2-Fluoro-5-nitrotoluene
- CAS No.
- 455-88-9
- Chemical Name:
- 2-Fluoro-5-nitrotoluene
- Synonyms
- 1-FLUORO-2-METHYL-4-NITROBENZENE;5-Nitro-2-fluorotoluene;2-Fluoro-5-nitrotoluene,97%;Benzene, 1-fluoro-2-methyl-4-nitro-;uoro-5-nitrotoL;Fluoronitrotoluene;Fluoronitrotoluene2;2-Fluor-5-nitrotoluol;2-Fluoro-5-nitrotluene;2-FLUORO-5-NITROTOLUENE
- CBNumber:
- CB0775579
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD00007284
- MOL File:
- 455-88-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 99-100 °C/13 mmHg (lit.) |
| Density | 1.3021 (estimate) |
| Flash point | 221 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump |
| color | White to Light yellow to Green |
| BRN | 1940341 |
| InChI | InChI=1S/C7H6FNO2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,1H3 |
| InChIKey | XUCYJGMIICONES-UHFFFAOYSA-N |
| SMILES | C1(F)=CC=C([N+]([O-])=O)C=C1C |
| CAS DataBase Reference | 455-88-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-fluoro-2-methyl-4-nitro-(455-88-9) |
| EPA Substance Registry System | Benzene, 1-fluoro-2-methyl-4-nitro- (455-88-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Fluoro-5-nitrotoluene price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F12006 | 2-Fluoro-5-nitrotoluene 99% | 455-88-9 | 10g | $22.9 | 2026-04-30 | Buy |
| TCI Chemical | F0276 | 2-Fluoro-5-nitrotoluene >97.0%(GC) | 455-88-9 | 10g | $19 | 2026-04-30 | Buy |
| TCI Chemical | F0276 | 2-Fluoro-5-nitrotoluene >97.0%(GC) | 455-88-9 | 25g | $27 | 2026-04-30 | Buy |
| Biosynth | FF64617 | 4-Fluoro-3-methylnitrobenzene | 455-88-9 | 0.5kg | $324.5 | 2026-06-04 | Buy |
| Biosynth | FF64617 | 4-Fluoro-3-methylnitrobenzene | 455-88-9 | 1kg | $584.1 | 2026-06-04 | Buy |
2-Fluoro-5-nitrotoluene Chemical Properties, Uses, Production
Application
2-Fluoro-5-nitrotoluene can be used as a nonlinear optical material in optical devices for applications such as frequency doubling, optical modulation, and optical detection.
Chemical Properties
white to light yellow crystal powder
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthesis
13290-74-9
455-88-9
General procedure for the synthesis of 2-fluoro-5-nitrotoluene from 2-chloro-5-nitrotoluene: To an oven-dried resealable reaction tube fitted with a stirrer were added aryl halide (20, 0.12 mmol), BrettPhos (6.4 mg, 0.012 mmol, 10 mol%), (COD)Pd(CH2TMS)2 (2.3 mg. 0.006 mmol, 5 mol%), AgF (23 mg, 0.18 mmol) and toluene (2 mL). The reaction tube was then sealed with a screw cap and removed from the glove box, wrapped in aluminum foil and placed in an oil bath preheated to the indicated temperature with thorough stirring. After 12 hours of reaction, the reaction tube was removed from the oil bath and cooled to room temperature. 4-Fluorotoluene (13.2 μL, 0.12 mmol, 1 eq.) and dodecane (27.3 μL, 0.12 mmol, 1 eq.) were added as internal standards. The reaction mixture was filtered through a glass filter fitted with Celite to remove all solids. Finally, the product yield was analyzed by 19F NMR (282 MHz) and the conversion was determined by GC.
References
[1] Patent: US2011/15401, 2011, A1. Location in patent: Page/Page column 17
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 315,316
2-Fluoro-5-nitrotoluene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing XiLang Chemical Products Co., Ltd. | 18936048580 | chemxilang@163.com | China | 3909 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| Fuxin Xin Kaida Fluorine Chemistry Co., Ltd. | 0418-6566789 13464830066 | sales@xkdchem.com | China | 174 | 58 |
| Hubei Zhuosheng New Material Technology Co., Ltd | 18971238634 | 2189484023@qq.com | China | 497 | 58 |
| Fuxin F-Block Pharmaceutical Co., Ltd. | 15901742157 | 609923428@qq.com | China | 76 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 |
View Latest Price from 2-Fluoro-5-nitrotoluene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-04 | 2-Fluoro-5-nitrotoluene
455-88-9
|
10kg | 99% | 10 tons | Hangzhou Verychem Science And Technology Co.Ltd | ||
 |
2026-06-30 | 2-Fluoro-5-nitrotoluene
455-88-9
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-27 | 2-Fluoro-5-nitrotoluene
455-88-9
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-Fluoro-5-nitrotoluene
455-88-9
- 99%
- Hangzhou Verychem Science And Technology Co.Ltd
-
- 2-Fluoro-5-nitrotoluene
455-88-9
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Fluoro-5-nitrotoluene
455-88-9
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
