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2-Bromo-5-hydroxybenzaldehyde

2-Bromo-5-hydroxybenzaldehyde Structure
2-Bromo-5-hydroxybenzaldehyde structure
CAS No.
2973-80-0
Chemical Name:
2-Bromo-5-hydroxybenzaldehyde
Synonyms
AKOS B020430;Crisaborole-029;ART-CHEM-BB B020430;4-BROMO-3-FORMYLPHENOL;Crisaborole Impurity 32;2-bromo-5-hydroxybenzadehyde;-BROMO-5-HYDROXYBENZALDEHYDE;2-Bromo-5-hydroxybenzaldehyde;Crisaborole Related Compound 2;Benzaldehyde, 2-bromo-5-hydroxy-
CBNumber:
CB1114360
Molecular Formula:
C7H5BrO2
Molecular Weight:
201.02
MDL Number:
MFCD03033065
MOL File:
2973-80-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:35
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2-Bromo-5-hydroxybenzaldehyde Properties

Melting point 130-135 °C
Boiling point 286.7±20.0 °C(Predicted)
Density 1.737±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in chloroform, dichloromethane and ethyl acetate.
form Solid
pka 8.67±0.18(Predicted)
color White to Gray to Brown
InChI InChI=1S/C7H5BrO2/c8-7-2-1-6(10)3-5(7)4-9/h1-4,10H
InChIKey SCRQAWQJSSKCFN-UHFFFAOYSA-N
SMILES C(=O)C1=CC(O)=CC=C1Br
CAS DataBase Reference 2973-80-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xi,N,Xn
Risk Statements  36/37/38-50-22
Safety Statements  26-36/37/39-61
RIDADR  UN 3077
WGK Germany  3
Hazard Note  Irritant
HazardClass  9
PackingGroup  III
HS Code  2909500090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Acute 1
REACH Registrations Active
NFPA 704
1
2 0

2-Bromo-5-hydroxybenzaldehyde price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 710814 2-Bromo-5-hydroxybenzaldehyde 95% 2973-80-0 1g $150 2026-04-30 Buy
TCI Chemical B3997 2-Bromo-5-hydroxybenzaldehyde >97.0%(GC) 2973-80-0 1g $34 2026-04-30 Buy
TCI Chemical B3997 2-Bromo-5-hydroxybenzaldehyde >97.0%(GC) 2973-80-0 5g $129 2026-04-30 Buy
TRC TRC-B684690-5G 2-Bromo-5-hydroxybenzaldehyde 2973-80-0 5g $288 2026-06-03 Buy
TRC TRC-B684690-1G 2-Bromo-5-hydroxybenzaldehyde 2973-80-0 1g $103 2026-06-03 Buy
Product number Packaging Price Buy
710814 1g $150 Buy
B3997 1g $34 Buy
B3997 5g $129 Buy
TRC-B684690-5G 5g $288 Buy
TRC-B684690-1G 1g $103 Buy

2-Bromo-5-hydroxybenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

Pale Grey Solid

Uses

2-Bromo-5-hydroxybenzadehyde is a reactant used in the preparation of many pharmaceutical agents: Bcl-XL, PDE4 inhibitors, inhibitors of prostate cancer cell growth and anti-inflamatory agents.

Uses

2-Bromo-5-hydroxybenzaldehyde is a useful reactant used in the synthesis of PDE4 inhibitors, BCL-XL and cancel cell growth inhibitors. Also an reactant used in the preparation of many pharmaceutical agents.

Synthesis

3-Hydroxybenzaldehyde

100-83-4

2-BROMO-5-HYDROXYBENZALDEHYDE

2973-80-0

General procedure for the synthesis of 2-bromo-5-hydroxybenzaldehyde from m-hydroxybenzaldehyde: 3-hydroxybenzaldehyde (120 g, 0.98 mol) was suspended in 2400 mL of dichloromethane (CH2Cl2) in a 5 L four-necked, round-bottomed flask fitted with an overhead stirrer, a temperature probe, a dosing funnel, and a condenser tube. The mixture was heated to 35-40 °C to completely dissolve the raw material. Bromine (52 mL, 1.0 mol, 1.02 eq.) was added slowly dropwise through the addition funnel, controlling the rate of dropwise acceleration to maintain the reaction temperature between 35-38°C. After dropwise addition, the reaction mixture was stirred at 35 °C overnight. Subsequently, the mixture was slowly cooled to -5-0 °C over a period of 2 h and stirring was continued for 1 h at this temperature. The precipitated solid was collected by filtration through a Brinell funnel and the filter cake was washed with 400 mL of cold 1:1 n-heptane/dichloromethane mixture. The resulting gray solid was dried under vacuum at room temperature (0.2 mmHg). The yield was 124.3 g in 63% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 8, p. 955 - 959
[2] Patent: US2004/19018, 2004, A1. Location in patent: Page/Page column Sheet 2
[3] Journal of the Iranian Chemical Society, 2011, vol. 8, # 2, p. 531 - 536
[4] Tetrahedron Letters, 2009, vol. 50, # 9, p. 1007 - 1009
[5] Synthetic Communications, 2007, vol. 37, # 4, p. 581 - 585

2-Bromo-5-hydroxybenzaldehyde synthesis

7507-86-0
2973-80-0
Synthesis of 2-Bromo-5-hydroxybenzaldehyde from 2-Bromo-5-methoxybenzaldehyde

2-Bromo-5-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

2,4-Dibromo-5-hydroxybenzaldehyde 4-Bromo-3-hydroxybenzaldehyde 3-Hydroxy-4-nitrobenzaldehyde 2-Bromo-5-methoxybenzaldehyde 2-Bromo-3-hydroxybenzaldehyde
Dichloromethane 3-Hydroxybenzaldehyde

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Preparation Products

2-Bromo-5-methoxybenzaldehyde 4-Bromo-3-methylphenol 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile

2-Bromo-5-hydroxybenzaldehyde Suppliers

Global( 441)Suppliers
Supplier Tel Email Country ProdList Advantage
Aktin Chemicals, Inc. 028-85159085 18080455027 info@aktin.com China 2069 58
Sichuan Welltzpharm Inc. 028-028-85182370 info@welltzpharm.com China 40 58
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 19967494293 sales@chemtrue-bio.com China 303 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 145 61
Jinan Chenghui Shuangda biological Co., LTD 053158897070 15550412551 market@jnchsd.com China 224 62
Shan Dong FengJin Pharmaceutical Co.,Ltd. 18364437686 18364437686 15066764791@163.com China 33 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Aktin Chemicals, Inc. 58
Sichuan Welltzpharm Inc. 58
Changzhou Anxuan Chemical, Co., Ltd. 58
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 58
Bayee Biotech (Anqing) Co., Ltd. 61
Jinan Chenghui Shuangda biological Co., LTD 62
Shan Dong FengJin Pharmaceutical Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from 2-Bromo-5-hydroxybenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-BROMO-5-HYDROXYBENZALDEHYDE pictures 2026-09-02 2-BROMO-5-HYDROXYBENZALDEHYDE
2973-80-0
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-BROMO-5-HYDROXYBENZALDEHYDE pictures 2026-06-30 2-BROMO-5-HYDROXYBENZALDEHYDE
2973-80-0
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-BROMO-5-HYDROXYBENZALDEHYDE pictures 2025-04-04 2-BROMO-5-HYDROXYBENZALDEHYDE
2973-80-0
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.

2-Bromo-5-hydroxybenzaldehyde Spectrum

2-BROMO-5-HYDROXYBENZALDEHYDE(2973-80-0)1HNMR2-BROMO-5-HYDROXYBENZALDEHYDE(2973-80-0)FT-IR

2973-80-0(2-Bromo-5-hydroxybenzaldehyde)Related Search:

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2-BroMo-5-hydroxybenzaldehyde, 98%+ Benzaldehyde, 2-bromo-5-hydroxy- 2-Bromo-5-hydroxybenzaldehyde 95% 4-BROMO-3-FORMYLPHENOL AKOS B020430 ART-CHEM-BB B020430 2-Bromo-5-(Hydroxyl)Benzaldehyde -BROMO-5-HYDROXYBENZALDEHYDE 2-bromo-5-hydroxybenzadehyde 2-Bromo-5-hydroxybenzaldehyde > Crisaborole Related Compound 2 Crisaborole Impurity 32 2-BROMO-5-HYDROXYBENZALDEHYDE ISO 9001：2015 REACH Crisaborole-029 2973-80-0 2-Bromo-5hydroxybenzaldehyde 2973-80-0 2-Bromo-5-hydroxybenzaldehyde, CAS 2973-80-0 2-Bromo-5-hydroxybenzaldehyde 2973-80-0 2973-80-8 2873-80-0 C7H5O2Br API intermediates Aryl Halogenated Organohalides