ChemicalBook >> CAS DataBase List >>ICI 89406
ICI 89406
- CAS No.
- 53671-71-9
- Chemical Name:
- ICI 89406
- Synonyms
- C025716;ICI 89406;ICI 89406, 10 mM in DMSO;N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA;1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea;Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-;Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
- CBNumber:
- CB0741961
- Molecular Formula:
- C19H22N4O3
- Molecular Weight:
- 354.4
- MDL Number:
- MFCD00673934
- MOL File:
- 53671-71-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-16 07:06:08
| Melting point | 155-156 °C(Solv: acetonitrile (75-05-8)) |
|---|---|
| Boiling point | 575.0±50.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in ethanol and to 100 mM in DMSO |
| form | Powder |
| pka | 12.29±0.46(Predicted) |
| color | White to off-white |
| FDA UNII | C027IY98WE |
ICI 89406 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42370 | ICI 89406 ≥98% | 53671-71-9 | 5mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 42370 | ICI 89406 ≥98% | 53671-71-9 | 10mg | $97 | 2026-04-30 | Buy |
| Cayman Chemical | 42370 | ICI 89406 ≥98% | 53671-71-9 | 25mg | $229 | 2026-04-30 | Buy |
| Cayman Chemical | 42370 | ICI 89406 ≥98% | 53671-71-9 | 50mg | $432 | 2026-04-30 | Buy |
| Usbiological | 452183 | ICI 89406 | 53671-71-9 | 2.5mg | $305 | 2026-06-03 | Buy |
ICI 89406 Chemical Properties,Uses,Production
Uses
ICI 89406 is beta-1-selective antagonist.
Definition
ChEBI: 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea is a member of ureas.
Biological Activity
β -adrenergic antagonist and low efficacy partial agonist; does not affect resting cardiac parameters.
in vivo
| Animal Model: | Rats[2]. |
| Dosage: | 0.6, 5 or 50 mg/kg. |
| Administration: | Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis). |
| Result: | Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%. |
ICI 89406 Preparation Products And Raw materials
Raw materials
Preparation Products
ICI 89406 Suppliers
Global( 28)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49299 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
53671-71-9(ICI 89406)Related Search:
N-[2-[3-(2-CYANOPHENOXY)-2-HYDROXYPROPYLAMINO]ETHYL]-N'-PHENYLUREA
ICI 89406
C025716
Urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-
1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea
Adrenergic Receptor,Inhibitor,inhibit,ICI-89406,Beta Receptor,ICI 89406,ICI89406
ICI 89406, 10 mM in DMSO
53671-71-9
