(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
- CAS No.
- 140148-70-5
- Chemical Name:
- (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
- Synonyms
- (S)-1-N-BOC-BETA-PROLINE;N-Boc-L-beta-p;BOC-L-B-PROLINE;(3S)-Boc-β-Pro-OH;(3S)-BOC-BETA-PRO-OH;N-Boc-L-beta-proline;1-N-Boc-delta-Proline;N-Boc-L-^b-proline,95%;N-Boc-L-^b-proline, 95%;(3S)-Boc-β-Pro-OH
- CBNumber:
- CB4225931
- Molecular Formula:
- C10H17NO4
- Molecular Weight:
- 215.25
- MDL Number:
- MFCD03094728
- MOL File:
- 140148-70-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 140-145°C |
|---|---|
| Boiling point | 337.2±35.0 °C(Predicted) |
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.47±0.20(Predicted) |
| form | solid |
| Appearance | White to off-white Solid |
| optical activity | [α]/D +15.0°, c = 0.5% in chloroform |
| Water Solubility | Soluble in water (slightly). |
| InChI | InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1 |
| InChIKey | HRMRQBJUFWFQLX-ZETCQYMHSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC[C@H](C(O)=O)C1 |
| CAS DataBase Reference | 140148-70-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H400 | |||||||||
| Precautionary statements | P273-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 41-50 | |||||||||
| Safety Statements | 26-39-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid price More Price(86)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS005246 | (3S)-Boc-β-Pro-OH Aldrich | 140148-70-5 | 100mg | $77.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 735507 | (S)-1-Boc-3-pyrrolidinecarboxylic acid 97% | 140148-70-5 | 500mg | $152 | 2026-04-30 | Buy |
| Usbiological | 266640 | Boc-(3S)-1-pyrrolidine-3-carboxylic acid | 140148-70-5 | 100mg | $319 | 2026-06-03 | Buy |
| Usbiological | 266640 | Boc-(3S)-1-pyrrolidine-3-carboxylic acid | 140148-70-5 | 250mg | $432 | 2026-06-03 | Buy |
| Usbiological | 266640 | Boc-(3S)-1-pyrrolidine-3-carboxylic acid | 140148-70-5 | 500mg | $559 | 2026-06-03 | Buy |
(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White to light brown solid
Uses
N-Boc-L-beta-proline is an important raw material and intermediate used in pharmaceuticals, agrochemicals and dyestuff.
Synthesis
122684-33-7
72925-16-7
General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining aqueous solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.
References
[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 19138996873 | 670603485@qq.com | China | 196 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-27 | (S)-1-Boc-pyrrolidine-3-carboxylic acid
140148-70-5
|
1KG | 98.0% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-07-06 | (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
140148-70-5
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- (S)-1-Boc-pyrrolidine-3-carboxylic acid
140148-70-5
- $0.00
- 98.0%
- Honest Joy Holdings Limited
-
- (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
140148-70-5
- $1.00
- 95%-99%
- Career Henan Chemical Co
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