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Medetomidine

Medetomidine Structure
Medetomidine structure
CAS No.
86347-14-0
Chemical Name:
Medetomidine
Synonyms
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;CS-849;Medetomidin;Medetomidine-D5;Medetomidine, BR;Chlorinated TERT butane;Medetomidine，Medetomidine;Dexmedetomidine Impurity 38;Medetomidine HCl Hydrochloride Medetomidine;RAC-4-[1-(2 3-DIMETHYLPHENYL)ETHYL]-1H-I MIDAZOLE
CBNumber:
CB0951588
Molecular Formula:
C13H16N2
Molecular Weight:
200.28
MDL Number:
MFCD00864346
MOL File:
86347-14-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-31 15:25:14
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Medetomidine Properties

Boiling point 381.9±11.0 °C(Predicted)
Density 1.053
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO
pka 14.29±0.10(Predicted)
form Powder
color White to off-white
InChI InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
InChIKey CUHVIMMYOGQXCV-UHFFFAOYSA-N
SMILES C1NC(C(C2=CC=CC(C)=C2C)C)=CN=1
FDA UNII MR15E85MQM

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)Environment (GHS09)
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H300-H330-H336-H370-H372-H410
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501

Medetomidine price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FM45840 Medetomidine 86347-14-0 1g $192.18 2026-06-04 Buy
Biosynth FM45840 Medetomidine 86347-14-0 2g $288.26 2026-06-04 Buy
Biosynth FM45840 Medetomidine 86347-14-0 5g $480.45 2026-06-04 Buy
Biosynth FM45840 Medetomidine 86347-14-0 10g $864.9 2026-06-04 Buy
Biosynth FM45840 Medetomidine 86347-14-0 25g $1152.75 2026-06-04 Buy
Product number Packaging Price Buy
FM45840 1g $192.18 Buy
FM45840 2g $288.26 Buy
FM45840 5g $480.45 Buy
FM45840 10g $864.9 Buy
FM45840 25g $1152.75 Buy

Medetomidine Chemical Properties, Uses, Production

Adverse Reactions

As with all α2-agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists. Incidents of prolonged sedation, bradycardia, cyanosis, vomiting, apnea, death from circulatory failure with severe congestion of lungs, liver, kidney and recurrence of sedation after initial recovery have been reported.

Description

Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.

Uses

Analgesic (veterinary); sedative (veterinary).

Uses

Medetomidine is used in method for synthesizing Medetomidine using 2,3-Dimethylphenylmagnesium Bromide.

Indications

Medetomidine Hydrochloride is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required. The IV route of administration is more efficacious for dental care.

Definition

ChEBI: Medetomidine is a member of imidazoles.

Production Methods

Medetomidine is synthesised through a multi-step organic process that typically begins with the preparation of a substituted imidazole derivative. One efficient route involves a nucleophilic addition reaction between 1-trityl imidazole-4-formaldehyde and 2,3-dimethylphenylmagnesium bromide to form a key intermediate. This is followed by a Wittig olefination step to introduce an alkenyl group, which is then subjected to hydrogenation to yield racemic medetomidine. The final product may be purified and resolved into its enantiomers, most notably dexmedetomidine, using chiral separation techniques such as crystallisation with (+)-tartaric acid.

Mechanism of action

A non-narcotic alpha2-adrenoreceptor agonist

Clinical Use

Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine.

Side effects

Bradycardia with occasional atrioventricular blocks will occur together with decreased respiratory rates. Body temperature is slightly or moderately decreased. Urination typically occurs during recovery at about 90 to 120 minutes posttreatment. In approximately 10% of treated dogs, occasional episodes of vomiting occur between 5 to 15 minutes posttreatment. An increase in blood glucose concentration is seen due to α2-adrenoreceptor-mediated inhibition of insulin secretion.

Veterinary Drugs and Treatments

Medetomidine is labeled for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations and procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures not requiring intubation. The manufacturer recommends the IV route of administration for dental procedures. Medetomidine has also been used in cats, primarily in Europe. But there is apparently much less data available to evaluate its use; caution is advised.

Precautions

In extremely nervous or excited dogs, levels of endogenous catecholamines are high due to the animal’s state of agitation. The pharmacological response elicited by α2-agonists (e.g., medetomidine) in such animals is often reduced, with depth and duration of sedative/analgesic effects ranging from slightly diminished to nonexistent. Highly agitated dogs should therefore be put at ease and allowed to rest quietly prior to receiving Medetomidine Hydrochloride. Allowing dogs to rest quietly for 10 to 15 minutes after injection may improve the response to Medetomidine Hydrochloride. In dogs not responding satisfactorily to treatment with Medetomidine Hydrochloride, repeat dosing is not recommended.

Pesticide Type

Veterinary substance

Medetomidine synthesis

86347-15-1
86347-14-0
Synthesis of Medetomidine from Medetomidine hydrochloride

Medetomidine Preparation Products And Raw materials

Raw materials

1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethenyl]-1-(phenylmethyl)- sodium:cyanide Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) 2-bromo-3-(2,3-dimethylphenyl)butanal N-(Trimethylsilyl)imidazole
Medetomidine hydrochloride 2,3-Dimethylstyrene Methylmagnesium chloride 5-[1-(2,3-DiMethylphenyl)ethenyl]iMidazole Formamidine acetate
Methyllithium N-Boc-imidazole Imidazole

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Preparation Products

Medetomidine Suppliers

Global Suppliers ( 171)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Chengdu Yuyang High-Tech Developing Co., Ltd +86-28-61777709 yygk@yygk.com China 69 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 sales@uhnshanghai.com China 997 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
ShangHai Onsyn-Chemical Technology Co., Ltd. 13917628136 15900795984 572350448@qq.com China 259 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
TargetMol Chemicals Inc. 021-021-33632979 15002134094 marketing@targetmol.com China 7993 58
Supplier Advantage
Chembest Research Laboratories Limited 61
ShangHai YuanYe Biotechnology Co., Ltd. 60
Chengdu Yuyang High-Tech Developing Co., Ltd 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
UHN Shanghai Research & Development Co., Ltd. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
ShangHai Onsyn-Chemical Technology Co., Ltd. 55
MedChemexpress LLC 58
TargetMol Chemicals Inc. 58

Related articles

Related Questions

Ask a question
Q:What is the drug class of medetomidine?Anonymous - Aug 13,2025
A:Medetomidine is a more specific α2-agonist than xylazine and has a lower incidence of side effects. It can be used on its own as a premedicant, or it can be combined with ketamine to provide surgical anesthesia. Medetomidine causes peripheral vasoconstriction, which gives mucous membranes a slight mauve appearance that may be mistaken for cyanosis. The vasoconstriction is not dangerous, but the poor color of the mucous membranes could mask a true cyanosis should it occur.

View Latest Price from Medetomidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Medetomidine pictures 2026-09-17 Medetomidine
86347-14-0
 $10.00 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Medetomidine pictures 2026-09-17 Medetomidine
86347-14-0
 $10.00 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Medetomidine pictures 2026-09-17 Medetomidine
86347-14-0
 $6.00 1kg 99.56 60 tons Jinan Million Pharmaceutical Co., Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • $10.00
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • $10.00
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • $6.00
  • 99.56
  • Jinan Million Pharmaceutical Co., Ltd

Medetomidine Spectrum

Medetomidine(86347-14-0)1HNMR

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( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole (Rs)-4-(alpha,2,3-trimethylbenzyl)imidazol 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)- Medetomidine dl-Medetomidine DoMtor Medetomidina Medetomidina [spanish] Medetomidine [inn:ban] Medetomidinum 1H-IMidazole,5-[1-(2,3-diMethylphenyl)ethyl]- Dexmedetomidine Impurity 36 Dexmedetomidine hydrochloride intermediate3 Medetomidinebase 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole (Medetomidine) 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Chlorinated TERT butane CS-849 Dexmedetomidine Impurity 38 Medetomidin Medetomidine, BR Medetomidine，Medetomidine Medetomidine-D5 Medetomidine HCl Hydrochloride Medetomidine RAC-4-[1-(2 3-DIMETHYLPHENYL)ETHYL]-1H-I MIDAZOLE 86347-14-0 86347-14-0