Sulfamethoxypyridazine
- CAS No.
- 80-35-3
- Chemical Name:
- Sulfamethoxypyridazine
- Synonyms
- Sulphamethoxypyridazine;Sulfamethoxypyridazine-d3;SMPZ;Paramid;Sulfametoxipiridazine;6-Sulfanilamido-3-methoxypyridazine;N1-(6-Methoxy-3-pyridazinyl)sulfanilamide;Durox;Kinex;Kynex
- CBNumber:
- CB1107025
- Molecular Formula:
- C11H12N4O3S
- Molecular Weight:
- 280.3
- MDL Number:
- MFCD00057372
- MOL File:
- 80-35-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Sulfamethoxypyridazine European Pharmacopoeia (EP) Reference Standard | S2150000 | 50 mg | $164 |
| Sulfamethoxypyridazine VETRANAL?, analytical standard | 46858 | 250mg | $74.8 |
| Sulfamethoxypyridazine >98.0%(HPLC)(T) | S0591 | 5g | $30 |
| Sulfamethoxypyridazine >98.0%(HPLC)(T) | S0591 | 25g | $81 |
| Sulfamethoxypyridazine ≥95% | 21875 | 5g | $32 |
| More product size | |||
| Melting point | 182-183° |
|---|---|
| Boiling point | 564.9±60.0 °C(Predicted) |
| Density | 1.3936 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 6.7(at 25℃) |
| form | Crystalline Powder |
| color | White to yellow |
| Water Solubility | 579.5mg/L(25 ºC) |
| Merck | 14,8919 |
| BRN | 277076 |
| Major Application |
forensics and toxicology pharmaceutical (small molecule) |
| InChI | InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) |
| InChIKey | VLYWMPOKSSWJAL-UHFFFAOYSA-N |
| SMILES | C1(S(NC2=NN=C(OC)C=C2)(=O)=O)=CC=C(N)C=C1 |
| CAS DataBase Reference | 80-35-3(CAS DataBase Reference) |
| FDA UNII | T034E4NS2Z |
| ATC code | J01ED05 |
| NIST Chemistry Reference | Pyridazine, sulfamethoxy-(80-35-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H334 | |||||||||
| Precautionary statements | P261-P272-P280-P284-P302+P352-P333+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WP0400000 | |||||||||
| F | 10 | |||||||||
| HS Code | 29350090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Resp. Sens. 1 Skin Sens. 1 |
|||||||||
| Toxicity | LD50 orally in mice: 1750 mg/kg, (Seki) | |||||||||
| NFPA 704 |
|
Sulfamethoxypyridazine price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S2150000 | Sulfamethoxypyridazine European Pharmacopoeia (EP) Reference Standard | 80-35-3 | 50 mg | $164 | 2026-03-19 | Buy |
| Sigma-Aldrich | 46858 | Sulfamethoxypyridazine VETRANAL?, analytical standard | 80-35-3 | 250mg | $74.8 | 2026-03-19 | Buy |
| TCI Chemical | S0591 | Sulfamethoxypyridazine >98.0%(HPLC)(T) | 80-35-3 | 5g | $30 | 2026-03-19 | Buy |
| TCI Chemical | S0591 | Sulfamethoxypyridazine >98.0%(HPLC)(T) | 80-35-3 | 25g | $81 | 2026-03-19 | Buy |
| Cayman Chemical | 21875 | Sulfamethoxypyridazine ≥95% | 80-35-3 | 5g | $32 | 2024-03-01 | Buy |
Sulfamethoxypyridazine Chemical Properties,Uses,Production
Chemical Properties
White or slightly yellow crystalline powder; odorless, bitter taste; discolored when exposed to light. The product is slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; easily soluble in dilute hydrochloric acid or alkali hydroxide solution.
Uses
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic with anti-inflammatory and antibacterial effects, mainly used for streptococcus, staphylococcus, Escherichia coli and other infections, especially for urinary tract infections.
Application
Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method.
Indications
This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.
Definition
ChEBI: Sulfamethoxypyridazine is a sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antiinfective agent, an EC 2.5.1.15 (dihydropteroate synthase) inhibitor and a drug allergen. It is a member of pyridazines, a sulfonamide and a sulfonamide antibiotic. It derives from a sulfanilamide.
brand name
Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44.
World Health Organization (WHO)
Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial.
General Description
Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis.
Pharmaceutical Applications
3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim.
Synthesis
Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.
Sulfamethoxypyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2542 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from Sulfamethoxypyridazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Sulfamethoxypyridazine
80-35-3
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-25 | Sulfamethoxypyridazine
80-35-3
|
US $1.00 / kg | 1kg | 99% | 10 | Zhejiang J&C Biological Technology Co.,Limited | |
 |
2025-11-18 | Sulfamethoxypyridazine USP/EP/BP
80-35-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Sulfamethoxypyridazine
80-35-3
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Sulfamethoxypyridazine
80-35-3
- US $1.00 / kg
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
-
- Sulfamethoxypyridazine USP/EP/BP
80-35-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
