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ChemicalBook >> CAS DataBase List >>Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Structure
Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- structure
CAS No.
1971937-18-4
Chemical Name:
Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-
Synonyms
ARN19702;ARN19702,ARN-19702;ARN19702, 10 mM in DMSO;(S)-(2-(Ethylsulfonyl)phenyl)(4-(6-fluorobenzo[d]thiazol-2-yl)-2-methylpiperazin-1-yl)methanone;Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-;2-[(3S)-4-{[2-(ethanesulfonyl)phenyl]carbonyl}-3-methylpiperazin-1-yl]-6-fluoro-1,3-benzothiazole - [AC78069]
CBNumber:
CB09788907
Molecular Formula:
C21H22FN3O3S2
Molecular Weight:
447.55
MDL Number:
MOL File:
1971937-18-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Properties

Boiling point 664.7±65.0 °C(Predicted)
Density 1.359±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 4.98±0.10(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0371584 ARN19702 99.80% 1971937-18-4 5mg $162 2026-06-04 Buy
ChemScene CS-0371584 ARN19702 99.80% 1971937-18-4 10mg $260 2026-06-04 Buy
ChemScene CS-0371584 ARN19702 99.80% 1971937-18-4 25mg $509 2026-06-04 Buy
ChemScene CS-0371584 ARN19702 99.80% 1971937-18-4 50mg $812 2026-06-04 Buy
ChemScene CS-0371584 ARN19702 99.80% 1971937-18-4 100mg $1278 2026-06-04 Buy
Product number Packaging Price Buy
CS-0371584 5mg $162 Buy
CS-0371584 10mg $260 Buy
CS-0371584 25mg $509 Buy
CS-0371584 50mg $812 Buy
CS-0371584 100mg $1278 Buy

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Chemical Properties, Uses, Production

Biological Activity

ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects[1][2]. ARN19702 (3-10 mg/kg; po; daily; for 7 consecutive days) reduces nociception associated with Paclitaxel-induced neuropathy without development of subacute antinociceptive tolerance in male rats[1]. In male mice, ARN19702 (0.1-30 mg/kg; po) attenuates in a dose-dependent manner the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation[1].. ARN19702 (3-10 mg/kg; po) produces remarkable protective effects against multiple sclerosis in mice[2].Pharmacokinetic properties of ARN19702 in mice 3 mg/kg,i.v 3 mg/kg, p.o. Cmax (ng/mL)1660±166613±68 Tmax (min)(5.0)30 CL (mL/min/Kg)33.2±1.649±8 t1/2 (min)73.9±3.7104±16 AUCplasma (h×ng/mL)1366.8±68.3988±157 AUCbrain (h×ng/mL)404.3±109.1181±28 F (%)-72±11

References

[1]. Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76. [2]. Marco Migliore Dr, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197.

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- Suppliers

Global Suppliers ( 21)
Supplier Tel Email Country ProdList Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9711 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 18171815831 1341138380@qq.com China 4573 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Supplier Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Xianning Shen Lan Biomedical Research and Development Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58

View Latest Price from Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ARN19702 pictures 2026-07-14 ARN19702
1971937-18-4
 $51.00-197.00 99.86% 10g TargetMol Chemicals Inc.
  • ARN19702 pictures
  • ARN19702
    1971937-18-4
  • $51.00-197.00
  • 99.86%
  • TargetMol Chemicals Inc.

1971937-18-4 (Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]-) Related Search:

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Methanone, [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-2-benzothiazolyl)-2-methyl-1-piperazinyl]- ARN19702 ARN19702,ARN-19702 (S)-(2-(Ethylsulfonyl)phenyl)(4-(6-fluorobenzo[d]thiazol-2-yl)-2-methylpiperazin-1-yl)methanone ARN19702, 10 mM in DMSO 2-[(3S)-4-{[2-(ethanesulfonyl)phenyl]carbonyl}-3-methylpiperazin-1-yl]-6-fluoro-1,3-benzothiazole - [AC78069] 1971937-18-4