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2-Fluoro-5-nitrotoluene

2-Fluoro-5-nitrotoluene Structure
2-Fluoro-5-nitrotoluene structure
CAS No.
455-88-9
Chemical Name:
2-Fluoro-5-nitrotoluene
Synonyms
1-FLUORO-2-METHYL-4-NITROBENZENE;5-Nitro-2-fluorotoluene;2-Fluoro-5-nitrotoluene,97%;Benzene, 1-fluoro-2-methyl-4-nitro-;uoro-5-nitrotoL;Fluoronitrotoluene;Fluoronitrotoluene2;2-Fluor-5-nitrotoluol;2-Fluoro-5-nitrotluene;2-FLUORO-5-NITROTOLUENE
CBNumber:
CB0775579
Molecular Formula:
C7H6FNO2
Molecular Weight:
155.13
MDL Number:
MFCD00007284
MOL File:
455-88-9.mol
MSDS File:
SDS
Last updated:2026-01-13 11:13:18
Product description Number Pack Size Price
2-Fluoro-5-nitrotoluene 99% F12006 10g $22.9
2-Fluoro-5-nitrotoluene >97.0%(GC) F0276 10g $19
2-Fluoro-5-nitrotoluene >97.0%(GC) F0276 25g $27
1-Fluoro-2-methyl-4-nitrobenzene 409768 500mg $305
1-Fluoro-2-methyl-4-nitrobenzene F597098 1g $55
More product size
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2-Fluoro-5-nitrotoluene Properties

Melting point 38-40 °C (lit.)
Boiling point 99-100 °C/13 mmHg (lit.)
Density 1.3021 (estimate)
Flash point 221 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to lump
color White to Light yellow to Green
BRN 1940341
InChI InChI=1S/C7H6FNO2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,1H3
InChIKey XUCYJGMIICONES-UHFFFAOYSA-N
SMILES C1(F)=CC=C([N+]([O-])=O)C=C1C
CAS DataBase Reference 455-88-9(CAS DataBase Reference)
NIST Chemistry Reference Benzene, 1-fluoro-2-methyl-4-nitro-(455-88-9)
EPA Substance Registry System Benzene, 1-fluoro-2-methyl-4-nitro- (455-88-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-36/37/39-22
RIDADR  UN2811
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29049090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-Fluoro-5-nitrotoluene price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F12006 2-Fluoro-5-nitrotoluene 99% 455-88-9 10g $22.9 2026-03-19 Buy
TCI Chemical F0276 2-Fluoro-5-nitrotoluene >97.0%(GC) 455-88-9 10g $19 2026-03-19 Buy
TCI Chemical F0276 2-Fluoro-5-nitrotoluene >97.0%(GC) 455-88-9 25g $27 2026-03-19 Buy
Usbiological 409768 1-Fluoro-2-methyl-4-nitrobenzene 455-88-9 500mg $305 2021-12-16 Buy
TRC F597098 1-Fluoro-2-methyl-4-nitrobenzene 455-88-9 1g $55 2021-12-16 Buy
Product number Packaging Price Buy
F12006 10g $22.9 Buy
F0276 10g $19 Buy
F0276 25g $27 Buy
409768 500mg $305 Buy
F597098 1g $55 Buy

2-Fluoro-5-nitrotoluene Chemical Properties,Uses,Production

Application

2-Fluoro-5-nitrotoluene can be used as a nonlinear optical material in optical devices for applications such as frequency doubling, optical modulation, and optical detection.

Chemical Properties

white to light yellow crystal powder

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o

Synthesis

2-Chloro-5-nitrotoluene

13290-74-9

2-Fluoro-5-nitrotoluene

455-88-9

General procedure for the synthesis of 2-fluoro-5-nitrotoluene from 2-chloro-5-nitrotoluene: To an oven-dried resealable reaction tube fitted with a stirrer were added aryl halide (20, 0.12 mmol), BrettPhos (6.4 mg, 0.012 mmol, 10 mol%), (COD)Pd(CH2TMS)2 (2.3 mg. 0.006 mmol, 5 mol%), AgF (23 mg, 0.18 mmol) and toluene (2 mL). The reaction tube was then sealed with a screw cap and removed from the glove box, wrapped in aluminum foil and placed in an oil bath preheated to the indicated temperature with thorough stirring. After 12 hours of reaction, the reaction tube was removed from the oil bath and cooled to room temperature. 4-Fluorotoluene (13.2 μL, 0.12 mmol, 1 eq.) and dodecane (27.3 μL, 0.12 mmol, 1 eq.) were added as internal standards. The reaction mixture was filtered through a glass filter fitted with Celite to remove all solids. Finally, the product yield was analyzed by 19F NMR (282 MHz) and the conversion was determined by GC.

References

[1] Patent: US2011/15401, 2011, A1. Location in patent: Page/Page column 17
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 315,316

2-Fluoro-5-nitrotoluene synthesis

13290-74-9
455-88-9
Synthesis of 2-Fluoro-5-nitrotoluene from 2-Chloro-5-nitrotoluene

2-Fluoro-5-nitrotoluene Preparation Products And Raw materials

Raw materials

3-Nitrobenzyl fluoride 2-Methyl-4-nitrophenyl trifluoromethanesulphonate 4-Fluoro-3-methylphenylboronic acid 2-BROMO-5-NITROTOLUENE 2-Fluoro-3-nitrotoluene
2-Fluorotoluene 2-Chloro-5-nitrotoluene 4-Nitrotoluene 4-Nitrobenzylfluoride 2-Fluoro-6-nitrotoluene
2-Fluoro-4-nitrotoluene

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Preparation Products

2-BROMOMETHYL-1-FLUORO-4-NITROBENZENE

2-Fluoro-5-nitrotoluene Suppliers

Global( 388)Suppliers
Supplier Tel Email Country ProdList Advantage
Fluoropharm Co., Ltd.
+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Changzhou Rokechem Technology Co., Ltd.
18758118018 sales001@rokechem.com China 255 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29821 58
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +8613651600618 sales@worldyachem.com China 967 58
Supplier Advantage
Fluoropharm Co., Ltd.
60
Coresyn Pharmatech Co., Ltd.
58
Changzhou Rokechem Technology Co., Ltd.
58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Worldyang Chemical Co.,Ltd. 		58

View Lastest Price from 2-Fluoro-5-nitrotoluene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-5-nitrotoluene pictures 2025-12-01 2-Fluoro-5-nitrotoluene
455-88-9
 US $0.00-0.00 / KG 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Fluoro-5-nitrotoluene pictures 2025-06-27 2-Fluoro-5-nitrotoluene
455-88-9
 US $30.00-10.00 / KG 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
2-Fluoro-5-nitrotoluene pictures 2025-06-20 2-Fluoro-5-nitrotoluene
455-88-9
 US $0.00 / kg 1kg 98% 20 tons Hebei Yanxi Chemical Co., Ltd.

2-Fluoro-5-nitrotoluene Spectrum

2-Fluoro-5-nitrotoluene(455-88-9)MS2-Fluoro-5-nitrotoluene(455-88-9)1HNMR2-Fluoro-5-nitrotoluene(455-88-9)13CNMR2-Fluoro-5-nitrotoluene(455-88-9)IR12-Fluoro-5-nitrotoluene(455-88-9)IR22-Fluoro-5-nitrotoluene(455-88-9)Raman

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