Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Structure
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- structure
CAS No.
2226664-93-1
Chemical Name:
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
Synonyms
Ky19382;A3051;KY19382（A3051）;KY19382 (A3051) ，S6085;KY19382, 10 mM in DMSO;5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382;Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3
CBNumber:
CB08094272
Molecular Formula:
C17H11Cl2N3O2
Molecular Weight:
360.19
MDL Number:
MOL File:
2226664-93-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 18:53:57
Request For Quotation

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Properties

Density 1.58±0.1 g/cm3(Predicted)
solubility DMSO: Soluble
pka 8.80±0.20(Predicted)
form Solid
color Brown to reddish brown
InChI InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23)
InChIKey PROTUMHDKVZVBW-UHFFFAOYSA-N
SMILES N1C2=C(C=C(Cl)C(Cl)=C2)C(=C2C(=NOC)C3=C(N2)C=CC=C3)C1=O

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 37579 KY 19382 ≥95% 2226664-93-1 1mg $65 2026-04-30 Buy
Cayman Chemical 37579 KY 19382 ≥95% 2226664-93-1 5mg $260 2026-04-30 Buy
Cayman Chemical 37579 KY 19382 ≥95% 2226664-93-1 10mg $423 2026-04-30 Buy
Biosynth BPD66493 KY19382 2226664-93-1 1mg $250 2026-06-04 Buy
Biosynth BPD66493 KY19382 2226664-93-1 5mg $337.5 2026-06-04 Buy
Product number Packaging Price Buy
37579 1mg $65 Buy
37579 5mg $260 Buy
37579 10mg $423 Buy
BPD66493 1mg $250 Buy
BPD66493 5mg $337.5 Buy

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Chemical Properties,Uses,Production

Uses

KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β.

in vivo

KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ngh/ml[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2].

Animal Model:C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1]
Dosage:0.1 mg/kg
Administration:I.p. once daily for 2 weeks
Result:Increased nuclear β-catenin in the growth plate chondrocytes dramatically.
Elevated the height of each growth plate zone and BrdU-positive cells.
Did not affect the cartilage resorption of rapidly growing young mice.
Animal Model:SD male rats[1]
Dosage:1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis)
Administration:I.v. and i.p. administration
Result:I.v.: t1/2=3.33 h; AUC=7832.81 ngh/mL; CL=0.12 L/h/kg.
I.p.: t1/2=16.20 h; F=16.74%; Cmax=463.37 ng/mL.

IC 50

CXXC5-DVL: 19 nM (IC50); GSK3β: 10 nM (IC50)

References

[1] SEHEE CHOI. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.[J]. Life Science Alliance, 2019. DOI: 10.26508/lsa.201800254

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan HengHeDa Pharm Co., Ltd. 027-84888681 18086046872 hhdpharm@hotmail.com China 113 55
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9796 55
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
DC Chemicals 021-58447131 13564518121 doncunbiosci@gmail.com China 618 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
Shaanxi Dideu Medichem Co. Ltd +86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3961 58
Supplier Advantage
Wuhan HengHeDa Pharm Co., Ltd. 55
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Dideu Industries Group Limited 58
TargetMol Chemicals Inc. 58
InvivoChem 58
DC Chemicals 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58

View Lastest Price from 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KY19382 (A3051) pictures 2026-09-13 KY19382 (A3051)
2226664-93-1
 $10.00 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Ky19382 pictures 2026-09-10 Ky19382
2226664-93-1
 $370.00-400.00 1g 99% 50 Tons Hebei Dangtong Import and export Co LTD
KY19382 pictures 2026-07-27 KY19382
2226664-93-1
 $100.00-369.00 98.06% 10g TargetMol Chemicals Inc.
  • Ky19382 pictures
  • Ky19382
    2226664-93-1
  • $370.00-400.00
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • KY19382 pictures
  • KY19382
    2226664-93-1
  • $100.00-369.00
  • 98.06%
  • TargetMol Chemicals Inc.

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Spectrum

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-(2226664-93-1)1HNMR

2226664-93-1(2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-)Related Search:

5-Iodoindirubin-3'-monoxime 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime Indirubin-3'-oxime DRAK2-IN-16
7BIO

1of2

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382 Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3 5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one KY19382（A3051） KY19382, 10 mM in DMSO KY19382 (A3051) ，S6085 A3051 Ky19382 2226664-93-1