2-chloro 3,5-dimethyl pyarazine
- CAS No.
- 38557-72-1
- Chemical Name:
- 2-chloro 3,5-dimethyl pyarazine
- Synonyms
- 2-Chloro-3,5-dimethylpyrazine;2-chloro 3,5-dimethyl pyarazine;Pyrazine, 2-chloro-3,5-dimethyl-;2-Chloro-3,5-dimethyl-1,4-diazine;2-Chloro-3,5-dimethylpyrazine 97%
- CBNumber:
- CB0853583
- Molecular Formula:
- C6H7ClN2
- Molecular Weight:
- 142.59
- MDL Number:
- MFCD00126945
- MOL File:
- 38557-72-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 186.6±35.0℃ (760 Torr) |
|---|---|
| Density | 1.184±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5230 to 1.5270 |
| Flash point | 83.1±11.5℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform, Methanol (Slightly) |
| pka | 0.47±0.10(Predicted) |
| form | Oil |
| color | Colourless |
| CAS DataBase Reference | 38557-72-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H335-H302+H312+H332-H315 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Risk Statements | 36/38 | |||||||||
| Safety Statements | 23-26-36/37/39 | |||||||||
| RIDADR | 1993 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
2-chloro 3,5-dimethyl pyarazine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3118 | 2-Chloro-3,5-dimethylpyrazine >95.0%(GC) | 38557-72-1 | 1g | $148 | 2026-04-30 | Buy |
| Apolloscientific | OR12278 | 2-Chloro-3,5-dimethylpyrazine 97% | 38557-72-1 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS35633 | 2-Chloro-3,5-dimethylpyrazine 97% | 38557-72-1 | 1g | $37 | 2026-06-04 | Buy |
| Apolloscientific | OR12278 | 2-Chloro-3,5-dimethylpyrazine 97% | 38557-72-1 | 5g | $78 | 2026-06-04 | Buy |
| Activate Scientific | AS35633 | 2-Chloro-3,5-dimethylpyrazine 97% | 38557-72-1 | 5g | $124 | 2026-06-04 | Buy |
2-chloro 3,5-dimethyl pyarazine Chemical Properties, Uses, Production
Uses
2-Chloro-3,5-dimethylpyrazine, is a halogenated pyrazine, that can be used as an intermediates in chemical synthesis.
Synthesis
108-50-9
38557-72-1
The general procedure for the synthesis of 2-chloro-3,5-dimethylpyrazine from 2,6-dimethylpyrazine was as follows: first, 7.12 g of 2,6-dimethylpyrazine and 6.5 mL of dimethylformamide (DMF) were added to a three-necked flask fitted with a dropping funnel and a thermometer, and refluxed under nitrogen protection. Subsequently, 6.7 mL of thionyl chloride was added to the dropping funnel and the reaction vessel was cooled in an ice bath. Thionyl chloride was slowly added dropwise while stirring the reaction mixture, controlling the reaction temperature in the range of 45 ± 5 °C. After the dropwise addition was completed, the reaction solution temperature was allowed to drop below 40°C and quenched by slowly adding water. After reconfirming that the temperature of the reaction solution was below 40 °C, aqueous sodium hydroxide was added to adjust the pH to 7-8. Subsequently, the reaction mixture was subjected to hydrodistillation. The distilled aqueous phase was extracted with dichloromethane and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate and filtered, the filtrate was distilled to remove the solvent, and the residue was purified by distillation under reduced pressure to afford the target product 2-chloro-3,5-dimethylpyrazine (clear colorless liquid, 36% yield).
References
[1] Patent: WO2013/112788, 2013, A1. Location in patent: Paragraph 00660
[2] Patent: WO2008/149828, 2008, A1. Location in patent: Page/Page column 80-81; 82
[3] European Journal of Organic Chemistry, 2005, # 19, p. 4141 - 4153
2-chloro 3,5-dimethyl pyarazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Kohn & Shawn Pharmatech Co.,Ltd | 0943-8293106 | sales@kyxpharma.com | China | 297 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
View Latest Price from 2-chloro 3,5-dimethyl pyarazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 2-chloro 3,5-dimethyl pyarazine
38557-72-1
|
$1.00 | 1KG | 99% | 25kg | Career Henan Chemical Co |
-
- 2-chloro 3,5-dimethyl pyarazine
38557-72-1
- $1.00
- 99%
- Career Henan Chemical Co
