro-3-nitrophenyl methyl ether 4-Chloro-3-nitroanisole, 97+% Iguratimod Impurity 4 4-Chloro-3-nitroanisole > 4-Chloro-3-nitroanisole ISO 9001：2015 REACH Iguratimod Impurity 30 Eramod Impurity 2 3-nitro-4-chlorophenylmethyl ether 1-CHLORO-4-METHOXY-2-NITROBENZENE 10298-80-3 10289-80-3 10298-80-2 10289-80-3 C7H6NO3Cl C7H6CINO3 Building Blocks Organic Building Blocks Nitrogen Compounds Nitro Compounds Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks Anisole Anisoles, Alkyloxy Compounds & Phenylacetates Chlorine Compounds Nitro Compounds FINE Chemical & INTERMEDIATES Miscellaneous