| Identification | Back Directory | [Name]
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- | [CAS]
2226664-93-1 | [Synonyms]
A3051
Ky19382
KY19382（A3051）
5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one
5',6'-Dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382
Glycogen synthase kinase 3,Beta catenin,β-catenin,GSK-3,KY 19382,inhibit,Wnt,Inhibitor,KY-19382,A 3051,KY19382,A-3051,Glycogen synthase kinase-3 | [Molecular Formula]
C17H11Cl2N3O2 | [MOL File]
2226664-93-1.mol | [Molecular Weight]
360.19 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble | [form ]
Solid | [pka]
8.80±0.20(Predicted) | [color ]
Brown to reddish brown | [InChI]
InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23) | [InChIKey]
PROTUMHDKVZVBW-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(Cl)C(Cl)=C2)C(=C2C(=NOC)C3=C(N2)C=CC=C3)C1=O |
| Hazard Information | Back Directory | [Uses]
KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β. | [in vivo]
KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng?h/ml[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2]. | Animal Model: | C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1] | | Dosage: | 0.1 mg/kg | | Administration: | I.p. once daily for 2 weeks | | Result: | Increased nuclear β-catenin in the growth plate chondrocytes dramatically.
Elevated the height of each growth plate zone and BrdU-positive cells.
Did not affect the cartilage resorption of rapidly growing young mice.
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| Animal Model: | SD male rats[1] | | Dosage: | 1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis) | | Administration: | I.v. and i.p. administration | | Result: | I.v.: t1/2=3.33 h; AUC=7832.81 ng?h/mL; CL=0.12 L/h/kg.
I.p.: t1/2=16.20 h; F=16.74%; Cmax=463.37 ng/mL.
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| [IC 50]
CXXC5-DVL: 19 nM (IC50); GSK3β: 10 nM (IC50) | [References]
[1] SEHEE CHOI. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.[J]. Life Science Alliance, 2019. DOI: 10.26508/lsa.201800254 |
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| Company Name: |
DC Chemicals Gold
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021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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