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ChemicalBook >> CAS DataBase List >>L-3,4-Difluorophenylalanine

L-3,4-Difluorophenylalanine

L-3,4-Difluorophenylalanine Structure
L-3,4-Difluorophenylalanine structure
CAS No.
31105-90-5
Chemical Name:
L-3,4-Difluorophenylalanine
Synonyms
3,4-DIFLUORO-L-PHENYLALANINE;L-3,4-DIFLUOROPHE;H-PHE(3,4-F 2)-OH;H-PHE(3,4-DIF)-OH;L-Phe(3,4-DiF)-OH;H-L-Phe(3,4-F2)-OH;H-D-PHE(M,P-F2)-OH;RARECHEM BK PT 0121;L-3,4-Difluoro-phe-OH;H-3,4-DIFLUORO-L-PHE-OH
CBNumber:
CB1122899
Molecular Formula:
C9H9F2NO2
Molecular Weight:
201.17
MDL Number:
MFCD01075125
MOL File:
31105-90-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:36
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L-3,4-Difluorophenylalanine Properties

Boiling point 311.9±42.0 °C(Predicted)
Density 1.379±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Sealed in dry,Room Temperature
pka 2.16±0.20(Predicted)
Appearance White to off-white Solid
CAS DataBase Reference 31105-90-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P261
Hazard Codes  Xi
HS Code  2922498590
NFPA 704
1
0 0

L-3,4-Difluorophenylalanine price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 273873 L-3,4-Difluorophenylalanine Asreported 31105-90-5 500mg $333 2026-06-03 Buy
Usbiological 273873 L-3,4-Difluorophenylalanine Asreported 31105-90-5 1g $489 2026-06-03 Buy
Usbiological 273873 L-3,4-Difluorophenylalanine Asreported 31105-90-5 2g $664 2026-06-03 Buy
Usbiological 273873 L-3,4-Difluorophenylalanine Asreported 31105-90-5 5g $1244 2026-06-03 Buy
Usbiological 273873 L-3,4-Difluorophenylalanine Asreported 31105-90-5 10g $1785 2026-06-03 Buy
Product number Packaging Price Buy
273873 500mg $333 Buy
273873 1g $489 Buy
273873 2g $664 Buy
273873 5g $1244 Buy
273873 10g $1785 Buy

L-3,4-Difluorophenylalanine Chemical Properties,Uses,Production

Chemical Properties

Off-white solid powder

Synthesis

trans-3,4-Difluorocinnamic acid

112897-97-9

L-3,4-DIFLUOROPHENYLALANINE

31105-90-5

GENERAL METHODS: Suitable aldehydes 1j, 1n, or 1o (0.5 mmol), malonic acid (1.0 mmol), and piperidine (0.01 mmol) were dissolved in DMSO (500 mL), and the mixture was subsequently heated in a microwave reactor (60°C, 30 min). Upon completion of the reaction, the mixture was cooled to room temperature and ammonia solution (9.5 mL, 13% w/v, ~7 M, adjusted to pH 10.0 by slow addition of dry ice) was added, followed by addition of excess E. coli BL21(DE3) cells (400 mg wet cell paste) to catalyze the production of the target product, 3,4-difluoro-L-phenylalanine. The suspension was stirred at 37°C for several hours and the progress of the reaction was monitored by HPLC. To isolate the product, the reaction mixture was acidified to pH < 2.0 using aqueous sulfuric acid (20% w/v), followed by centrifugation (8000 rpm, 5 min) to remove the cells and the unconverted substrate precipitate. Dowex 50WX8 hydrogen-based resin (5.0 g) was loaded into a disposable plastic column and washed sequentially with deionized water (20 mL) and aqueous sulfuric acid solution (20 mL, 5% w/v). The supernatant after biotransformation was upsampled to the resin column at a flow rate of 1 mL/min. The resin bed was first rinsed with deionized water until the effluent was neutral, and then the product was eluted with aqueous ammonia solution (20 mL, 5% w/v). The product-containing fractions were combined and dried overnight in a centrifugal evaporator to give the corresponding L-phenylalanine derivatives L-3j, L-3n, or L-3o as white solids.4.7.1. (S)-2-Amino-3-(3,4-difluorophenyl)propionic acid (L-3j). Yield: 84 mg (84%), ee value 99% by HPLC.1H NMR (D2O/NaOH, 400 MHz), δ: 7.03-7.18 (m, 2H), 6.90-6.99 (m, 1H), 3.36-3.44 ( m, 1H), 2.81-2.90 (dd, J = 13.6, 6.0 Hz, 1H), 2.70-2.79 (dd, J = 13.6, 7.2 Hz, 1H).13C NMR (D2O/NaOH, 101 MHz), δ: 182.06, 150.94 ( dd, 1JCF = 243 Hz, 2JCF = 12 Hz), 150.09 (dd, 1JCF = 242 Hz, 2JCF = 13 Hz), 135.33 (dd, 3JCF = 5 Hz, 4JCF = 3 Hz), 125.51 (dd, 3JCF = 6 Hz, 4JCF = 3 Hz), 117.83 (d, 2JCF = 17 Hz), 116.97 (dd, 2JCF = 17 Hz), 57.33, 39.94. HRMS (ESI), m/z: calculated value 202.0680 [MH] , measured value 202.0689 [MH]

References

[1] Tetrahedron, 2016, vol. 72, # 46, p. 7256 - 7262

L-3,4-Difluorophenylalanine Preparation Products And Raw materials

Raw materials

trans-3,4-Difluorocinnamic acid Ammonium hydroxide Carbon dioxide Dimethyl sulfoxide

Preparation Products

L-3,4-Difluorophenylalanine Suppliers

Global( 122)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shenzhen Sungening Bio-Tech Co., Ltd +86-0755-89668383 sales@sungening.com China 1319 65
Supplier Advantage
Shanghai HC Biotech Co., Ltd 55
Alfa Aesar 84
Energy Chemical 61
Capot Chemical Co., Ltd 66
Suzhou haiyu Biochem Industrial Co., LTD 62
Pure Chemistry Scientific Inc. 62
Shanghai Hanhong Scientific Co.,Ltd. 64
ChemPep, Inc. 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shenzhen Sungening Bio-Tech Co., Ltd 65

View Lastest Price from L-3,4-Difluorophenylalanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-3,4-DIFLUOROPHENYLALANINE pictures 2021-08-12 L-3,4-DIFLUOROPHENYLALANINE
31105-90-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
L-3,4-DIFLUOROPHENYLALANINE pictures 2020-01-01 L-3,4-DIFLUOROPHENYLALANINE
31105-90-5
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

L-3,4-Difluorophenylalanine Spectrum

L-3,4-DIFLUOROPHENYLALANINE(31105-90-5)1HNMR

31105-90-5(L-3,4-Difluorophenylalanine)Related Search:

L-2-(5-Bromothienyl)alanine L-2-Bromophenylalanine 3-(2-Naphthyl)-L-alanine 3,3-Diphenyl-L-alanine 3,4-Dichlorophenylalanine
L-4-Thiazolylalanine L-3,5-Difluorophe D-2,4-Difluorophenylalanine L-2,5-Difluorophenylalanine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-3,4-DIFLUOROPHENYLALANINE,FMOC-L-3,4-DIFLUOROPHENYLALANINE,Fluorenylmethoxycarbonyl-L-3,4-difluorophenylalanine
3,4-DIFLUOROPHENYLALANINE,Difluorophenylalanine4,DL-3,4-DIFLUOROPHENYLALANINE 2,3,4-Trifluoro-L-phenylalanine BOC-L-3,4-DIFLUOROPHENYLALANINE,tert-butoxycarbonyl-l-3,4-difluorophenylalanine,Boc-3,4-difluorophenylalanine,N-TERT-BUTOXYCARBONYL-L-3,4-DIFLUOROPHENYLALANINE FMOC-D-3,4-Difluorophe 2,5-Difluoro-DL-phenylalanine
Fmoc-D-3,5-difluorophe Boc-L-3,5-difluorophe L-3,4-Difluorophenylalanine

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RARECHEM BK PT 0121 (S)-2-AMINO-3-(3,4-DIFLUORO-PHENYL)-PROPIONIC ACID H-PHE(3,4-DIF)-OH H-PHE(3,4-F 2)-OH L-3,4-DIFLUOROPHE H-D-PHE(M,P-F2)-OH H-3,4-DIFLUORO-L-PHE-OH (2S)-2-amino-3-(3,4-difluorophenyl)propanoic acid 3-(3,4-Difluorophenyl)-L-alanine H-L-Phe(3,4-F2)-OH 3,4-Difuoro-L-phenylalanine 4-Difuoro-L-phenylalanine L-3,4-Difluorophenylalanine H-3,4-difluoro-L-Phe-OH L-Phenylalanine,3,4-difluoro- L-3,4-Difluorophenylalanine98+% L-Phe(3,4-DiF)-OH (S)-2-AMino-3-(3,4-difluorophenyl)propanoic acid L-3,4-Difluoro-phe-OH (2S)-2-amino-3-(3,4-difluorophenyl)propanoicaci L-3,4-DIFLUOROPHENYLALANINE USP/EP/BP 3,4-DIFLUORO-L-PHENYLALANINE L-3,4-Difluorophenylalanine 31105-90-5 Phenylalanine analogs and other aromatic alpha amino acids Amino Acids