Uses
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].
in vivo
Folic acid sodium (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this
behavioral mouse model[2].
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].
| Animal Model: | 30-40 g swiss mice[2] |
| Dosage: | 10, 50, 100 mg/kg |
| Administration: | Oral administration |
| Result: | Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71). |
| Animal Model: | 30-40 g swiss mice[2] |
| Dosage: | 1-10 nmol/site |
| Administration: | Intracerebroventrical injection |
| Result: | Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50). |
| Animal Model: | Virgin female Wistar rats[3] |
| Dosage: | 1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid) |
| Administration: | Oral administration |
| Result: | Prevented epigenetic modification of hepatic gene expression in the offspring. |
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8. DOI:10.1093/ajcn/50.2.353
[2] Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73. DOI:10.1016/j.neuropharm.2007.10.016
[3] Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6. DOI:10.1093/jn/135.6.1382
[4] Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. DOI:10.2165/11532990-000000000-00000
