Peiminine
- CAS No.
- 18059-10-4
- Chemical Name:
- Peiminine
- Synonyms
- Peimnine;Zhebeinone;PEINININE;PEIMININE;Peimine B;RADDEANINE;Osnovanine;Vertieinon;PEIMINE (RG);Fritillarine
- CBNumber:
- CB0745848
- Molecular Formula:
- C27H43NO3
- Molecular Weight:
- 429.64
- MDL Number:
- MFCD00210542
- MOL File:
- 18059-10-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 267° |
|---|---|
| alpha | D22 -38.5° (c = 1.5 in chloroform) |
| Boiling point | 567.1±50.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated) |
| pka | 14.56±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChIKey | IQDIERHFZVCNRZ-MYFUJZFTNA-N |
| CAS DataBase Reference | 18059-10-4(CAS DataBase Reference) |
| FDA UNII | QUB07U6VTQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H312-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29389090 | |||||||||
| NFPA 704 |
|
Peiminine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89533 | Peiminine phyproof? Reference Substance | 18059-10-4 | 10MG | $459 | 2026-04-30 | Buy |
| TCI Chemical | P2609 | Peiminine | 18059-10-4 | 10MG | $73 | 2026-04-30 | Buy |
| TCI Chemical | P2609 | Peiminine | 18059-10-4 | 50MG | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 29618 | Peiminine ≥98% | 18059-10-4 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 29618 | Peiminine ≥98% | 18059-10-4 | 10mg | $158 | 2026-04-30 | Buy |
Peiminine Chemical Properties, Uses, Production
Description
Peiminine is a natural product found in Fritillaria anhuiensis, Fritillaria ebeiensis, and other organisms with data available.It has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
Corydalis ochotensis var. raddeana also yields this alkaloid which must not be confused with the two bases of the same name previously isolated from Fritillaria raddeana. The structure has been determined from chemical analysis and the ultraviolet, infrared, NMR and mass spectra.
Chemical Properties
Peiminine is an alkaloid isolated from the Chinese drug 'Pei-Mu', the 'Szechuan' variety of which is stated to be obtained from the corms of Fritillaria RoyZei Hook. This base was first prepared by Chou and Chen who gave it the formula C18H22O2N. Other formulae assigned to the alkaloid are C26H43O2N and C25H41O3N. Peiminine yields colourless needles from EtOH and is laevorotatory having [a]D18 - 67.3° (EtOH). It forms a hydrochloride, m.p. 295-8°C; hydrobromide, m.p. 292°C; oxime, m.p. 10SoC (dec.); semicarbazone, m.p. 255-6°C and the phenylhydrazone hydrochloride, m.p. 266°C. The acetyl derivative yields colourless needles from Me2CO, m.p. 174°C, giving a hydrochloride, m.p. 268°C. Chi and his co-workers have found that the free base sinters at 140°C, melts at 147- 8°C and again at 225-6°C after intermediate solidification. These authors consider the alkaloid to be identical with verticilline (q.v.).
Uses
Peiminine is a derivative of Peimine (P218375) a steroidal alkaloid compound extracted from the Fritillaria species of medicinal plants.
Definition
ChEBI: Imperialine is an alkaloid.
in vivo
Peiminine (3mg/kg, intraperitoneal injection, single dose) alleviates inflammatory manifestations and mitigates intestinal tissue damage in an experimental model of ulcerative colitis[2].
Peiminine (10 mg/kg, Intraperitoneal injection, once every 2 days for 6 weeks) prevents bone loss and fat formation in OVX-induced rat model[3].
Peiminine (1-5 mg/kg, are applied to the dorsal skin, once daily for 16 days) inhibits serum IL-6 and TNF-α in the dinitrochlorobenzene (DNCB)-induced Allergic dermatitis animal model[4].
Peiminine (2-5 mg/kg, Intraperitoneal injection, once a day for 4 weeks) has a cardioprotective effect against myocardial infarction-induced myocardial injury and fibrosis in myocardial infarction rat model[5].
Peiminine (1-5 mg/kg, Intraperitoneal injection, single dose) can reduce the damage of inflammatory response to the body and the possibility of pulmonary edema in LPS-induced Acute lung injury model mice[6].
| Animal Model: | ulcerative colitis model[2] |
| Dosage: | 3mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells. Reduced the levels of MPO and NO generated in the rectal tissue. Reduced cell proliferation in spleen cell. Decreased the production of f IL-1β, IL-6, and TNF-α cytokines. Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2. |
| Animal Model: | Ovariectomized (OVX) rat model[3] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Alleviated the bone loss caused by surgical castration. Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone. |
| Animal Model: | Allergic dermatitis model[4] |
| Dosage: | 1 mg/kg, 5 mg/kg |
| Administration: | were applied to the dorsal skin |
| Result: | Alleviated the bone loss caused by surgical castration. Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone. |
IC 50
Caspase 3; Caspase-8; Caspase-9; PARP-1; ERK1; ERK2; Bcl-2; p65
References
Kametani et al., Heterocycles, 4, 723 (1976)
Peiminine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Pureone Bio Technology, CO. LTD | 18302135232 18302135232 | pureonebio@163.com | China | 2973 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Aktin Chemicals, Inc. | 86-28-85159085 | info@aktinchem.com | China | 297 | 62 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
View Latest Price from Peiminine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Peiminine
18059-10-4
|
$71.00-186.00 | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-12 | Peiminine
18059-10-4
|
1KG | 99% | 50000kg/year | Shaanxi Haibo Biotechnology Co., Ltd | ||
 |
2023-02-24 | Peiminine
18059-10-4
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
