BOC-D-NVA-OH
- CAS No.
- 57521-85-4
- Chemical Name:
- BOC-D-NVA-OH
- Synonyms
- N-Boc-D-norvaline dicyclohexylammonium salt;BOC-D-NORVALINE;Boc-D-Norvaline-OH;Boc-D-Nva;NSC 343953;BOC-D-NVAL;BOC-D-NVA-OH;Boc-D-NVal-OH;Cbz-D-Norvaline;BOC-D-APE(2)-OH
- CBNumber:
- CB1112861
- Molecular Formula:
- C10H19NO4
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD00155638
- MOL File:
- 57521-85-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Boc-D-Nva-OH ≥98.0% (TLC) | 12688 | 5G | $650 |
| Boc-D-norvaline (syrup) | 264825 | 2g | $333 |
| Boc-D-norvaline (syrup) | 264825 | 5g | $496 |
| Boc-D-norvaline (syrup) | 264825 | 10g | $674 |
| Boc-D-norvaline (syrup) | 264825 | 25g | $1110 |
| More product size | |||
| Boiling point | 348.3±25.0 °C(Predicted) |
|---|---|
| Density | 1.081±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Powder |
| pka | 4.02±0.20(Predicted) |
| color | White |
| BRN | 5260625 |
| Major Application | peptide synthesis |
| InChI | 1S/C10H19NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h7H,5-6H2,1-4H3,(H,11,14)(H,12,13)/t7-/m1/s1 |
| InChIKey | INWOAUUPYIXDHN-SSDOTTSWSA-N |
| SMILES | CCC[C@@H](NC(=O)OC(C)(C)C)C(O)=O |
| CAS DataBase Reference | 57521-85-4(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29241990 |
| Storage Class | 12 - Non Combustible Liquids |
BOC-D-NVA-OH price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 12688 | Boc-D-Nva-OH ≥98.0% (TLC) | 57521-85-4 | 5G | $650 | 2022-05-15 | Buy |
| Usbiological | 264825 | Boc-D-norvaline (syrup) | 57521-85-4 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 264825 | Boc-D-norvaline (syrup) | 57521-85-4 | 5g | $496 | 2026-06-03 | Buy |
| Usbiological | 264825 | Boc-D-norvaline (syrup) | 57521-85-4 | 10g | $674 | 2026-06-03 | Buy |
| Usbiological | 264825 | Boc-D-norvaline (syrup) | 57521-85-4 | 25g | $1110 | 2026-06-03 | Buy |
BOC-D-NVA-OH Chemical Properties,Uses,Production
Chemical Properties
Clear colorless viscid liquid
Uses
BOC-D-NVA-OH is a chemical reagent used in the preparation of benzothiophene inhibitors of MK2. Also has been used to synthesize pyrrolidine diketopiperazines to inhibit melanoma
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
2013-12-9
24424-99-5
57521-85-4
General procedure for the synthesis of (R)-2-((tert-butylcarbonyl)amino)pentanoic acid from D-norvaline and di-tert-butyl dicarbonate: (R)-2-aminopentanoic acid (2.343 g) and Na2CO3 (2.120 g) were dissolved in water (60.00 mL) to form a mixture. A solution of THF (20 mL) in Boc2O (4.88 mL) was added slowly and dropwise to the mixture at room temperature. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was washed with ether (2 × 20 mL), followed by adjusting the pH of the aqueous phase with K2SO4 solution to 3. The aqueous phase was extracted with EtOAc (2 × 30 mL), the organic phases were combined, and the solvents were evaporated after drying to give (R)-2-((tert-butylcarbonyl)amino)pentanoic acid (4 g) as a viscous oil product. Mass spectrometry (ESI) analysis showed that the theoretical molecular weight of C10H19NO4 was 217; the measured value was 216 [M-H].
References
[1] Patent: US5206235, 1993, A
[2] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 70
BOC-D-NVA-OH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-15680023009 | ni@enlaibio.com | China | 1103 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
View Lastest Price from BOC-D-NVA-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-18 | Boc-D-NVal-OH
57521-85-4
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2021-08-12 | BOC-D-NVA-OH
57521-85-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-15 | BOC-D-NVA-OH
57521-85-4
|
$1.00 | 100g | >98% | Career Henan Chemical Co |
-
- Boc-D-NVal-OH
57521-85-4
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BOC-D-NVA-OH
57521-85-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- BOC-D-NVA-OH
57521-85-4
- $1.00
- >98%
- Career Henan Chemical Co
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