ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- structure

CAS No.: 2357110-14-4

Chemical Name:: 1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

Synonyms: Thalidomide-Piperazine-PEG2-NH2;5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione,;1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-;5-(4-{2-[2-(2-aminoethoxy)ethoxy]ethyl}piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CBNumber:: CB09018802

Molecular Formula:: C23H31N5O6

Molecular Weight:: 473.52

MDL Number:

MOL File:: 2357110-14-4.mol

Last updated:2025-04-18 09:51:31

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1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- Properties

Boiling point	706.5±60.0 °C(Predicted)
Density	1.333±0.06 g/cm3(Predicted)
pka	10.83±0.40(Predicted)

1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties, Uses, Production

Uses

Thalidomide-Piperazine-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-999. DOI:10.1016/j.str.2020.07.013

1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	9067	58

Supplier	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

2357110-14-4 (1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-) Related Search:

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1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)- 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-Piperazine-PEG2-NH2 5-(4-{2-[2-(2-aminoethoxy)ethoxy]ethyl}piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 2357110-14-4