(R)-(+)-2-Benzyloxypropionic acid
- CAS No.
- 100836-85-9
- Chemical Name:
- (R)-(+)-2-Benzyloxypropionic acid
- Synonyms
- O-BENZYL-D-LACTIC ACID;(R)-(+)-O-Benzyllactic acid;(R)-2-(Benzyloxy)propanoic acid;(2R)-2-(benzyloxy)propanoic acid;(2R)-2-(Benzyloxy)propionic acid;(R)-(+)-2-Benzyloxypropionic acid;(R)-2-(Benzyloxy)propanoic acid ee;(2R)-2-phenylmethoxypropanoic acid;Propanoic acid, 2-(phenylMethoxy)-, (2R)-;(R)-(+)-2-(Benzyloxy)propionic acid[>=97.0% (HPLC)]
- CBNumber:
- CB1111778
- Molecular Formula:
- C10H12O3
- Molecular Weight:
- 180.2
- MDL Number:
- MFCD06799065
- MOL File:
- 100836-85-9.mol
- MSDS File:
- SDS
| Melting point | 52-55 °C |
|---|---|
| Boiling point | 328.2±17.0 °C(Predicted) |
| Density | 1.150 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.57±0.10(Predicted) |
| Appearance | Off-white to yellow <43°C Solid,>43°C Liquid |
| Water Solubility | Insoluble in water. |
| BRN | 4675524 |
| InChI | InChI=1S/C10H12O3/c1-8(10(11)12)13-7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,11,12)/t8-/m1/s1 |
| InChIKey | XWAVPOFYNPXXEL-MRVPVSSYSA-N |
| SMILES | C(O)(=O)[C@H](OCC1=CC=CC=C1)C |
| CAS DataBase Reference | 100836-85-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-43 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(R)-(+)-2-Benzyloxypropionic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AEA83685 | (R)-2-(Benzyloxy)propanoic acid ee | 100836-85-9 | 25g | $312.5 | 2026-06-04 | Buy |
| Activate Scientific | AS116929 | (R)-2-(Benzyloxy)propanoic acid 97%EE | 100836-85-9 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS116929 | (R)-2-(Benzyloxy)propanoic acid 97%EE | 100836-85-9 | 5g | $60 | 2026-06-04 | Buy |
| Activate Scientific | AS116929 | (R)-2-(Benzyloxy)propanoic acid 97%EE | 100836-85-9 | 25g | $112 | 2026-06-04 | Buy |
| Synthonix | B67100 | (R)-(+)-2-Benzyloxypropionic acid >98% | 100836-85-9 | 10g | $50 | 2026-05-06 | Buy |
(R)-(+)-2-Benzyloxypropionic acid Chemical Properties,Uses,Production
Uses
(R)-(+)-2-Benzyloxypropionic acid is used as a pharmaceutical intermediate.
Synthesis
115458-99-6
100836-85-9
The general procedure for the synthesis of (R)-2-(benzyloxy)propionic acid from methyl (R)-2-(benzyloxy)propionate was as follows: potassium hydroxide (KOH, 9.2 g, 163.96 mmol, 3.00 eq.) was added to methyl (2R)-2-(benzyloxy)propionate (11 g, 56.63 mmol, 1.00 eq.) in a methanol/water (90 mL/10 mL) solution. The reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the reaction mixture was concentrated and subsequently diluted with water. The resulting aqueous solution was washed with ethyl acetate and the pH of the aqueous layer was adjusted with aqueous hydrochloric acid to 5. The acidified aqueous layer was extracted with ethyl acetate, the organic layers were combined and washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuum to give 9.6 g (94% yield) of (2R)-2-(benzyloxy)propionic acid as a colorless oil.LC-MS detection showed [M + H]+ = 179.
References
[1] Patent: WO2015/138934, 2015, A1. Location in patent: Paragraph 00174
[2] Tetrahedron Letters, 1998, vol. 39, # 8, p. 779 - 782
[3] Chemistry - A European Journal, 2015, vol. 21, # 26, p. 9370 - 9379
[4] Angewandte Chemie - International Edition, 2015, vol. 54, # 16, p. 4919 - 4922
[5] Angew. Chem., 2015, vol. 127, # 16, p. 5001 - 5004,4
(R)-(+)-2-Benzyloxypropionic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
(R)-(+)-2-Benzyloxypropionic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| AllyChem Co., Ltd. | 0411-62313318 13889470786 | info@allychem.com | China | 1021 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chongqing Xingcan Pharmaceutical Technology Co., Ltd. | 13594048950 19923294409 | xingcanyaoye@sina.com | China | 1591 | 58 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Lastest Price from (R)-(+)-2-Benzyloxypropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | (R)-(+)-2-BENZYLOXYPROPIONIC ACID
100836-85-9
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2020-01-13 | (R)-(+)-2-BENZYLOXYPROPIONIC ACID
100836-85-9
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID
100836-85-9
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- (R)-(+)-2-BENZYLOXYPROPIONIC ACID
100836-85-9
- $1.00
- 99%
- Career Henan Chemical Co
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