15-Keto prostaglandin E2
- CAS No.
- 26441-05-4
- Chemical Name:
- 15-Keto prostaglandin E2
- Synonyms
- (Z)-7-((1R,2R,3R)-3-Hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid;15-KetoPGE2;15-Oxoprostaglandin E2;15-Keto prostaglandin E2;15-Dehydroprostaglandin E2;Dinoprostone EP Impurity F;15-keto Prostaglandin E2 MaxSpecStandard;Alprostadil (Prostaglandin E1) Impurity 6;Alprostadil (prostaglandin E1) Impurity 14;15-keto Prostaglandin E2 Lipid Maps MS Standard
- CBNumber:
- CB0125323
- Molecular Formula:
- C20H30O5
- Molecular Weight:
- 350.45
- MDL Number:
- MFCD00065754
- MOL File:
- 26441-05-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 534.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.144±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2) |
| form | A crystalline solid |
| pka | 4.75±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 2S0F1FTK13 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
15-Keto prostaglandin E2 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14720 | 15-keto Prostaglandin E2 ≥98% | 26441-05-4 | 500μg | $72 | 2026-04-30 | Buy |
| Cayman Chemical | 14720 | 15-keto Prostaglandin E2 ≥98% | 26441-05-4 | 1mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 14720 | 15-keto Prostaglandin E2 ≥98% | 26441-05-4 | 5mg | $556 | 2026-04-30 | Buy |
| Cayman Chemical | 14720 | 15-keto Prostaglandin E2 ≥98% | 26441-05-4 | 10mg | $973 | 2026-04-30 | Buy |
| Cayman Chemical | 10007215 | 15-keto Prostaglandin E2 MaxSpec? Standard ≥95% | 26441-05-4 | 100μg | $106 | 2023-06-20 | Buy |
15-Keto prostaglandin E2 Chemical Properties, Uses, Production
Description
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item Nos. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 μM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 μM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 μM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 μM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells. 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner. It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.
15-keto PGE2 MaxSpec® standard is a quantitative grade standard of 15-keto PGE2 that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 15-keto PGE2 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Uses
15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH. In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).[Cayman Chemical]
Uses
15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes.
Definition
ChEBI: 15-dehydro-prostaglandin E2 is a prostaglandins E. It is functionally related to a prostaglandin E2. It is a conjugate acid of a 15-dehydro-prostaglandin E2(1-).
References
[1] N. NISHIGAKI A I M Negishi. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.[J]. Molecular Pharmacology, 1996, 146 1: 1031-1037. DOI: 10.1254/fpj.108.supplement_65
[2] SUZU ENDO. 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling.[J]. The Journal of Biological Chemistry, 2020: 13338-13352. DOI: 10.1074/jbc.ra120.013988
[3] LISA SCHMIDLEITHNER. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.[J]. Immunity, 2019: 1232-1248.e14. DOI: 10.1016/j.immuni.2019.03.014
[4] ING-JUNG CHEN . Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis[J]. Free Radical Biology and Medicine, 2018, 115: Pages 113-126. DOI: 10.1016/j.freeradbiomed.2017.11.016
[5] CARLOS ARTéRIO SORGI. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays[J]. Scientific Data, 2018, 5 1: 1-12. DOI: 10.1038/sdata.2018.167
[6] CHRISTOPHER G. PARKER. Ligand and Target Discovery by Fragment-Based Screening in Human Cells[J]. Cell, 2017, 168 1: 527-541.e29. DOI: 10.1016/j.cell.2016.12.029
15-Keto prostaglandin E2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2468 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9533 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
View Latest Price from 15-Keto prostaglandin E2 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | 15-keto-Prostaglandin E2
26441-05-4
|
$1160.00-2090.00 | 98.31% | 10g | TargetMol Chemicals Inc. |
-
- 15-keto-Prostaglandin E2
26441-05-4
- $1160.00-2090.00
- 98.31%
- TargetMol Chemicals Inc.
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