2,5,6-Trifluoronicotinic aicid nitrile
- CAS No.
- 870065-73-9
- Chemical Name:
- 2,5,6-Trifluoronicotinic aicid nitrile
- Synonyms
- 3-Cyano-2,5,6-trifluoropyridine;2,5,6-trifluoro-3-cyanopyridine;3-Cyano-2,5,6-trifluoropyridine 98%;2,5,6-trifluoropyridin-3-carbonitrile;2,5,6-Trifluoro-3-pyridinecarbonitrile;2,5,6-Trifluoropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 2,5,6-trifluoro-;2,5,6-Trifluoronicotinic aicid nitrile ISO 9001：2015 REACH
- CBNumber:
- CB11116521
- Molecular Formula:
- C6HF3N2
- Molecular Weight:
- 158.08
- MDL Number:
- MFCD04973023
- MOL File:
- 870065-73-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,5,6-Trifluoro-3-pyridinecarbonitrile | 290323 | 50mg | $419 |
| 2,5,6-Trifluoro-3-pyridinecarbonitrile | 290323 | 100mg | $629 |
| 2,5,6-Trifluoro-3-pyridinecarbonitrile | 290323 | 250mg | $952 |
| 2,5,6-Trifluoro-3-pyridinecarbonitrile | 290323 | 500mg | $1480 |
| 2,5,6-Trifluoro-3-pyridinecarbonitrile | 290323 | 1g | $2387 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
2,5,6-Trifluoronicotinic aicid nitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 290323 | 2,5,6-Trifluoro-3-pyridinecarbonitrile | 870065-73-9 | 50mg | $419 | 2026-06-03 | Buy |
| Usbiological | 290323 | 2,5,6-Trifluoro-3-pyridinecarbonitrile | 870065-73-9 | 100mg | $629 | 2026-06-03 | Buy |
| Usbiological | 290323 | 2,5,6-Trifluoro-3-pyridinecarbonitrile | 870065-73-9 | 250mg | $952 | 2026-06-03 | Buy |
| Usbiological | 290323 | 2,5,6-Trifluoro-3-pyridinecarbonitrile | 870065-73-9 | 500mg | $1480 | 2026-06-03 | Buy |
| Usbiological | 290323 | 2,5,6-Trifluoro-3-pyridinecarbonitrile | 870065-73-9 | 1g | $2387 | 2026-06-03 | Buy |
2,5,6-Trifluoronicotinic aicid nitrile Chemical Properties,Uses,Production
Uses
2,5,6-Trifluoronicotinic aicid nitrile is a pyridine derivative used in the preparation of JAK2 kinase inhibtors.
Synthesis
82671-02-1
870065-73-9
The general procedure for the synthesis of 3-cyano-2,5,6-trifluoropyridine from 3-cyano-2,6-dichloro-5-fluoropyridine was as follows: 2,6-dichloro-5-fluoronicotinonitrile (25.67 g, 134 mmol) was mixed with spray dried potassium fluoride (23.6 g, 406 mmol) (Aldrich) by freshly milling the mixture in air to remove agglomerates and then mixing with thorough shaking. Ensure that the two are completely mixed before adding dry dimethyl sulfoxide (30 mL). The mixture was effectively stirred at room temperature under argon protection for 1-2 min, followed by transfer to a 100°C oil bath for 5 min. The temperature was then raised to 130 °C within 10 min and stirring was continued at this temperature for 40 min. The reaction process was monitored by NMR spectroscopy, which showed a conversion of 86% after 10 minutes of reaction at 130 °C and over 95% after 40 minutes. Upon completion of the reaction, the viscous purple mixture was cooled to room temperature, shaken with dichloromethane (30 mL) in an ice bath, and subsequently upsampled directly onto a fast silica gel column (silica gel 1.0 kg; column size 120 mm × 0.6) that was pre-equilibrated with dichloromethane. Elution with dichloromethane (140 mL of fractions were collected; combined fractions 10-19) afforded 20.65 g of a clarified light amber oily product.NMR analysis showed the product, 3-cyano-2,5,6-trifluoropyridine, to be in a molar ratio of 1:0.58 to dimethylsulfoxide (16.0 g of 3-cyano-2,5,6-trifluoropyridine; 76% yield).1H-NMR (300 MHz, CDCl3) was used for the analysis. MHz, CDCl3) δ 7.99 (m, 1H).LC/MS (ESI): calculated mass 158.0, measured value 159.5 (MH)+.
References
[1] Patent: US2006/241148, 2006, A1. Location in patent: Page/Page column 12
2,5,6-Trifluoronicotinic aicid nitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9631 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14301 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23504 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
View Lastest Price from 2,5,6-Trifluoronicotinic aicid nitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2,5,6-Trifluoronicotinic aicid nitrile
870065-73-9
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-24 | 2,5,6-Trifluoronicotinic aicid nitrile
870065-73-9
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 2,5,6-Trifluoronicotinic aicid nitrile
870065-73-9
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,5,6-Trifluoronicotinic aicid nitrile
870065-73-9
- $1.00
- 99%
- Career Henan Chemical Co
