3-ACETYL-2-CHLOROPYRIDINE
- CAS No.
- 55676-21-6
- Chemical Name:
- 3-ACETYL-2-CHLOROPYRIDINE
- Synonyms
- 1-(2-chloropyridin-3-yl)ethan-1-one;2-chloro-3-acetylpyridine;3-ACETYL-2-CHLOROPYRIDINE;3-Acetyl-2-chloropyridine 95%;3-Acetyl-2-chloropyridine >1-(2-CHLOROPYRIDIN-3-YL)ETHANONE;1-(2-chloro-3-pyridinyl)ethanone;Ethanone, 1-(2-chloro-3-pyridinyl)-;1-(2-chloro-3-pyridinyl)-1-ethanone;1-(2-Chloropyridin-3-yl)-1-ethanone
- CBNumber:
- CB0781372
- Molecular Formula:
- C7H6ClNO
- Molecular Weight:
- 155.58
- MDL Number:
- MFCD03840751
- MOL File:
- 55676-21-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Acetyl-2-chloropyridine >98.0%(GC) | A2795 | 1g | $51 |
| 3-Acetyl-2-chloropyridine >98.0%(GC) | A2795 | 5g | $149 |
| 3-Acetyl-2-chloropyridine Asreported | 261262 | 1g | $349 |
| 3-Acetyl-2-chloropyridine Asreported | 261262 | 2g | $482 |
| 3-Acetyl-2-chloropyridine Asreported | 261262 | 5g | $688 |
| More product size | |||
| Boiling point | 114°C/15mmHg(lit.) |
|---|---|
| Density | 1.233±0.06 g/cm3(Predicted) |
| refractive index | 1.5440-1.5480 |
| Flash point | >110℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -1.65±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Brown |
| InChI | InChI=1S/C7H6ClNO/c1-5(10)6-3-2-4-9-7(6)8/h2-4H,1H3 |
| InChIKey | WIWIOUAFBHZLNQ-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=CN=C1Cl)C |
| CAS DataBase Reference | 55676-21-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
3-ACETYL-2-CHLOROPYRIDINE price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2795 | 3-Acetyl-2-chloropyridine >98.0%(GC) | 55676-21-6 | 1g | $51 | 2026-04-30 | Buy |
| TCI Chemical | A2795 | 3-Acetyl-2-chloropyridine >98.0%(GC) | 55676-21-6 | 5g | $149 | 2026-04-30 | Buy |
| Usbiological | 261262 | 3-Acetyl-2-chloropyridine Asreported | 55676-21-6 | 1g | $349 | 2026-06-03 | Buy |
| Usbiological | 261262 | 3-Acetyl-2-chloropyridine Asreported | 55676-21-6 | 2g | $482 | 2026-06-03 | Buy |
| Usbiological | 261262 | 3-Acetyl-2-chloropyridine Asreported | 55676-21-6 | 5g | $688 | 2026-06-03 | Buy |
3-ACETYL-2-CHLOROPYRIDINE Chemical Properties,Uses,Production
Uses
3-Acetyl-2-chloropyridine is a reagent used in the synthesis of Volitinib, a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor as an anti-cancer agent.
Synthesis
131674-39-0
55676-21-6
Step 2: Synthesis of 1-(2-chloropyridin-3-yl)ethanone 1-(2-Chloropyridin-3-yl)ethanol (10 g, 0.0635 mol) was dissolved in anhydrous acetone (200 mL), transferred to a 1-liter flask and the reaction was carried out under argon protection. The reaction mixture was cooled to -30 °C, followed by slow addition of pure crushed chromic anhydride (19 g, 0.19 mol). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, 2-propanol (100 mL) was added to quench the reaction, followed by adjusting the pH with aqueous sodium bicarbonate to 8. The reaction mixture was filtered and the solid was washed with chloroform. The organic and aqueous layers were separated and the aqueous layer was further extracted with chloroform (2 x 100 mL). All organic phases were combined and dried with anhydrous sodium sulfate, followed by concentration under reduced pressure to give the crude 1-(2-chloropyridin-3-yl)ethanone as an oil. The crude product was purified by column chromatography to afford the pure 1-(2-chloropyridin-3-yl)ethanone (8 g, 81% yield). * 1H NMR (CDCl3) δ 8.44 (dd, J = 5 and 2 Hz, 1H), 7.91 (dd, J = 7.5 and 2 Hz, 1H), 7.34 (dd, J = 7.5 and 5 Hz, 1H), 2.68 (s, 3H).
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 9, p. 2409 - 2415
[2] Patent: US2006/47126, 2006, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/5759, 2011, A2. Location in patent: Page/Page column 77
[4] Patent: WO2011/84486, 2011, A1. Location in patent: Page/Page column 106; 110-111
[5] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0494
3-ACETYL-2-CHLOROPYRIDINE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2428 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 3-ACETYL-2-CHLOROPYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 3-ACETYL-2-CHLOROPYRIDINE
55676-21-6
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-04-04 | 2-Chloro-3-acetyl-pyridine
55676-21-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-11-26 | 3-Acetyl-2-chloropyridine
55676-21-6
|
1kg | 99%HPLC&GC | 10ton | Nanjing Fred Technology Co., Ltd |
-
- 3-ACETYL-2-CHLOROPYRIDINE
55676-21-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-3-acetyl-pyridine
55676-21-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Acetyl-2-chloropyridine
55676-21-6
- 99%HPLC&GC
- Nanjing Fred Technology Co., Ltd
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