Pyroxamide
- CAS No.
- 382180-17-8
- Chemical Name:
- Pyroxamide
- Synonyms
- Pyroxamide;NSC 696085;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide, 10 mM in DMSO;Pyroxamide ISO 9001：2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-
- CBNumber:
- CB0950394
- Molecular Formula:
- C13H19N3O3
- Molecular Weight:
- 265.31
- MDL Number:
- MFCD13194970
- MOL File:
- 382180-17-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| color | white to beige |
| InChI | 1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18) |
| InChIKey | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
| SMILES | ONC(=O)CCCCCCC(=O)Nc1cccnc1 |
| NCI Dictionary of Cancer Terms | pyroxamide |
| FDA UNII | 12N86DSS23 |
| NCI Drug Dictionary | pyroxamide |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Pyroxamide price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0296 | Pyroxamide ≥97% (HPLC) | 382180-17-8 | 5mg | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0296 | Pyroxamide ≥97% (HPLC) | 382180-17-8 | 25mg | $407 | 2022-05-15 | Buy |
| Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 5mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 10mg | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 25mg | $275 | 2026-04-30 | Buy |
Pyroxamide Chemical Properties, Uses, Production
Description
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-
Uses
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.
Uses
Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Definition
ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.
IC 50
HDAC1: 100 nM (ID50)
storage
-20°C
References
[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.
Pyroxamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3522 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
View Latest Price from Pyroxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Pyroxamide
382180-17-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-14 | Pyroxamide
382180-17-8
|
$43.00-162.00 | 98.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-23 | Pyroxamide
382180-17-8
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- Pyroxamide
382180-17-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Pyroxamide
382180-17-8
- $43.00-162.00
- 98.77%
- TargetMol Chemicals Inc.
-
- Pyroxamide
382180-17-8
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
