NEO2734
- CAS No.
- 2081072-29-7
- Chemical Name:
- NEO2734
- Synonyms
- EP31670;NEO2734;NEO2734 ，S9648;NEO2734 (EP31670);NEO2734, 10 mM in DMSO;1,3-Dimethyl-5-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-6-yl)-2(1H)-pyridinone;2(1H)-Pyridinone, 1,3-dimethyl-5-[2-(tetrahydro-2H-pyran-4-yl)-1-[2-(trifluoromethoxy)ethyl]-1H-benzimidazol-6-yl]-;PER-403,SPOP,NEO-2734,CBP,NEO 2734,MYC,HAT,NEO2734,Epigenetic Reader Domain,TC-797,Histone Acetyltransferase,p300,HATs,inhibit,Inhibitor,EP-31670,EP 31670
- CBNumber:
- CB08054285
- Molecular Formula:
- C22H24F3N3O3
- Molecular Weight:
- 435.44
- MDL Number:
- MOL File:
- 2081072-29-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501 |
NEO2734 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41030 | NEO2734 ≥98% | 2081072-29-7 | 5mg | $274 | 2026-04-30 | Buy |
| Cayman Chemical | 41030 | NEO2734 ≥98% | 2081072-29-7 | 10mg | $521 | 2026-04-30 | Buy |
| Cayman Chemical | 41030 | NEO2734 ≥98% | 2081072-29-7 | 50mg | $1781 | 2026-04-30 | Buy |
| Cayman Chemical | 41030 | NEO2734 ≥98% | 2081072-29-7 | 100mg | $2739 | 2026-04-30 | Buy |
| Biosynth | GID07229 | 1,3-Dimethyl-5-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-6-yl)-2(1H)-pyridinone | 2081072-29-7 | 25mg | $1164.25 | 2026-06-04 | Buy |
NEO2734 Chemical Properties, Uses, Production
Uses
NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains[1]. NEO2734 is active in SPOP mutant and wild-type prostate cancer[2].
in vivo
NEO2734 (5, 8, 10 mg/kg, orally) inhibits growth and prolongs survival in pre-clinical xenograft models[1].
| Animal Model: | Mice (PER-403 and 14169 models)[1]. |
| Dosage: | 5, 8, 10 mg/kg |
| Administration: | Orally, once daily for 28 days. |
| Result: | Two of the three mice treated with NEO2734 were alive by day 100. Provided markedly improved survival compared with EP, i-BET-762, and even iBET-762+EP by day 100 following initiation of treatment. |
IC 50
CBP/p300
References
[1] Chevaun D Morrison-Smit, et al. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 Jul;19(7):1406-1414. DOI:10.1158/1535-7163.MCT-20-0087
[2] Yuqian Yan, et al. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO Mol Med. 2019 Nov 7;11(11):e10659. DOI:10.15252/emmm.201910659
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
NEO2734 Preparation Products And Raw materials
Raw materials
Preparation Products
NEO2734 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Taifu Pharmaceutical Technology Co. LTD | 021-58111238 18930958102 | sales@taifupharm.com | China | 509 | 55 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
