2-Fluoro-4-methylbenzoic acid
- CAS No.
- 7697-23-6
- Chemical Name:
- 2-Fluoro-4-methylbenzoic acid
- Synonyms
- RARECHEM AL BO 2237;2-Fluoro-p-toluic Acid;4-Carboxy-3-fluorotoluene;2-Fluoro-4-methylbenzoicaci;2-FLUORO-4-METHYLBENZOIC ACID;2-Fluoro-4-methylbenzoicAcid>Benzoic acid, 2-fluoro-4-methyl-;4-Carboxy-3-fluorotoluene, 2-Fluoro-p-toluic acid
- CBNumber:
- CB0754783
- Molecular Formula:
- C8H7FO2
- Molecular Weight:
- 154.14
- MDL Number:
- MFCD03092906
- MOL File:
- 7697-23-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186-189°C |
|---|---|
| Boiling point | 271.7±20.0 °C(Predicted) |
| Density | 1.258±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.44±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C8H7FO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11) |
| InChIKey | ALFWHEYHCZRVLO-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(C)C=C1F |
| CAS DataBase Reference | 7697-23-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-37 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
2-Fluoro-4-methylbenzoic acid price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0813 | 2-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T) | 7697-23-6 | 1g | $43 | 2026-04-30 | Buy |
| TCI Chemical | F0813 | 2-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T) | 7697-23-6 | 5g | $128 | 2026-04-30 | Buy |
| Biosynth | FF64207 | 2-Fluoro-4-methylbenzoic acid | 7697-23-6 | 1g | $150 | 2026-06-04 | Buy |
| Biosynth | FF64207 | 2-Fluoro-4-methylbenzoic acid | 7697-23-6 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FF64207 | 2-Fluoro-4-methylbenzoic acid | 7697-23-6 | 2g | $150 | 2026-06-04 | Buy |
2-Fluoro-4-methylbenzoic acid Chemical Properties, Uses, Production
Chemical Properties
Light yellow to dark yellow solid
Uses
2-Fluoro-4-methylbenzoic Acid is a useful reagent for preparing tubulin inhibitors for antitumor agents.
Synthesis
352-70-5
865-47-4
7697-23-6
Step A: 3-Fluorotoluene (Compound 1, 18.7 g, 170 mmol) was added to a 500 mL three-necked flask under nitrogen protection and cooled to -78 °C. Subsequently, a THF solution of potassium tert-butoxide (11.0 g, 170 mmol) was slowly added via syringe.After 10 min, a pentane solution of tert-butyllithium (19.0 g, 170 mmol) was slowly added via cannula. The reaction mixture was stirred at -78 °C for 2.5 hours. Upon completion of the reaction, the reaction was quenched with a large amount of crushed fresh dry ice, removed from the -78 °C bath and manually stirred with a metal spatula until the dark brown substance was transformed into a light yellow slurry. After 20 minutes of manual mixing, approximately 500 mL of water was added and the reaction mixture continued to be stirred. Subsequently, the reaction mixture was washed with ether (Et2O) and then acidified with 6N hydrochloric acid to pH less than 3 and extracted again with ether. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give compound 2 (10 g, 45% yield).1H NMR (400 MHz, CDCl3) δ 7.90 (t, 1H), 7.04 (d, 1H), 6.97 (d, 1H), 2.39 (s, 3H).
References
[1] Patent: US2004/176325, 2004, A1. Location in patent: Page/Page column 31; sheet 33
2-Fluoro-4-methylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Nanjing YakeLun Pharmaceutical Co., Ltd. | 025-66096098 3165145969 | sales@accoronpharm.com | China | 3924 | 55 |
| Speranza Chemical Co., Ltd. | 0755-21030354 18126410231 | sales@speranzachem.com | China | 632 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
View Latest Price from 2-Fluoro-4-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-13 | 2-fluoro-4-methylbenzoic acid
7697-23-6
|
1KG | 98% | 100MT/Year | Speranza Chemical Co., Ltd. | ||
 |
2026-03-20 | 2-Fluoro-4-methylbenzoic acid
7697-23-6
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2021-08-12 | 2-Fluoro-4-methylbenzoic acid
7697-23-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-fluoro-4-methylbenzoic acid
7697-23-6
- 98%
- Speranza Chemical Co., Ltd.
-
- 2-Fluoro-4-methylbenzoic acid
7697-23-6
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Fluoro-4-methylbenzoic acid
7697-23-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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