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2'-Deoxy-5-fluorocytidine

2'-Deoxy-5-fluorocytidine Structure
2'-Deoxy-5-fluorocytidine structure
CAS No.
10356-76-0
Chemical Name:
2'-Deoxy-5-fluorocytidine
Synonyms
FCDR;FdCyd;5--F-dC;NSC 48006;Ro 5-1090;5-F-2'-dC;5-Fluoro-2;5-F-2'-deoxycytidine;5-fluorodeoxycytidine;5-fluor-desoxycytidin
CBNumber:
CB1122369
Molecular Formula:
C9H12FN3O4
Molecular Weight:
245.21
MDL Number:
MFCD00077348
MOL File:
10356-76-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:36
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2'-Deoxy-5-fluorocytidine Properties

Melting point 196 °C
Boiling point 465℃
Density 1.82
refractive index 70 ° (C=1, H2O)
Flash point 235℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO: >20mg/mL
form powder
pka 14.03±0.60(Predicted)
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI 1S/C9H12FN3O4/c10-4-2-13(9(16)12-8(4)11)7-1-5(15)6(3-14)17-7/h2,5-7,14-15H,1,3H2,(H2,11,12,16)/t5-,6+,7+/m0/s1
InChIKey IDYKCXHJJGMAEV-RRKCRQDMSA-N
SMILES NC1=NC(=O)N(C=C1F)[C@H]2C[C@H](O)[C@@H](CO)O2
CAS DataBase Reference 10356-76-0(CAS DataBase Reference)
NCI Dictionary of Cancer Terms 5-fluoro-2-deoxycytidine; FdCyd
FDA UNII KUA4693H5W
NCI Drug Dictionary 5-fluoro-2-deoxycytidine
EPA Substance Registry System 5-Fluoro-2'-deoxycytidine (10356-76-0)
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  HA3850000
HS Code  2940.00.6000
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

2'-Deoxy-5-fluorocytidine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F5307 5?Fluoro?2′?deoxycytidine ≥98% (HPLC), powder 10356-76-0 5mg $101 2026-04-30 Buy
Sigma-Aldrich F5307 5?Fluoro?2′?deoxycytidine ≥98% (HPLC), powder 10356-76-0 25mg $392 2026-04-30 Buy
TCI Chemical D3642 2'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T) 10356-76-0 1g $247 2026-04-30 Buy
TCI Chemical D3642 2'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T) 10356-76-0 5g $822 2023-06-20 Buy
Cayman Chemical 37477 2''-Deoxy-5-fluorocytidine ≥98% 10356-76-0 250mg $85 2026-04-30 Buy
Product number Packaging Price Buy
F5307 5mg $101 Buy
F5307 25mg $392 Buy
D3642 1g $247 Buy
D3642 5g $822 Buy
37477 250mg $85 Buy

2'-Deoxy-5-fluorocytidine Chemical Properties, Uses, Production

Description

5-Fluoro-2-Deoxycytidine is an antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.

Uses

5-Fluoro-2''-deoxycytidine is a mechanism-based DNMT inhibitor.

Uses

5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.

General Description

Fine white powder.

Air & Water Reactions

2'-DEOXY-5-FLUOROCYTIDINE is probably light and air sensitive.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 2'-DEOXY-5-FLUOROCYTIDINE emits toxic fumes of fluoride ion and NOx.

Fire Hazard

Flash point data for 2'-DEOXY-5-FLUOROCYTIDINE are not available. 2'-DEOXY-5-FLUOROCYTIDINE is probably combustible.

Pharmacology

5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analog, has a short (10-minute) half-life and is rapidly degraded in vivo by cytidine deaminase. However, coadministration with tetrahydrouridine (THU), an inhibitor of cytidine/deoxycytidine deaminase, has been shown to increase the AUC of the parent compound more than 4-fold. Increased FdCyd exposure allows it to be taken up intracellularly and converted to its triphosphate, which is incorporated into DNA and inhibits the action of the enzyme DNA methyltransferase (DNMT). Inhibition of DNMT, and in turn DNA methylation, can result in the re-expression of tumor suppressor genes.
Primary objective:
-Determine progression-free survival (PFS) and/or the response rate (CR + PR) of FdCyd administered 5 days per week for 2 weeks, in 28-day cycles, by intravenous infusion over 3 hours along with THU in patients with breast cancer, head and neck cancer, non-small cell lung cancer, and urothelial transitional cell carcinoma.
Exploratory objectives:
Evaluate whether treatment with FdCyd and THU alters DNA methylation patterns in tumor biopsy samples before and during treatment by LINE-1 analysis.
Evaluate the safety and tolerability of FdCyd (100 mg/m(2)) + THU (350 mg/m(2)) administered 5 days per week for 2 weeks, in 28-day cycles, by intravenous infusion over 3 hours.
Measure changes in the number of CTCs following treatment with FdCyd plus THU.

Clinical Use

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.

References

[1] JUAN REN . DNA hypermethylation as a chemotherapy target[J]. Cellular signalling, 2011, 23 7: Pages 1082-1093. DOI:10.1016/j.cellsig.2011.02.003
[2] HUMAIRA GOWHER  Albert J. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy.[J]. Cancer Biology & Therapy, 2004, 3 11: 1062-1068. DOI:10.4161/cbt.3.11.1308
[3] QUANYI ZHAO. Inhibition of cancer cell proliferation by 5-fluoro-2’-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway.[J]. SpringerPlus, 2012, 1 1: 65. DOI:10.1186/2193-1801-1-65
[4] YOHICHI KUMAKI. In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections[J]. Antiviral research, 2011, 92 2: Pages 329-340. DOI:10.1016/j.antiviral.2011.09.001

2'-Deoxy-5-fluorocytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Deoxy-5-fluorocytidine Suppliers

Global Suppliers ( 168)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Hongene Biotech Corporation 021-64757213 info@hongene.com China 672 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Hongene Biotech Corporation 61
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Adamas Reagent, Ltd. 59
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57

View Latest Price from 2'-Deoxy-5-fluorocytidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-DEOXY-5-FLUOROCYTIDINE pictures 2026-09-18 2'-DEOXY-5-FLUOROCYTIDINE
10356-76-0
 1Kg 98% 20Ton Xinxiang Aurora Biotechnology Co.,Ltd.
2'-DEOXY-5-FLUOROCYTIDINE pictures 2026-09-18 2'-DEOXY-5-FLUOROCYTIDINE
10356-76-0
 1Kg 98% 20Ton Xinxiang Aurora Biotechnology Co.,Ltd.
2'-DEOXY-5-FLUOROCYTIDINE pictures 2026-09-18 2'-DEOXY-5-FLUOROCYTIDINE
10356-76-0
 1G 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.

2'-Deoxy-5-fluorocytidine Spectrum

2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)MS2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)1HNMR2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)IR12'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)IR2

10356-76-0 (2'-Deoxy-5-fluorocytidine) Related Search:

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2’-deoxy-5-fluoro-cytidin 5-fluor-desoxycytidin 5-fluorodeoxycytidine 5--F-dC 2′-deoxy-5-fluoroCytidine\5-Fluoro-2′-deoxycytidine 4-AMino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one Cytidine,2'-deoxy-5-fluoro- FCDR FdCyd 5-F-2'-deoxycytidine 5-Fluoro-2 NSC 48006 Ro 5-1090 5-F-2'-dC 2'-Deoxy-5-fluorocytidine> -Deoxy-5-fluorocytidine 5-Fluoro-2'-deoxycytidine 2'-Deoxy-5-fluorocytidine 5-Fluoro-2''-deoxycytidine 5-Fluoro-2''-deoxycytidine, 10 mM in DMSO 2'-Deoxy-5-fluorcytidine 2'-Deoxy-5-fluorcytidine 5-Fluoro-2'-deoxycytidine 2'-Deoxy-5-fluorocytidine 10356-76-0 Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents Nucleosides-5-F Nucleosides