Dexmedetomidine
- CAS No.
- 113775-47-6
- Chemical Name:
- Dexmedetomidine
- Synonyms
- (S)-5-(1-(2,3-diMethylphenyl)ethyl)-1H-iMidazole;MPV 1440;d-Medetomidine;DEXMEDETOMIDINE;(S)-Medetomidine;(+)-Medetomidine;Dexmedetomidine D6;Dexmedetomidine 98%;Medetomidine (S)-Isomer;Medetomidine Impurity 56
- CBNumber:
- CB41017166
- Molecular Formula:
- C13H16N2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD00880557
- MOL File:
- 113775-47-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 146-149°C |
|---|---|
| Boiling point | 381.9±11.0 °C(Predicted) |
| Density | 1.053±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| pka | 13.89±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 |
| InChIKey | CUHVIMMYOGQXCV-NSHDSACASA-N |
| SMILES | C1NC([C@H](C2=CC=CC(C)=C2C)C)=CN=1 |
| FDA UNII | 67VB76HONO |
| Comptox DTXSID | DTXSID10873388 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H373-H317-H360 |
| Precautionary statements | P260-P314-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Dexmedetomidine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4709 | Dexmedetomidine | 113775-47-6 | 25MG | $104 | 2026-04-30 | Buy |
| Cayman Chemical | 39544 | Dexmedetomidine ≥98% | 113775-47-6 | 10mg | $43 | 2026-04-30 | Buy |
| Cayman Chemical | 39544 | Dexmedetomidine ≥98% | 113775-47-6 | 50mg | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 39544 | Dexmedetomidine ≥98% | 113775-47-6 | 100mg | $215 | 2026-04-30 | Buy |
| Cayman Chemical | 39544 | Dexmedetomidine ≥98% | 113775-47-6 | 250mg | $429 | 2026-04-30 | Buy |
Dexmedetomidine Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. The FDA-approved indications for dexmedetomidine are sedation of intubated and mechanically ventilated patients in the intensive care unit (ICU) and peri-procedural (or peri-operative) sedation of non-intubated patients.
Definition
ChEBI: Dexmedetomidine is a medetomidine. It has a role as an alpha-adrenergic agonist, a non-narcotic analgesic, an analgesic and a sedative. It is an enantiomer of a levomedetomidine.
brand name
Precedex (Hospira).
Side effects
This drug is most commonly given to cause sedation, so extreme sedation/lethargy for a short period of time is an expected side effect. Pale gums and lowered heart and respiratory rates can occur. Rarely, vomiting, diarrhea, and collapse may occur. When injected into the muscle, this medication can cause temporary pain at the injection site.
Mode of action
The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.
References
https://www.statpearls.com/articlelibrary/viewarticle/20424/
https://pubchem.ncbi.nlm.nih.gov/compound/dexmedetomidine
https://www.drugs.com/mtm/dexmedetomidine.html
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting DOI: 10.1007/s40265-015-0419-5
Dexmedetomidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Tianhong Medicine Chemical Technology Co.,Ltd. | 18949937116 | dongye.huaxue@126.com | China | 142 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 15343 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Chengdu Yuyang High-Tech Developing Co., Ltd | +86-28-61777709 | yygk@yygk.com | China | 69 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29975 | 65 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
View Latest Price from Dexmedetomidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Dexmedetomidine
113775-47-6
|
$39.00-97.00 | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | Dexmedetomidine
113775-47-6
|
$50.00 | 1kg | 0.99 | 10000 | Hebei Yanxi Chemical Co., Ltd. | |
 |
2022-11-01 | Dexmedetomidine
113775-47-6
|
$10.00 | 1kg | 0.99 | 20tons | Shanghai Quedan biology science and technology co., ltd |
-
- Dexmedetomidine
113775-47-6
- $39.00-97.00
- 99.96%
- TargetMol Chemicals Inc.
-
- Dexmedetomidine
113775-47-6
- $50.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Dexmedetomidine
113775-47-6
- $10.00
- 0.99
- Shanghai Quedan biology science and technology co., ltd
