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L-3,4-DIFLUOROPHENYLALANINE

L-3,4-DIFLUOROPHENYLALANINE Structure
L-3,4-DIFLUOROPHENYLALANINE structure
CAS No.
31105-90-5
Chemical Name:
L-3,4-DIFLUOROPHENYLALANINE
Synonyms
L-3,4-DIFLUOROPHE;H-PHE(3,4-F 2)-OH;H-PHE(3,4-DIF)-OH;L-Phe(3,4-DiF)-OH;H-D-PHE(M,P-F2)-OH;H-L-Phe(3,4-F2)-OH;RARECHEM BK PT 0121;L-3,4-Difluoro-phe-OH;H-3,4-DIFLUORO-L-PHE-OH;4-Difuoro-L-phenylalanine
CBNumber:
CB1122899
Molecular Formula:
C9H9F2NO2
Molecular Weight:
201.17
MDL Number:
MFCD01075125
MOL File:
31105-90-5.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:46
Product description Number Pack Size Price
3,4-Difluoro-L-phenylalanine D451195 1g $75
3,4-Difluoro-L-phenylalanine D451195 100mg $45
L-3,4-Difluorophenylalanine 273873 500mg $333
3,4-Difluoro-L-phenylalanine PC8363 5g $333
L-3,4-Difluorophenylalanine FD48010 2g $350
More product size
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L-3,4-DIFLUOROPHENYLALANINE Properties

Boiling point 311.9±42.0 °C(Predicted)
Density 1.379±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Sealed in dry,Room Temperature
pka 2.16±0.20(Predicted)
Appearance White to off-white Solid
CAS DataBase Reference 31105-90-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261
Hazard Codes  Xi
HS Code  2922498590
NFPA 704
1
0 0

L-3,4-DIFLUOROPHENYLALANINE price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D451195 3,4-Difluoro-L-phenylalanine 31105-90-5 1g $75 2021-12-16 Buy
TRC D451195 3,4-Difluoro-L-phenylalanine 31105-90-5 100mg $45 2021-12-16 Buy
Usbiological 273873 L-3,4-Difluorophenylalanine 31105-90-5 500mg $333 2021-12-16 Buy
Apolloscientific PC8363 3,4-Difluoro-L-phenylalanine 31105-90-5 5g $333 2021-12-16 Buy
Biosynth Carbosynth FD48010 L-3,4-Difluorophenylalanine 31105-90-5 2g $350 2021-12-16 Buy
Product number Packaging Price Buy
D451195 1g $75 Buy
D451195 100mg $45 Buy
273873 500mg $333 Buy
PC8363 5g $333 Buy
FD48010 2g $350 Buy

L-3,4-DIFLUOROPHENYLALANINE Chemical Properties,Uses,Production

Chemical Properties

Off-white solid powder

Synthesis

trans-3,4-Difluorocinnamic acid

112897-97-9

L-3,4-DIFLUOROPHENYLALANINE

31105-90-5

GENERAL METHODS: Suitable aldehydes 1j, 1n, or 1o (0.5 mmol), malonic acid (1.0 mmol), and piperidine (0.01 mmol) were dissolved in DMSO (500 mL), and the mixture was subsequently heated in a microwave reactor (60°C, 30 min). Upon completion of the reaction, the mixture was cooled to room temperature and ammonia solution (9.5 mL, 13% w/v, ~7 M, adjusted to pH 10.0 by slow addition of dry ice) was added, followed by addition of excess E. coli BL21(DE3) cells (400 mg wet cell paste) to catalyze the production of the target product, 3,4-difluoro-L-phenylalanine. The suspension was stirred at 37°C for several hours and the progress of the reaction was monitored by HPLC. To isolate the product, the reaction mixture was acidified to pH < 2.0 using aqueous sulfuric acid (20% w/v), followed by centrifugation (8000 rpm, 5 min) to remove the cells and the unconverted substrate precipitate. Dowex 50WX8 hydrogen-based resin (5.0 g) was loaded into a disposable plastic column and washed sequentially with deionized water (20 mL) and aqueous sulfuric acid solution (20 mL, 5% w/v). The supernatant after biotransformation was upsampled to the resin column at a flow rate of 1 mL/min. The resin bed was first rinsed with deionized water until the effluent was neutral, and then the product was eluted with aqueous ammonia solution (20 mL, 5% w/v). The product-containing fractions were combined and dried overnight in a centrifugal evaporator to give the corresponding L-phenylalanine derivatives L-3j, L-3n, or L-3o as white solids.4.7.1. (S)-2-Amino-3-(3,4-difluorophenyl)propionic acid (L-3j). Yield: 84 mg (84%), ee value 99% by HPLC.1H NMR (D2O/NaOH, 400 MHz), δ: 7.03-7.18 (m, 2H), 6.90-6.99 (m, 1H), 3.36-3.44 ( m, 1H), 2.81-2.90 (dd, J = 13.6, 6.0 Hz, 1H), 2.70-2.79 (dd, J = 13.6, 7.2 Hz, 1H).13C NMR (D2O/NaOH, 101 MHz), δ: 182.06, 150.94 ( dd, 1JCF = 243 Hz, 2JCF = 12 Hz), 150.09 (dd, 1JCF = 242 Hz, 2JCF = 13 Hz), 135.33 (dd, 3JCF = 5 Hz, 4JCF = 3 Hz), 125.51 (dd, 3JCF = 6 Hz, 4JCF = 3 Hz), 117.83 (d, 2JCF = 17 Hz), 116.97 (dd, 2JCF = 17 Hz), 57.33, 39.94. HRMS (ESI), m/z: calculated value 202.0680 [MH] , measured value 202.0689 [MH]

References

[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262

L-3,4-DIFLUOROPHENYLALANINE Preparation Products And Raw materials

Raw materials

trans-3,4-Difluorocinnamic acid Ammonium hydroxide Carbon dioxide Dimethyl sulfoxide

Preparation Products

L-3,4-DIFLUOROPHENYLALANINE Suppliers

Global( 121)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14343 58
GL Biochem (Shanghai) Ltd. 		+86-021-61263370 +86-18901917034 CHINA 3904 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 19282 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
career henan chemical co 		58
Win-Win chemical CO., Limited 		58
GL Biochem (Shanghai) Ltd. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dideu Industries Group Limited 		58
Nextpeptide Inc 		58
Labnetwork lnc. 		58

View Lastest Price from L-3,4-DIFLUOROPHENYLALANINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-3,4-DIFLUOROPHENYLALANINE pictures 2021-08-12 L-3,4-DIFLUOROPHENYLALANINE
31105-90-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
L-3,4-DIFLUOROPHENYLALANINE pictures 2020-01-01 L-3,4-DIFLUOROPHENYLALANINE
31105-90-5
 US $1.00 / KG 1KG 95-99% 1ton Career Henan Chemical Co

L-3,4-DIFLUOROPHENYLALANINE Spectrum

L-3,4-DIFLUOROPHENYLALANINE(31105-90-5)1HNMR

31105-90-5(L-3,4-DIFLUOROPHENYLALANINE)Related Search:

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RARECHEM BK PT 0121 (S)-2-AMINO-3-(3,4-DIFLUORO-PHENYL)-PROPIONIC ACID H-PHE(3,4-DIF)-OH H-PHE(3,4-F 2)-OH L-3,4-DIFLUOROPHE L-3,4-DIFLUOROPHENYLALANINE H-D-PHE(M,P-F2)-OH H-3,4-DIFLUORO-L-PHE-OH 3,4-DIFLUORO-L-PHENYLALANINE (2S)-2-amino-3-(3,4-difluorophenyl)propanoic acid 3-(3,4-Difluorophenyl)-L-alanine H-L-Phe(3,4-F2)-OH 3,4-Difuoro-L-phenylalanine 4-Difuoro-L-phenylalanine L-3,4-Difluorophenylalanine H-3,4-difluoro-L-Phe-OH L-Phenylalanine,3,4-difluoro- L-3,4-Difluorophenylalanine98+% L-Phe(3,4-DiF)-OH (S)-2-AMino-3-(3,4-difluorophenyl)propanoic acid L-3,4-Difluoro-phe-OH (2S)-2-amino-3-(3,4-difluorophenyl)propanoicaci L-3,4-DIFLUOROPHENYLALANINE USP/EP/BP 31105-90-5 Phenylalanine analogs and other aromatic alpha amino acids Amino Acids