Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
- CAS No.
- 2089251-33-0
- Chemical Name:
- Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
- Synonyms
- Lipid 5;Lipid 5 (SM-86);nonyl 8-[2-hydroxyethyl-[8-(1-octylnonoxy)-8-oxo-octyl]amino]octanoate;1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate;Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate;Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester
- CBNumber:
- CB08066419
- Molecular Formula:
- C44H87NO5
- Molecular Weight:
- 710.17
- MDL Number:
- MFCD33402176
- MOL File:
- 2089251-33-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 725.8±50.0 °C(Predicted) |
|---|---|
| Density | 0.925±0.06 g/cm3(Predicted) |
| solubility | Soluble in Ethanol, DMSO, DMF |
| pka | 14.67±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| InChIKey | ABCVHPIKBGRCJA-UHFFFAOYSA-N |
| SMILES | C(OC(CCCCCCCC)CCCCCCCC)(=O)CCCCCCCN(CCO)CCCCCCCC(OCCCCCCCCC)=O |
| FDA UNII | P4TKZ45P7A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34372 | Lipid 5 ≥95% | 2089251-33-0 | 10mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 34372 | Lipid 5 ≥95% | 2089251-33-0 | 25mg | $179 | 2026-04-30 | Buy |
| Cayman Chemical | 34372 | Lipid 5 ≥95% | 2089251-33-0 | 50mg | $318 | 2026-04-30 | Buy |
| Cayman Chemical | 34372 | Lipid 5 ≥95% | 2089251-33-0 | 100mg | $561 | 2026-04-30 | Buy |
| ChemScene | CS-0145626 | Lipid 5 ≥98% | 2089251-33-0 | 5mg | $54 | 2026-06-04 | Buy |
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Chemical Properties,Uses,Production
Description
7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate, analog of ALC-0315, is a ionizable, physiological pH cationic synthetic lipid that is used with other lipids to form lipid nanoparticles(LNP) for drug delivery.
Uses
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].
in vivo
Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].
References
[1] Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519. DOI:10.1016/j.ymthe.2018.03.010
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xingji Pharmaceutical (Shanghai) Co., Ltd | 15705593425 | support@utgene.com | China | 302 | 58 |
| Shanghai Chenchu Chemical Co.,ltd. | 13651748127 | 2684615189@qq.com | China | 256 | 58 |
| Hubei Innerse Biotechnology Co., Ltd. | 88189299 18186187538 | 2479490947@qq.com | China | 104 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Tianjin Scaxchem Limited Compnay | 18630949181 | sales@cosychem.com | China | 657 | 55 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7580 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
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