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ChemicalBook >> CAS DataBase List >>[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1)

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1)

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) Structure
[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) structure
CAS No.
2436747-41-8
Chemical Name:
[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1)
Synonyms
BB-C-Amidine(hydrochloride);[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1)
CBNumber:
CB110493002
Molecular Formula:
C26H27Cl2N5O
Molecular Weight:
496.44
MDL Number:
MOL File:
2436747-41-8.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:33
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[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) Properties

form Solid
color White to off-white

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0094488 BB-Cl-Amidine hydrochloride 99.47% 2436747-41-8 5mg $103 2026-06-04 Buy
ChemScene CS-0094488 BB-Cl-Amidine hydrochloride 99.47% 2436747-41-8 10mg $184 2026-06-04 Buy
ChemScene CS-0094488 BB-Cl-Amidine hydrochloride 99.47% 2436747-41-8 25mg $390 2026-06-04 Buy
ChemScene CS-0094488 BB-Cl-Amidine hydrochloride 99.47% 2436747-41-8 50mg $628 2026-06-04 Buy
ChemScene CS-0094488 BB-Cl-Amidine hydrochloride 99.47% 2436747-41-8 100mg $997 2026-06-04 Buy
Product number Packaging Price Buy
CS-0094488 5mg $103 Buy
CS-0094488 10mg $184 Buy
CS-0094488 25mg $390 Buy
CS-0094488 50mg $628 Buy
CS-0094488 100mg $997 Buy

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) Chemical Properties, Uses, Production

Uses

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor[1].

in vivo

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].

Animal Model:MRL/lpr mice[1].
Dosage:1 mg/kg.
Administration:Subcutaneous injection daily from 8 to 14 weeks of age.
Result:Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.

References

[1] Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206. DOI:10.1136/annrheumdis-2014-205365

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) Suppliers

Global Suppliers ( 8)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai meikai technology co., ltd 021-68689288 15300790979 info@mkbio.com.cn China 9988 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Shanghai meikai technology co., ltd 58
Aladdin Scientific 58

2436747-41-8 ([1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1)) Related Search:

N-[1-(1H-1,3-Benzimidazol-2-yl)-3-methylbutyl]benzenecarboxamide BB-Cl-Amidine hydrochloride BB-F-Yne [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) NA
Photoswitchable PAD Inhibitor (technical grade)

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[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-, hydrochloride (1:1) BB-C-Amidine(hydrochloride) 2436747-41-8