Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Structure
3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- structure
CAS No.
1033836-12-2
Chemical Name:
3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-
Synonyms
CS-1438;MDK36122;HPGDS inhibitor 1;HPGDS inhibitor 1, >=98%;HPGDS inhibitor 1, 10 mM in DMSO;Prostaglandin D Synthase (hematopoietic-type) Inhibitor I;6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinaMide;6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide;3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-
CBNumber:
CB22599009
Molecular Formula:
C19H19F4N3O
Molecular Weight:
381.37
MDL Number:
MFCD18206776
MOL File:
1033836-12-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:35
Request For Quotation

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Properties

Boiling point 487.2±45.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO
form crystalline solid
pka 9.55±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 1033836-12-2 1mg $134 2026-04-30 Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 1033836-12-2 5mg $333 2026-04-30 Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 1033836-12-2 10mg $598 2026-04-30 Buy
ChemScene CS-1801 HPGDS inhibitor 1 99.42% 1033836-12-2 5mg $157 2026-06-04 Buy
ChemScene CS-1801 HPGDS inhibitor 1 99.42% 1033836-12-2 10mg $244 2026-06-04 Buy
Product number Packaging Price Buy
16256 1mg $134 Buy
16256 5mg $333 Buy
16256 10mg $598 Buy
CS-1801 5mg $157 Buy
CS-1801 10mg $244 Buy

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Chemical Properties, Uses, Production

Uses

HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX[1].

Biological Activity

hpgds inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin d synthase (hpgds) with ic50 value of 0.7nm [1].prostaglandin d2 (pgd2) is a mediator of allergy and inflammation. it is isomerized from pgh2 by pgds. this production is important in airway allergic and inflammatory processes. hpgds inhibitor 1 has a 3-fluorine substituent, making it stable in the in vitro human microsome assay. it has potent effects in enzyme assay and cellular assay with ic50 values of 0.7nm and 32nm, respectively. in addition, the potency is equal against purified hpgds from various species with ic50 values ranging from 0.5-2.3nm. besides that, hpgds inhibitor 1 is selective against hpgds over other relevant human enzymes including l-pgds, mpges, cox-1, cox-2 and 5 lox [1].in a model of antigen-induced airway response in allergic sheep, treatment of hpgds inhibitor 1 completely prevents the late asthma reaction and blocks the airway hyper-responsiveness [1].

in vitro

HPGDS inhibitor 1 has equal potency against purified HPGDS from human, rat, dog, and sheep (IC 50 , 0.5-2.3 nM).

in vivo

HPGDS inhibitor 1 (compound 8; 1 mg/kg) has excellent PK characteristics with 76% bioavailability, and the T 1/2 is 4.1 hours in rats.
Rats dosed orally with 1 mg/kg and 10 mg/kg HPGDS inhibitor 1 (compound 8) are sacrificed at various times. Oral administration of it blocks PGD2 production in the rat spleen; inhibition of PGD2 is inversely correlated with the plasma concentration of it in a time- and dose-dependent manner.
It (compound 8; 1 mg/mL) illustrates efficacy in an in vivo sheep model of asthma.

target

IC50: 0.6 nM (HPGDS in enzyme assays) and 32 nM (HPGDS in cellular assays)

References

[1] carron c p, trujillo j i, olson k l, et al. discovery of an oral potent selective inhibitor of hematopoietic prostaglandin d synthase (hpgds). acs medicinal chemistry letters, 2010, 1(2): 59-63.

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Suppliers

Global Suppliers ( 96)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Shanghai JiYi Biotechnology Co. Ltd. 13621943973 sales@shjiyipharmatech.com China 1166 55
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
D&C Chemicals +86-21-58447131 1724405207@qq.com China 470 55
Supplier Advantage
BOC Sciences 65
Shanghai Topbiochem Technology Co., Ltd 58
Haoyuan Chemexpress Co., Ltd. 61
AdooQ BioScience, LLC 58
CEG Chemical Science&Technology Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
AdooQ Bioscience CHINA 60
Shanghai JiYi Biotechnology Co. Ltd. 55
LETOPHARM LIMITED 58
D&C Chemicals 55

View Latest Price from 3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
HPGDS inhibitor 1 pictures 2026-07-14 HPGDS inhibitor 1
1033836-12-2
 $44.00-173.00 99.16% 10g TargetMol Chemicals Inc.
3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- pictures 2019-12-25 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
1033836-12-2
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- Spectrum

3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-(1033836-12-2)1HNMR

1033836-12-2 (3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-) Related Search:

4-Aminodiphenylamine N-Methylbenzamide 3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- NA Prostaglandin D Synthase (hematopoietic-type) Polyclonal Antibody
H-PGDS

1of2

HPGDS inhibitor 1 6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide 6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinaMide HPGDS inhibitor 1, >=98% Prostaglandin D Synthase (hematopoietic-type) Inhibitor I CS-1438 MDK36122 HPGDS inhibitor 1, 10 mM in DMSO 3-Pyridinecarboxamide, 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]- 1033836-12-2 Inhibitors