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Medetomidine

Medetomidine Structure
Medetomidine structure
CAS No.
86347-14-0
Chemical Name:
Medetomidine
Synonyms
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;DoMtor;CS-849;Medetomidin;Medetomidine;Medetomidina;Medetomidinum;dl-Medetomidine;Medetomidine-D5;Medetomidine, BR
CBNumber:
CB0951588
Molecular Formula:
C13H16N2
Molecular Weight:
200.28
MDL Number:
MFCD00864346
MOL File:
86347-14-0.mol
MSDS File:
SDS
Last updated:2026-03-04 10:44:01
Product description Number Pack Size Price
Medetomidine 99.97% CS-0734 10mg $80
Medetomidine A3592 5mg $88
Medetomidine 3506AC 25mg $145
Medetomidine 99.97% CS-0734 50mg $240
4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole J55251 250mg $245
More product size
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Medetomidine Properties

Boiling point 381.9±11.0 °C(Predicted)
Density 1.053
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO
form Powder
pka 14.29±0.10(Predicted)
color White to off-white
InChI InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)
InChIKey CUHVIMMYOGQXCV-UHFFFAOYSA-N
SMILES C1NC(C(C2=CC=CC(C)=C2C)C)=CN=1
FDA UNII MR15E85MQM

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H300-H330-H336-H370-H372-H410
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501

Medetomidine price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0734 Medetomidine 99.97% 86347-14-0 10mg $80 2021-12-16 Buy
ApexBio Technology A3592 Medetomidine 86347-14-0 5mg $88 2021-12-16 Buy
AK Scientific 3506AC Medetomidine 86347-14-0 25mg $145 2021-12-16 Buy
ChemScene CS-0734 Medetomidine 99.97% 86347-14-0 50mg $240 2021-12-16 Buy
AK Scientific J55251 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole 86347-14-0 250mg $245 2021-12-16 Buy
Product number Packaging Price Buy
CS-0734 10mg $80 Buy
A3592 5mg $88 Buy
3506AC 25mg $145 Buy
CS-0734 50mg $240 Buy
J55251 250mg $245 Buy

Medetomidine Chemical Properties,Uses,Production

Adverse Reactions

As with all α2-agonists, the potential for isolated cases of hypersensitivity, including paradoxical response (excitation), exists. Incidents of prolonged sedation, bradycardia, cyanosis, vomiting, apnea, death from circulatory failure with severe congestion of lungs, liver, kidney and recurrence of sedation after initial recovery have been reported.

Description

Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist. The drug has been developed by Orion Pharma. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. In Canada, medetomidine is distributed by Novartis Animal Health. The marketed product is a racemic mixture of two stereoisomers from which dexmedetomidine is the main active isomer.

Uses

Analgesic (veterinary); sedative (veterinary).

Uses

Medetomidine is used in method for synthesizing Medetomidine using 2,3-Dimethylphenylmagnesium Bromide.

Indications

Medetomidine Hydrochloride is indicated for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations, clinical procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures where intubation is not required. The IV route of administration is more efficacious for dental care.

Definition

ChEBI: Medetomidine is a member of imidazoles.

Clinical Use

Medetomidine is a potent non-narcotic α2-adrenoreceptor agonist which produces sedation and analgesia. These effects are dose dependent in depth and duration. Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine.

Side effects

Bradycardia with occasional atrioventricular blocks will occur together with decreased respiratory rates. Body temperature is slightly or moderately decreased. Urination typically occurs during recovery at about 90 to 120 minutes posttreatment. In approximately 10% of treated dogs, occasional episodes of vomiting occur between 5 to 15 minutes posttreatment. An increase in blood glucose concentration is seen due to α2-adrenoreceptor-mediated inhibition of insulin secretion.

Veterinary Drugs and Treatments

Medetomidine is labeled for use as a sedative and analgesic in dogs over 12 weeks of age to facilitate clinical examinations and procedures, minor surgical procedures not requiring muscle relaxation, and minor dental procedures not requiring intubation. The manufacturer recommends the IV route of administration for dental procedures. Medetomidine has also been used in cats, primarily in Europe. But there is apparently much less data available to evaluate its use; caution is advised.

Precautions

In extremely nervous or excited dogs, levels of endogenous catecholamines are high due to the animal’s state of agitation. The pharmacological response elicited by α2-agonists (e.g., medetomidine) in such animals is often reduced, with depth and duration of sedative/analgesic effects ranging from slightly diminished to nonexistent. Highly agitated dogs should therefore be put at ease and allowed to rest quietly prior to receiving Medetomidine Hydrochloride. Allowing dogs to rest quietly for 10 to 15 minutes after injection may improve the response to Medetomidine Hydrochloride. In dogs not responding satisfactorily to treatment with Medetomidine Hydrochloride, repeat dosing is not recommended.

Medetomidine synthesis

86347-15-1
86347-14-0
Synthesis of Medetomidine from Medetomidine hydrochloride

Medetomidine Preparation Products And Raw materials

Raw materials

1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethenyl]-1-(phenylmethyl)- sodium:cyanide Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) 2-bromo-3-(2,3-dimethylphenyl)butanal N-(Trimethylsilyl)imidazole
Medetomidine hydrochloride 2,3-Dimethylstyrene Methylmagnesium chloride 5-[1-(2,3-DiMethylphenyl)ethenyl]iMidazole Formamidine acetate
Methyllithium N-BOC-IMIDAZOLE Imidazole

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Preparation Products

Medetomidine Suppliers

Global( 186)Suppliers
Supplier Tel Email Country ProdList Advantage
RongNa Biotechnology Co.,Ltd 		+86-86-13583358881 +8618560316533 Brad@rongnabiotech.com China 3375 58
Wuhan Haorong Biotechnology Co.,ltd 		+8618565342920 sales@chembj.net China 304 58
WUXI HONOR SHINE CHEMICAL CO.,LTD
+86-0510-83593312 +8619805123561 sales@honorshinechem.com China 69 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191 Jerry@xhobio.com China 870 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838 evan@tyvovo.com China 143 58
Wuhan Biocar Pharmacy CO.,Ltd.
+86-86-13343427080 +8613343427080 wxxxxxxj@gmail.com China 495 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040 1061@dideu.com China 3982 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3998 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3995 58
Anhui Yiao New Material Technology Co., Ltd 		+86-18033737140 +86-17354101231 sales1@hbganmiao.com China 227 58
Supplier Advantage
RongNa Biotechnology Co.,Ltd 		58
Wuhan Haorong Biotechnology Co.,ltd 		58
WUXI HONOR SHINE CHEMICAL CO.,LTD
58
Shaanxi Xianhe Biotech Co., Ltd
58
Guangzhou Tengyue Chemical Co., Ltd.
58
Wuhan Biocar Pharmacy CO.,Ltd.
58
Shaanxi Dideu Medichem Co. Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Anhui Yiao New Material Technology Co., Ltd 		58

Related articles

Related Qustion

Ask a question
Q:What is the drug class of medetomidine?Anonymous - Aug 13，2025
A:Medetomidine is a more specific α2-agonist than xylazine and has a lower incidence of side effects. It can be used on its own as a premedicant, or it can be combined with ketamine to provide surgical anesthesia. Medetomidine causes peripheral vasoconstriction, which gives mucous membranes a slight mauve appearance that may be mistaken for cyanosis. The vasoconstriction is not dangerous, but the poor color of the mucous membranes could mask a true cyanosis should it occur.

View Lastest Price from Medetomidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Medetomidine pictures 2026-03-09 Medetomidine
86347-14-0
 US $10.00 / ASSAYS 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Medetomidine pictures 2026-03-09 Medetomidine
86347-14-0
 US $10.00 / ASSAYS 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Medetomidine pictures 2026-03-09 Medetomidine
86347-14-0
 US $6.00 / kg 1kg 99.56 60 tons Jinan Million Pharmaceutical Co., Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • US $10.00 / ASSAYS
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • US $10.00 / ASSAYS
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • Medetomidine pictures
  • Medetomidine
    86347-14-0
  • US $6.00 / kg
  • 99.56
  • Jinan Million Pharmaceutical Co., Ltd

Medetomidine Spectrum

Medetomidine(86347-14-0)1HNMR

86347-14-0(Medetomidine)Related Search:

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1-(2,3-DIMETHYLPHENYL)PROPAN-1-OL Methanone, (2,3-dimethylphenyl)-1H-imidazol-4-yl- chemistry Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) (2,3-diMethylphenyl)(1H-iMidazol-4-yl)Methanol 4-(1-(2,3-dimethylphenyl)propyl)-1H-imidazole
1-(2,3-DiMethylphenyl)-1-(1H-iMidazol-4-yl)ethanol Medetomidine Impurity 2 Medetomidine Impurity 16 Dexmedetomidine hydrochloride Medetomidine hydrochloride
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4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole ( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole (Rs)-4-(alpha,2,3-trimethylbenzyl)imidazol 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)- Medetomidine dl-Medetomidine DoMtor Medetomidina Medetomidina [spanish] Medetomidine [inn:ban] Medetomidinum 1H-IMidazole,5-[1-(2,3-diMethylphenyl)ethyl]- RAC-4-[1-(2 3-DIMETHYLPHENYL)ETHYL]-1H-I MIDAZOLE Medetomidin Medetomidine, BR CS-849 Medetomidine，Medetomidine Chlorinated TERT butane Medetomidine-D5 Medetomidine HCl Hydrochloride Medetomidine Dexmedetomidine Impurity 38 Dexmedetomidine Impurity 36 Dexmedetomidine hydrochloride intermediate3 Medetomidinebase 4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole (Medetomidine) 86347-14-0 86347-14-0