CTPB
- CAS No.
- 586976-24-1
- Chemical Name:
- CTPB
- Synonyms
- CTPB;CAS:586976-24-1;CTPB, 10 mM in DMSO;HAT Activator, CTPB;CTPB (enzyme inhibitor);CTPB (enzyme activator);CTPB, p300 HAT activator;N-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-2-ETHOXY-6-PENTADECYL-BENZAMIDE;Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl
- CBNumber:
- CB0840372
- Molecular Formula:
- C31H43ClF3NO2
- Molecular Weight:
- 554.13
- MDL Number:
- MFCD08702707
- MOL File:
- 586976-24-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 560.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.104±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | White to off-white crystalline solid. |
| pka | 12.27±0.70(Predicted) |
| color | white to off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | OYBMVMAXKOGYDC-UHFFFAOYSA-N |
| SMILES | C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1OCC |
CTPB price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | EPS001 | HAT Activator, CTPB ≥97% (H-NMR) | 586976-24-1 | 1mg | $119 | 2023-01-07 | Buy |
| Sigma-Aldrich | EPS001 | HAT Activator, CTPB ≥97% (H-NMR) | 586976-24-1 | 5mg | $336 | 2023-01-07 | Buy |
| Cayman Chemical | 19570 | CTPB ≥98% | 586976-24-1 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 19570 | CTPB ≥98% | 586976-24-1 | 5mg | $172 | 2026-04-30 | Buy |
| ChemScene | CS-0089747 | CTPB 98.0% | 586976-24-1 | 5mg | $206 | 2026-06-04 | Buy |
CTPB Chemical Properties, Uses, Production
Description
CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2
Uses
CTPB is an amide derivative that selectively activates the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. It directly binds p300. CTPB does not alter PCAF HAT or histone deacetylase activity. It dose-dependently increases the acetylation of histones H3 and H4, with maximal effect at 200 μM.
Definition
ChEBI: CTPB is a benzamide obtained by formal condensation of the carboxy group of 2-ethoxy-6-pentadecylbenzoic acid with one of the amino groups of 4-chloro-3-(trifluoromethyl)aniline. It has a role as a histone acetyltransferase activator. It is a member of benzamides, an aromatic ether, a member of monochlorobenzenes and an organofluorine compound.
IC 50
CBP/p300
References
[1] KARANAM BALASUBRAMANYAM. Small molecule modulators of histone acetyltransferase p300.[J]. The Journal of Biological Chemistry, 2003, 278 21: 19134-19140. DOI:10.1074/jbc.m301580200
[2] K. MANTELINGU. Activation of p300 Histone Acetyltransferase by Small Molecules Altering Enzyme Structure: Probed by Surface-Enhanced Raman Spectroscopy[J]. The Journal of Physical Chemistry B, 2007, 111 17: 4527-4534. DOI:10.1021/jp067655s
CTPB Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhamplov Biotechnology Co., LTD | 00-18372743325 18372743325 | 18372743325@163.cn | China | 4926 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 991 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
