3-Bromo-5-chlorophenol
- CAS No.
- 56962-04-0
- Chemical Name:
- 3-Bromo-5-chlorophenol
- Synonyms
- 3-BroMo-chlorophenol;3-BROMO-5-CHLOROPHENOL;Phenol, 3-bromo-5-chloro-;3-BroMo-5-chlorophenol, 97+%
- CBNumber:
- CB11177445
- Molecular Formula:
- C6H4BrClO
- Molecular Weight:
- 207.45
- MDL Number:
- MFCD07780676
- MOL File:
- 56962-04-0.mol
- MSDS File:
- SDS
| Melting point | 66-70℃ |
|---|---|
| Boiling point | 256°C (rough estimate) |
| Density | 1.6027 (rough estimate) |
| vapor pressure | 0.004-0.084Pa at 20-50℃ |
| refractive index | 1.5730 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 8.04±0.10(Predicted) |
| form | Solid |
| Appearance | White to off-white Solid |
| LogP | 3.2 at 25℃ and pH2 |
| Surface tension | 54.7mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 56962-04-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2908190090 | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
3-Bromo-5-chlorophenol price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB66909 | 3-Bromo-5-chlorophenol | 56962-04-0 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FB66909 | 3-Bromo-5-chlorophenol | 56962-04-0 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FB66909 | 3-Bromo-5-chlorophenol | 56962-04-0 | 10g | $150 | 2026-06-04 | Buy |
| Apolloscientific | OR399004 | 3-Bromo-5-chlorophenol >98% | 56962-04-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR399004 | 3-Bromo-5-chlorophenol >98% | 56962-04-0 | 25g | $71 | 2026-06-04 | Buy |
3-Bromo-5-chlorophenol Chemical Properties, Uses, Production
Uses
3-Chloro-5-bromophenol is an important pharmaceutical intermediate that can be used in the preparation of a variety of pharmaceutical products.
Synthesis
108-37-2
56962-04-0
General procedure for the synthesis of 3-bromo-5-chlorophenol from m-chlorobromobenzene: In an argon-purged flask, (1,5-cyclooctadiene)(methoxy)iridium(I) dimer (84 mg, 0.13 mmol), 4,4'-di-tert-butyl-2,2'-bipyridine (69 mg, 0.26 mmol), and bis(pinacolate)diboron (1.29 g, 5.11 mmol) were added. 5.11 mmol), followed by hexane (26 mL) and 1-bromo-3-chlorobenzene (1 mL, 8.51 mmol) sequentially. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and redissolved in acetone (26 mL) followed by addition of an aqueous (26 mL) solution of Oxone (5.23 g, 8.51 mmol) [Note: exothermic phenomena were observed during the reaction].After 10 min, the reaction mixture was diluted with dichloromethane. The organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane. The organic phases were combined, washed with brine, dried and concentrated in vacuum to give 3-bromo-5-chlorophenol (1.43 g, 81% yield).LCMS (Method 3): retention time 3.74 min, mass-to-charge ratio m/z 205,207 [M-H+].
References
[1] Patent: US2014/364412, 2014, A1. Location in patent: Paragraph 0683; 0684
[2] Patent: WO2014/195402, 2014, A1. Location in patent: Page/Page column 217
[3] Patent: WO2009/115515, 2009, A1. Location in patent: Page/Page column 44-45
[4] Journal of the American Chemical Society, 2003, vol. 125, # 26, p. 7792 - 7793
[5] Synthesis, 2011, # 6, p. 857 - 859
3-Bromo-5-chlorophenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3828 | 58 |
View Latest Price from 3-Bromo-5-chlorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-Bromo-5-chlorophenol
56962-04-0
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 3-Bromo-5-chlorophenol
56962-04-0
- $1.00
- 99%
- Career Henan Chemical Co
