Blosozumab
- CAS No.
- 1132758-87-2
- Chemical Name:
- Blosozumab
- Synonyms
- Blosozumab;Blosozumab (anti-SOST);Research Grade Blosozumab;Research Grade Blosozumab(DHJ48702)
- CBNumber:
- CB08080837
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 83YOM0NEL5 |
Blosozumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CLA1277 | Blosozumab | 1132758-87-2 | 1mg | $618.75 | 2026-06-04 | Buy |
| Biosynth | CLA1277 | Blosozumab | 1132758-87-2 | 10mg | $2062.5 | 2026-06-04 | Buy |
| Biosynth | CLA1277 | Blosozumab | 1132758-87-2 | 100mg | $8250 | 2026-06-04 | Buy |
| ChemScene | CS-0612896 | Blosozumab 99.45% | 1132758-87-2 | 1mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0612896 | Blosozumab 99.45% | 1132758-87-2 | 5mg | $1029 | 2026-06-04 | Buy |
Blosozumab Chemical Properties,Uses,Production
Uses
Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].
in vivo
Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].
| Animal Model: | Sprague-Dawley rats [2] |
| Dosage: | 1, 10, and 100 mg/kg |
| Administration: | Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study) |
| Result: | Observed the bone anabolic effects. Showed significant bleeding and morbidity at 100 mg/kg. Decreases in the numbers of platelets. Increased number of bone marrow megakaryocytes at 100 mg/kg. |
References
[1] Robert R Recker, et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. J Bone Miner Res. 2015 Feb;30(2):216-24. DOI:10.1002/jbmr.2351
[2] Daniel G Rudmann, et al. Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94. DOI:10.1093/toxsci/kfr318
Blosozumab Preparation Products And Raw materials
Raw materials
Preparation Products
Blosozumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
