2-Chloro-3-methylpyrazine
- CAS No.
- 95-58-9
- Chemical Name:
- 2-Chloro-3-methylpyrazine
- Synonyms
- 2-Chlor-3-methylpyrazin;2-Methyl-3-chloropyrazine;2-Chloro-3-methylpyrazine;Pyrazine, 2-chloro-3-methyl-;2-CHLORO-3,(5),(6)-ETHYLPYRAZINE;2-CHLORO-3-METHYLPYRAZINE ISO 9001：2015 REACH
- CBNumber:
- CB2385570
- Molecular Formula:
- C5H5ClN2
- Molecular Weight:
- 128.56
- MDL Number:
- MFCD00023279
- MOL File:
- 95-58-9.mol
- MSDS File:
- SDS
| Boiling point | 80 °C(Press: 27 Torr) |
|---|---|
| Density | 1.234g/ml |
| refractive index | 1.5283 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -0.31±0.10(Predicted) |
| form | Liquid |
| color | Colorless |
| InChI | InChI=1S/C5H5ClN2/c1-4-5(6)8-3-2-7-4/h2-3H,1H3 |
| InChIKey | WZHWPZQQPWKEAV-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=CN=C1C |
| LogP | 1.058 (est) |
| CAS DataBase Reference | 95-58-9(CAS DataBase Reference) |
| FDA UNII | ZWK9VBZ5ZX |
| EPA Substance Registry System | Pyrazine, 2-chloro-3-methyl- (95-58-9) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2933119000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-3-methylpyrazine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS31734 | 2-Chloro-3-methylpyrazine 98% | 95-58-9 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS31734 | 2-Chloro-3-methylpyrazine 98% | 95-58-9 | 5g | $37 | 2026-06-04 | Buy |
| Activate Scientific | AS31734 | 2-Chloro-3-methylpyrazine 98% | 95-58-9 | 25g | $122 | 2026-06-04 | Buy |
| Activate Scientific | AS31734 | 2-Chloro-3-methylpyrazine 98% | 95-58-9 | 100g | $359 | 2026-06-04 | Buy |
| Matrix Scientific | 073362 | 2-Chloro-3-methylpyrazine | 95-58-9 | 25.00g | $380 | 2026-05-18 | Buy |
2-Chloro-3-methylpyrazine Chemical Properties, Uses, Production
Uses
2-Chloro-3-methylpyrazine is a pyrazine compound in which the chlorine atom in the structure can be replaced for the preparation of other medicinal chemicals. It is used in the preparation of macrocyclic urea kinase inhibitors.
Synthesis
109-08-0
95-58-9
(i) Chlorine gas was passed into carbon tetrachloride (67 mL) at a constant flow rate for 30 minutes. Subsequently, the resulting yellow solution was slowly added dropwise to a solution of carbon tetrachloride (125 mL) containing pyridine (4.8 mL) and 2-methylpyrazine (5 g) over a period of 30 minutes while stirring was maintained. Upon completion of the reaction, the reaction system was purged with nitrogen to remove residual chlorine gas, followed by removal of volatile solvents by rotary evaporation. The resulting brown oily crude product was purified by silica gel column chromatography using dichloromethane as eluent to give 2-chloro-3-methylpyrazine as a final brown oil (3.62 g, 53% yield). The structure of the product was confirmed by 1H NMR (d6-DMSO): δ 6.59 (s, 2H), 7.67 (d, 1H), 7.94 (d, 1H); the mass spectrum (+ve CI) showed the molecular ion peak m/z 129 ([M + H]+).
References
[1] Patent: US5861401, 1999, A
[2] Patent: CN107954913, 2018, A. Location in patent: Paragraph 0021
2-Chloro-3-methylpyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lanzhou Kangyuxin Biotechnology Co., Ltd. | 0943-8293106 | sales@kyxpharma.com | China | 3552 | 58 |
| Jinan Mingjue Biomedical Technology Co., Ltd. | 15628895690 | 1152123767@qq.com | China | 186 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Latest Price from 2-Chloro-3-methylpyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-CHLORO-3-METHYLPYRAZINE
95-58-9
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2022-02-19 | 2-Chloro-3-methyl-pyrazine
95-58-9
|
1KG | 99.5% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-04-29 | 2-Methyl-3-chloropyrazine
95-58-9
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-CHLORO-3-METHYLPYRAZINE
95-58-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-3-methyl-pyrazine
95-58-9
- $0.00
- 99.5%
- Honest Joy Holdings Limited
-
- 2-Methyl-3-chloropyrazine
95-58-9
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
95-58-9 (2-Chloro-3-methylpyrazine) Related Search:
1of4
