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Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- structure

CAS No.: 1186654-00-1

Chemical Name:: Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-

Synonyms: Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-

CBNumber:: CB08087689

Molecular Formula:: C18H18F2N2O6S2

Molecular Weight:: 460.47

MDL Number:

MOL File:: 1186654-00-1.mol

Last updated:2026-01-13 13:16:43

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Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Properties

storage temp.	2-8°C
solubility	DMSO: 50mg/mL
form	powder
color	white
InChI	1S/C18H18F2N2O6S2/c19-14-2-1-3-15(20)18(14)30(25,26)22-8-6-21(7-9-22)29(23,24)13-4-5-16-17(12-13)28-11-10-27-16/h1-5,12H,6-11H2
InChIKey	SHWNKRPMUBFWKE-UHFFFAOYSA-N
SMILES	FC(C=CC=C1F)=C1S(N2CCN(S(C3=CC4=C(OCCO4)C=C3)(=O)=O)CC2)(=O)=O
UNSPSC Code	12352200
NACRES	NA.51

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	550602	PKM2 Activator II, DASA The PKM2 Activator II, DASA modulates the biological activity of PKM2. This small molecule/inhibitor is primarily used for Biochemicals applications.	1186654-00-1	10 mg	$264	2026-04-30	Buy

Product number	Packaging	Price	Buy
550602	10 mg	$264	Buy

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Chemical Properties,Uses,Production

Uses

A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC₅₀ = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.

Definition

ChEBI: 1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine is a sulfonamide.

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Merck KGaA	--	ordercn@merckgroup.com	China	6376	58

Supplier	Advantage
Merck KGaA	58

Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- 1186654-00-1