1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)-
- CAS No.
- 366487-89-0
- Chemical Name:
- 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)-
- Synonyms
- 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)-
- CBNumber:
- CB08148289
- Molecular Formula:
- C23H40N2O4
- Molecular Weight:
- 408.57
- MDL Number:
- MOL File:
- 366487-89-0.mol
- MSDS File:
- SDS
| Boiling point | 561.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.056±0.06 g/cm3(Predicted) |
| pka | 12.95±0.20(Predicted) |
| FDA UNII | 7G9QGX6OG9 |
1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Chemical Properties, Uses, Production
Uses
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2].
IC 50
Caspase-8; Caspase-9; Caspase 3
References
[1] Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20(3):392-9. DOI:10.1038/sj.leu.2404084
[2] Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003.
1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
