TAS 205
- CAS No.
- 1584160-52-0
- Chemical Name:
- TAS 205
- Synonyms
- TAS 205;4-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-1-piperazinecarboxamide, monohydrate;1-Piperazinecarboxamide, 4-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-, hydrate (1:1)
- CBNumber:
- CB09739358
- Molecular Formula:
- C27H36N6O4.H2O
- Molecular Weight:
- 526.63
- MDL Number:
- MOL File:
- 1584160-52-0.mol
- MSDS File:
- SDS
TAS 205 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33261 | TAS 205 ≥98% | 1584160-52-0 | 1mg | $95 | 2026-04-30 | Buy |
| Cayman Chemical | 33261 | TAS 205 ≥98% | 1584160-52-0 | 5mg | $392 | 2026-04-30 | Buy |
| Biosynth | JNC16052 | TAS 205 | 1584160-52-0 | 10mg | $1125.5 | 2026-06-04 | Buy |
| Biosynth | JNC16052 | TAS 205 | 1584160-52-0 | 25mg | $1835.25 | 2026-06-04 | Buy |
| Biosynth | JNC16052 | TAS 205 | 1584160-52-0 | 50mg | $2936 | 2026-06-04 | Buy |
TAS 205 Chemical Properties, Uses, Production
Uses
Pizuglanstat hydrate (TAS-205) is a hematopoietic prostaglandin D synthase (HPGDS) inhibitor. TAS-205 selectively inhibits the synthesis of prostaglandin D2 (PGD2) in cell-based enzymatic tests and in vivo models, and effectively reduces the entry of eosinophils into the nasal cavity and late-stage nasal congestion. When used in combination with montelukast (HY-13315A), TAS-205 showed a significant synergistic inhibitory effect; when used in combination with fexofenadine (HY-B0801A), it also had a certain inhibitory effect on early and late nasal congestion.
Biological Activity
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 55.8 nM).1 It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2 induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50 values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.
References
1.Aoyagi, H., Kajiwara, D., Tsunekuni, K., et al.Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitisEur. J. Pharmacol.875173030(2020)
TAS 205 Preparation Products And Raw materials
Raw materials
Preparation Products
TAS 205 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ChemeGen | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
