Quinapril | 85441-61-8

Quinapril Properties

Melting point	120-130°C
Boiling point	662.0±55.0 °C(Predicted)
Density	1.217±0.06 g/cm3(Predicted)
pka	3.39±0.20(Predicted)
BCS Class	1
CAS DataBase Reference	85441-61-8(CAS DataBase Reference)
FDA UNII	RJ84Y44811
ATC code	C09AA06

Pharmacokinetic data

Protein binding	97%
Excreted unchanged in urine	30%
Volume of distribution	1.5(L/kg)
Biological half-life	1 / 12-14

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25

Quinapril price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA01SSVP	Quinapril	85441-61-8	10mg	$882	2026-05-31	Buy
AHH	API-1582	Quinapril 97%		1g	$710	2026-05-26	Buy
AvaChem	1632B	Quinapril	85441-61-8	100mg	$35	2026-05-22	Buy
AvaChem	1632B	Quinapril	85441-61-8	250mg	$55	2026-05-22	Buy
AvaChem	1632B	Quinapril	85441-61-8	1g	$105	2026-05-22	Buy

Product number	Packaging	Price	Buy
AA01SSVP	10mg	$882	Buy
API-1582	1g	$710	Buy
1632B	100mg	$35	Buy
1632B	250mg	$55	Buy
1632B	1g	$105	Buy

Quinapril Chemical Properties,Uses,Production

Description

Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the treatment of essential hypertension. The main claimed advantage of quinapril compared with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure.

Originator

Warner-Lambert (USA)

Uses

Antihypertensive; enzyme inhibitor (angiotensin-converting).

Definition

ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.

brand name

Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy) ;Accupro.

Clinical Use

Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion (possibility of enhanced lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Quniapril is a prodrug which is metabolised in the liver to its active form, quinaprilat, and to minor inactive metabolites.
Quinaprilat is eliminated primarily by renal excretion.

Quinapril Preparation Products And Raw materials

Raw materials

Benzyl ester Trifluoroacetic acid Acetic acid Quinapril hydrochloride Quinazoline

Preparation Products

Quinapril Suppliers

Global( 94)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810 18652991625	sales@sunlidabio.com	China	3223	55
Shanghai Meishui Chemical Technology Co., Ltd	021-60549325 18616193163		China	4518	56
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Wuhan Magic Biological Technology Co., Ltd.	18872289958、027-52304252、3400508168	3400508168@qq.com	China	1901	55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.	027-51831887 15337167856	hubeixinyuanshun@163.com	China	10272	58
Chengdu Saint - Kay Biotechnology Co., Ltd.	028-85157043 15882256948	676046971@qq.com	China	4183	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
LGM Pharma	70
Syntechem Co.,Ltd	57
Beijing HuaMeiHuLiBiological Chemical	58
Nanjing Sunlida Biological Technology Co., Ltd.	55
Shanghai Meishui Chemical Technology Co., Ltd	56
Amadis Chemical Company Limited	58
Wuhan Magic Biological Technology Co., Ltd.	55
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.	58
Chengdu Saint - Kay Biotechnology Co., Ltd.	58

View Lastest Price from Quinapril manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	Quinapril 85441-61-8	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2020-05-10	Quinapril 85441-61-8		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	Quinapril 85441-61-8	$1.00	1kg	95%-99%	10kg	Career Henan Chemical Co

Quinapril
85441-61-8
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Quinapril
85441-61-8
99.0%
Shaanxi Dideu Medichem Co. Ltd

Quinapril
85441-61-8
$1.00
95%-99%
Career Henan Chemical Co

85441-61-8(Quinapril)Related Search:

Isoquinoline 5,6,7,8-Tetrahydroisoquinoline Phenyl valerate Propyl butyrate Propyl gallate

Phenylhydrazine Quinapril hydrochloride Isoquinoline-1-carboxylic acid N-[S-(2-Pyridylthio)cysteaminyl]ethylenediamine-N,N,N',N'-tetraacetic acid, monoamide Quinapril benzyl ester maleate

Carbonyl iron powder Quinapril related compound A ethyl[3s-[2(R*),3a,11a beta]]-1,3,4,6,11,11a-hexahydro-3-methyl-1,4-dioxo-alpha-(2-phenylethyl)-2H-pyrazino[1,2-b]isoquinoline-2-acetate USP QUINAPRILAT Quinapril

1of3

QUINAPRIL HCL PD-109452-2 CI-906 (3S)-2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid (S)-2-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ACCUPRIN ACCUPRO 2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (3s-(2(r*(r*)),3r*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride (3S)-2-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE Asig S-1,2,3,4CTetrahydro-3-IsoquinolinecarboxylicAcid Quniapril 3-Isoquinolinecarboxylic acid, 2-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyl-1,2,3,4-tetrahydro-, (3S)- 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)- (9CI) 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]- Ectren Koretic [3S-[2[R^<*>^ (R^<*>^)]，3R^<*>^]]-2-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1，2，3，4-tetrahydro-3-isoquinolinecarboxylic acid Acequin：Acuitel Korec：Quinazil (3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid (3S)-2-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid Quinapril (3S)-2-[(2S)-2-[[(1S)-1-carbethoxy-3-phenyl-propyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenyl-butan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid JSDRRTOADPPCHY-HSQYWUDLSA-N (3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Quinapril USP/EP/BP ACCUPRIL 85441-61-8 84551-61-8 C25H30N2O5